A single amino acid in the second transmembrane domain of GABA ρ subunits is a determinant of the response kinetics of GABA(C) receptors

Journal of Neurobiology

Volumn 40, Issue 1, 1999, Pages 67-76

  Qian, Haohua ^a   Dowling, John E ^b   Ripps, Harris ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

GABA subunits; GABA(C) receptors; Imidazole 4 acetic acid; Response kinetics; Site directed mutagenesis

Indexed keywords

4 IMIDAZOLEACETIC ACID;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL CELL; ARTICLE; DESENSITIZATION; EVOKED RESPONSE; LIGAND BINDING; NEUROTRANSMITTER RELEASE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR DENSITY; RETINA NERVE CELL; SECOND MESSENGER; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELL MEMBRANE; DNA PRIMERS; FEMALE; GAMMA-AMINOBUTYRIC ACID; KINETICS; MACROMOLECULAR SUBSTANCES; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEURONS; OOCYTES; PERCHES; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, GABA; RECOMBINANT FUSION PROTEINS; RETINA; RODS (RETINA); SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS LAEVIS;

EID: 0033050627     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4695(199907)40:1<67::AID-NEU6>3.0.CO;2-4     Document Type: Article

References (35)

1. Amin J, Weiss DS. 1994. Homomeric p1 GABA channels: activation properties and domains. Receptors Channels 2:227-236.
2. Amin J, Weiss DS. 1996. Insights into the activation mechanism of r1 GABA receptors obtained by coexpression of wild type and activation-impaired subunits. Proc R Soc Lond B 263:273-282.
3. Barnard EA. 1992. Receptor classes and the transmittergated ion channels. Trends Biochem Sci 17:368-374.
4. A receptors: classification on the basis of subunit structure and receptor function. Pharmacol Rev 50:291-313.
5. A receptor. Synapse 26:324-327.
6. Buhr A, Sigel E. 1997. A point mutation in the γ2 subunit of γ-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity. Proc Natl Acad Sci USA 94:8824-8829.
7. Chang Y, Weiss DS. 1998. Substitutions of the highly conserved M2 leucine create spontaneously opening p1 gamma-aminobutyric acid receptors. Mol Pharmacol 53: 511-523.
8. C receptors: a novel receptor family with unusual pharmacology. News Physiol Sci 12:136-141.
9. Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR. 1992. Identification of a putative γ-aminobutyric acid (GABA) receptor subunit p2 cDNA and colocalization of the genes encoding p2 (GABRR2) and p1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics 12:801-806.
10. Cutting GR, Lu L, O'Hara BF, Kasch LM, Montrose-Rafizadeh C, Donovan DM, Shimada S, Antonarakis SE, Guggino WB, Uhl GR, Kazazian HH. 1991. Cloning of the γ-aminobutyric acid (GABA) p1 cDNA: a GABA receptor subunit highly expressed in the retina. Proc Natl Acad Sci USA 88:2673-2677.
11. C receptor rho subunits expressed in the human retina? Invest Ophthalmol Vis Sci 39(Suppl):s663.
12. - channels in rat retinal bipolar cells. Nature 361:159-162.
13. Grant GB, Werblin FS. 1994. Low-cost data acquisition and analysis programs for electrophysiology. J Neurosci Methods 55:89-98.
14. C receptors on carp retinal bipolar cells. Neuroreport 8:1331-1335.
15. C receptors. In: Enna SJ, Bowery NG, editors. The GABA receptors. New Jersey: Humana Press p 297-323.
16. Kleingoor C, Wieland HA, Korpi ER, Seeburg PH, Kettenmann H. 1993. Current potentiation by diazepam but not GABA sensitivity is determined by a single histidine residue. Neuroreport 4:187-190.
17. A receptor channels. Annu Rev Neurosci 17:569-602.
18. A-receptor subtypes really occur in the brain? Trends Neurosci 19: 139-143.
19. A receptor populations with novel subunit combinations and drug binding profiles identified in brain by α5- and α-subunit-specific immunopurification. J Biol Chem 268:5965-5973.
20. Mihic SJ, Whiting PJ, Klein RL, Wafford KA, Harris RA. 1994. A single amino acid of the human γ-aminobutyric acid type A receptor γ2 subunit determines benzodiazepine efficacy. J Biol Chem 269:32768-32773.
21. A receptors: from subunits to diverse functions. In: Narahashi, T, editor. Ion channels. Vol. 4. New York: Plenum Press, p 89-113.
22. Ogurusu T, Shingai R. 1996. Cloning of a putative γ-aminobutyric acid (GABA) receptor subunitp3 cDNA. Biochim Biophys Acta 1305:15-18.
23. Pan ZH, Zhang D, Zhang X, Lipton SA. 1997. Agonist-induced closure of constitutively open γ-aminobutyric acid channels with mutated M2 domains. Proc Natl Acad Sci USA 94:6490-6495.
24. Polenzani L, Woodward RM, Miledi R. 1991. Expression of mammalian γ-aminobutyric acid receptors with distinct pharmacology in Xenopus oocytes. Proc Natl Acad Sci USA 88:4318-4322.
25. Pritchett DB, Seeburg PH. 1991. γ-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site. Proc Natl Acad Sci USA 88:1421-1425.
26. Qian H, Dowling JE. 1993. Novel GABA responses from rod-driven retinal horizontal cells. Nature 361:162-164.
27. Qian H, Dowling JE. 1994. Pharmacology of novel GABA receptors found on rod horizontal cells of the white perch retina. J Neurosci 14:4299-4307.
28. C receptors on hybrid bass retinal bipolar cells. J Neurophysiol 74: 1920-1928.
29. Qian H, Dowling JE, Ripps H. 1998. Molecular and pharmacological properties of GABA-p subunits from white perch retina. J Neurobiol 37:305-320.
30. Qian H, Hyatt G, Schanzer A, Hazra R. Hackam AS, Cutting GR, Dowling JE. 1997. A comparison of GABAC and rho subunit receptors from the white perch retina. Vis Neurosci 14:843-851.
31. Shimada S, Cutting G, Uhl GR. 1992. γ-Aminobutyric acid A or C receptor? γ-Aminobutyric acid p1 receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-insensitive γ-aminobutyric acid responses in Xenopus oocytes. Mol Pharmacol 41:683-687.
32. Unwin N. 1995. Acetylcholine receptor channel imaged in the open state. Nature 373:37-43.
33. Wang TL, Guggino WB, Cutting GR. 1994. A novel gamma-aminobutyric acid receptor subunit (p2) cloned from human retina forms bicuculline-insensitive homooligomeric receptors in Xenopus oocytes. J Neurosci 14:6524-6531.
34. A receptor subtypes. Int Rev Neurobiol 38:95-138.
35. Zhang D, Pan ZH, Zhang X, Brideau AD, Lipton SA. 1995. Cloning of a γ-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block. Proc Natl Acad Sci USA 92: 11756-11760.