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Volumn 95, Issue 4, 2012, Pages 507-516

Impaired sonic hedgehog pathway contributes to cardiac dysfunction in type 1 diabetic mice with myocardial infarction

Author keywords

Cardiac dysfunction; Diabetes; Myocardial infarction; Sonic hedgehog pathway

Indexed keywords

PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

EID: 84865264805     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs216     Document Type: Article
Times cited : (42)

References (53)
  • 1
    • 0037629251 scopus 로고    scopus 로고
    • Demographics and concomitant disorders in heart failure
    • Krum H, Gilbert RE. Demographics and concomitant disorders in heart failure. Lancet 2003;362:147-158.
    • (2003) Lancet , vol.362 , pp. 147-158
    • Krum, H.1    Gilbert, R.E.2
  • 2
    • 70350566100 scopus 로고    scopus 로고
    • The ubiquitin-proteasome system contributes to the inflammatory injury in ischemic diabetic myocardium: The role of glycemic control
    • Marfella R, Di Filippo C, Portoghese M, Siniscalchi M, Martis S, Ferraraccio F et al. The ubiquitin-proteasome system contributes to the inflammatory injury in ischemic diabetic myocardium: the role of glycemic control. Cardiovasc Pathol 2009;18:332-345.
    • (2009) Cardiovasc Pathol , vol.18 , pp. 332-345
    • Marfella, R.1    Di Filippo, C.2    Portoghese, M.3    Siniscalchi, M.4    Martis, S.5    Ferraraccio, F.6
  • 3
    • 44949114361 scopus 로고    scopus 로고
    • Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: Implications for diabetic ventricular dysfunction after myocardial infarction
    • Shishido T, Woo CH, Ding B, McClain C, Molina CA, Yan C et al. Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction. Circ Res 2008;102: 1416-1425.
    • (2008) Circ Res , vol.102 , pp. 1416-1425
    • Shishido, T.1    Woo, C.H.2    Ding, B.3    McClain, C.4    Molina, C.A.5    Yan, C.6
  • 5
    • 77950496435 scopus 로고    scopus 로고
    • Thioredoxin-1 gene therapy enhances angiogenic signaling and reduces ventricular remodeling in infarcted myocardium of diabetic rats
    • Samuel SM, Thirunavukkarasu M, Penumathsa SV, Koneru S, Zhan L, Maulik G et al. Thioredoxin-1 gene therapy enhances angiogenic signaling and reduces ventricular remodeling in infarcted myocardium of diabetic rats. Circulation 2010;121:1244-1255.
    • (2010) Circulation , vol.121 , pp. 1244-1255
    • Samuel, S.M.1    Thirunavukkarasu, M.2    Penumathsa, S.V.3    Koneru, S.4    Zhan, L.5    Maulik, G.6
  • 6
    • 14644431753 scopus 로고    scopus 로고
    • Hyper-glycemia in streptozotocin-induced diabetic rat increases infarct size associated with low levels of myocardial HO-1 during ischemia/reperfusion
    • Di Filippo C, Marfella R, Cuzzocrea S, Piegari E, Petronella P, Giugliano D et al. Hyper-glycemia in streptozotocin-induced diabetic rat increases infarct size associated with low levels of myocardial HO-1 during ischemia/reperfusion. Diabetes 2005;54: 803-810.
    • (2005) Diabetes , vol.54 , pp. 803-810
    • Di Filippo, C.1    Marfella, R.2    Cuzzocrea, S.3    Piegari, E.4    Petronella, P.5    Giugliano, D.6
  • 7
    • 0036373441 scopus 로고    scopus 로고
    • Myocardial infarction in diabetic rats: Role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1
    • Marfella R, D'Amico M, Di Filippo C, Piegari E, Nappo F, Esposito K et al. Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1. Diabetologia 2002;45:1172-1181.
    • (2002) Diabetologia , vol.45 , pp. 1172-1181
    • Marfella, R.1    D'Amico, M.2    Di Filippo, C.3    Piegari, E.4    Nappo, F.5    Esposito, K.6
  • 10
    • 0037769109 scopus 로고    scopus 로고
    • The Hedgehog signaling pathway-implications for drug targets in cancer and neurodegenerative disorders
    • Bak M, Hansen C, Tommerup N, Larsen LA. The Hedgehog signaling pathway-implications for drug targets in cancer and neurodegenerative disorders. Pharmacogenomics 2003;4:411-429.
    • (2003) Pharmacogenomics , vol.4 , pp. 411-429
    • Bak, M.1    Hansen, C.2    Tommerup, N.3    Larsen, L.A.4
  • 12
    • 27744584084 scopus 로고    scopus 로고
    • Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway
    • Paladini RD, Saleh J, Qian C, Xu GX, Rubin LL. Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway. J Invest Dermatol 2005;125: 638-646.
    • (2005) J Invest Dermatol , vol.125 , pp. 638-646
    • Paladini, R.D.1    Saleh, J.2    Qian, C.3    Xu, G.X.4    Rubin, L.L.5
  • 13
    • 0002452569 scopus 로고    scopus 로고
    • Developmental roles and clinical significance of hedgehog signaling
    • McMahon AP, Ingham PW, Tabin CJ. Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol 2003;53:1-114.
    • (2003) Curr Top Dev Biol , vol.53 , pp. 1-114
    • McMahon, A.P.1    Ingham, P.W.2    Tabin, C.J.3
  • 14
    • 34247843997 scopus 로고    scopus 로고
    • Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review)
    • Katoh Y, Katoh M. Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). Int J Mol Med 2006;18:1019-1023.
    • (2006) Int J Mol Med , vol.18 , pp. 1019-1023
    • Katoh, Y.1    Katoh, M.2
  • 16
    • 69549130773 scopus 로고    scopus 로고
    • SHH pathway and cerebellar development
    • Vaillant C, Monard D. SHH pathway and cerebellar development. Cerebellum 2009;8: 291-301.
    • (2009) Cerebellum , vol.8 , pp. 291-301
    • Vaillant, C.1    Monard, D.2
  • 17
    • 0034960583 scopus 로고    scopus 로고
    • The morpho-gen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angio-genic growth factors
    • Pola R, Ling LE, Silver M, Corbley MJ, Kearney M, Blake Pepinsky R et al. The morpho-gen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angio-genic growth factors. Nat Med 2001;7:706-711.
    • (2001) Nat Med , vol.7 , pp. 706-711
    • Pola, R.1    Ling, L.E.2    Silver, M.3    Corbley, M.J.4    Kearney, M.5    Blake Pepinsky, R.6
  • 18
    • 30744466891 scopus 로고    scopus 로고
    • Sonic hedgehog myocardial gene therapy: Tissue repair through transient reconstitution of embryonic signaling
    • Kusano KF, Pola R, Murayama T, Curry C, Kawamoto A, Iwakura A et al. Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling. Nat Med 2005;11:1197-1204.
    • (2005) Nat Med , vol.11 , pp. 1197-1204
    • Kusano, K.F.1    Pola, R.2    Murayama, T.3    Curry, C.4    Kawamoto, A.5    Iwakura, A.6
  • 19
    • 0042711211 scopus 로고    scopus 로고
    • Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia
    • Pola R, Ling LE, Aprahamian TR, Barban E, Bosch-Marce M, Curry C et al. Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia. Circulation 2003;108:479-485.
    • (2003) Circulation , vol.108 , pp. 479-485
    • Pola, R.1    Ling, L.E.2    Aprahamian, T.R.3    Barban, E.4    Bosch-Marce, M.5    Curry, C.6
  • 20
    • 33744466786 scopus 로고    scopus 로고
    • Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling
    • Asai J, Takenaka H, Kusano KF, Ii M, Luedemann C, Curry C et al. Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation 2006;113:2413-2424.
    • (2006) Circulation , vol.113 , pp. 2413-2424
    • Asai, J.1    Takenaka, H.2    Kusano, K.F.3    Ii, M.4    Luedemann, C.5    Curry, C.6
  • 22
    • 0042863050 scopus 로고    scopus 로고
    • Altered Sonic hedgehog signaling is associated with morphological abnormalities in the penis of the BB/WOR diabetic rat
    • Podlasek CA, Zelner DJ, Harris JD, Meroz CL, Tang Y, McKenna KE et al. Altered Sonic hedgehog signaling is associated with morphological abnormalities in the penis of the BB/WOR diabetic rat. Biol Reprod 2003;69:816-827.
    • (2003) Biol Reprod , vol.69 , pp. 816-827
    • Podlasek, C.A.1    Zelner, D.J.2    Harris, J.D.3    Meroz, C.L.4    Tang, Y.5    McKenna, K.E.6
  • 24
    • 68049091808 scopus 로고    scopus 로고
    • Sonic hedgehog improves delayed wound healing via enhancing cutaneous nitric oxide function in diabetes
    • Luo JD, Hu TP, Wang L, Chen MS, Liu SM, Chen AF. Sonic hedgehog improves delayed wound healing via enhancing cutaneous nitric oxide function in diabetes. Am J Physiol Endocrinol Metab 2009;297:E525-E531.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Luo, J.D.1    Hu, T.P.2    Wang, L.3    Chen, M.S.4    Liu, S.M.5    Chen, A.F.6
  • 25
    • 46849087764 scopus 로고    scopus 로고
    • Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice
    • Lavine KJ, Kovacs A, Ornitz DM. Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice. J Clin Invest 2008;118:2404-2414.
    • (2008) J Clin Invest , vol.118 , pp. 2404-2414
    • Lavine, K.J.1    Kovacs, A.2    Ornitz, D.M.3
  • 26
    • 6444226659 scopus 로고    scopus 로고
    • Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice
    • Luo JD, Wang YY, Fu WL, Wu J, Chen AF. Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice. Circulation 2004;110:2484-2493.
    • (2004) Circulation , vol.110 , pp. 2484-2493
    • Luo, J.D.1    Wang, Y.Y.2    Fu, W.L.3    Wu, J.4    Chen, A.F.5
  • 27
  • 29
    • 1542319162 scopus 로고    scopus 로고
    • Mouse cardiac surgery: Comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies
    • Tarnavski O, McMullen JR, Schinke M, Nie Q, Kong S, Izumo S. Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies. Physiol Genomics 2004;16:349-360.
    • (2004) Physiol Genomics , vol.16 , pp. 349-360
    • Tarnavski, O.1    McMullen, J.R.2    Schinke, M.3    Nie, Q.4    Kong, S.5    Izumo, S.6
  • 30
    • 77953223654 scopus 로고    scopus 로고
    • Sonic hedgehog is a critical mediator of erythropoietin-induced cardiac protection in mice
    • Ueda K, Takano H, Niitsuma Y, Hasegawa H, Uchiyama R, Oka T et al. Sonic hedgehog is a critical mediator of erythropoietin-induced cardiac protection in mice. J Clin Invest 2010;120:2016-2029.
    • (2010) J Clin Invest , vol.120 , pp. 2016-2029
    • Ueda, K.1    Takano, H.2    Niitsuma, Y.3    Hasegawa, H.4    Uchiyama, R.5    Oka, T.6
  • 31
    • 59849089688 scopus 로고    scopus 로고
    • IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR
    • Krishnamurthy P, Rajasingh J, Lambers E, Qin G, Losordo DW, Kishore R. IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR. Circ Res 2009;104:e9-e18.
    • (2009) Circ Res , vol.104
    • Krishnamurthy, P.1    Rajasingh, J.2    Lambers, E.3    Qin, G.4    Losordo, D.W.5    Kishore, R.6
  • 33
    • 38149027631 scopus 로고    scopus 로고
    • Cyclopamine inhibition of the sonic hedgehog pathway in the stomach requires concomitant acid inhibition
    • El-Zaatari M, Grabowska AM, McKenzie AJ, Powe DG, Scotting PJ, Watson SA. Cyclopamine inhibition of the sonic hedgehog pathway in the stomach requires concomitant acid inhibition. Regul Pept 2008;146:131-139.
    • (2008) Regul Pept , vol.146 , pp. 131-139
    • El-Zaatari, M.1    Grabowska, A.M.2    McKenzie, A.J.3    Powe, D.G.4    Scotting, P.J.5    Watson, S.A.6
  • 34
    • 34047132909 scopus 로고    scopus 로고
    • Rebuilding the coronary vasculature: Hedgehog as a new candidate for pharmacologic revascularization
    • Lavine KJ, Ornitz DM. Rebuilding the coronary vasculature: hedgehog as a new candidate for pharmacologic revascularization. Trends Cardiovasc Med 2007;17:77-83.
    • (2007) Trends Cardiovasc Med , vol.17 , pp. 77-83
    • Lavine, K.J.1    Ornitz, D.M.2
  • 35
    • 59849089050 scopus 로고    scopus 로고
    • Review-Shared circuitry: Developmental signaling cascades regulate both embryonic and adult coronary vasculature
    • Lavine KJ, Ornitz DM. Review-Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature. Circ Res 2009;104:159-169.
    • (2009) Circ Res , vol.104 , pp. 159-169
    • Lavine, K.J.1    Ornitz, D.M.2
  • 36
    • 34347395136 scopus 로고    scopus 로고
    • Signal transduction in early heart development (I): Cardio-genic induction and heart tube formation
    • Wagner M, Siddiqui MA. Signal transduction in early heart development (I): cardio-genic induction and heart tube formation. Exp Biol Med (Maywood) 2007;232:852-865.
    • (2007) Exp Biol Med (Maywood) , vol.232 , pp. 852-865
    • Wagner, M.1    Siddiqui, M.A.2
  • 37
    • 65449133141 scopus 로고    scopus 로고
    • Signaling pathways controlling second heart field development
    • Rochais F, Mesbah K, Kelly RG. Signaling pathways controlling second heart field development. Circ Res 2009;104:933-942.
    • (2009) Circ Res , vol.104 , pp. 933-942
    • Rochais, F.1    Mesbah, K.2    Kelly, R.G.3
  • 38
    • 79958295157 scopus 로고    scopus 로고
    • Sonic hedgehog-induced functional recovery after myocardial infarction is enhanced by AMD3100-mediated progenitor-cell mobilization
    • Roncalli J, Renault MA, Tongers J, Misener S, Thorne T, Kamide C et al. Sonic hedgehog-induced functional recovery after myocardial infarction is enhanced by AMD3100-mediated progenitor-cell mobilization. J Am Coll Cardiol 2011;57: 2444-2452.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 2444-2452
    • Roncalli, J.1    Renault, M.A.2    Tongers, J.3    Misener, S.4    Thorne, T.5    Kamide, C.6
  • 39
    • 0035368725 scopus 로고    scopus 로고
    • Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
    • Lewis PM, Dunn MP, McMahon JA, Logan M, Martin JF, St-Jacques B et al. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 2001;105:599-612.
    • (2001) Cell , vol.105 , pp. 599-612
    • Lewis, P.M.1    Dunn, M.P.2    McMahon, J.A.3    Logan, M.4    Martin, J.F.5    St-Jacques, B.6
  • 40
    • 34548170996 scopus 로고    scopus 로고
    • The sonic hedgehog signaling network in development and neoplasia
    • Chari NS, McDonnell TJ. The sonic hedgehog signaling network in development and neoplasia. Adv Anat Pathol 2007;14:344-352.
    • (2007) Adv Anat Pathol , vol.14 , pp. 344-352
    • Chari, N.S.1    McDonnell, T.J.2
  • 42
    • 72449209673 scopus 로고    scopus 로고
    • Sonic hedgehog is a potent chemoattractant for human monocytes: Diabetes mellitus inhibits Sonic hedgehog-induced monocyte chemotaxis
    • Dunaeva M, Voo S, van Oosterhoud C, Waltenberger J. Sonic hedgehog is a potent chemoattractant for human monocytes: diabetes mellitus inhibits Sonic hedgehog-induced monocyte chemotaxis. Basic Res Cardiol 2010;105:61-71.
    • (2010) Basic Res Cardiol , vol.105 , pp. 61-71
    • Dunaeva, M.1    Voo, S.2    Van Oosterhoud, C.3    Waltenberger, J.4
  • 43
    • 78349297565 scopus 로고    scopus 로고
    • Oxidative stress and diabetic complications
    • Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res 2010;107: 1058-1070.
    • (2010) Circ Res , vol.107 , pp. 1058-1070
    • Giacco, F.1    Brownlee, M.2
  • 45
    • 0036230482 scopus 로고    scopus 로고
    • Acute hyperglycemia induces nitrotyrosine formation and apoptosis in perfused heart from rat
    • Ceriello A, Quagliaro L, D'Amico M, Di Filippo C, Marfella R, Nappo F et al. Acute hyperglycemia induces nitrotyrosine formation and apoptosis in perfused heart from rat. Diabetes 2002;51:1076-1082.
    • (2002) Diabetes , vol.51 , pp. 1076-1082
    • Ceriello, A.1    Quagliaro, L.2    D'Amico, M.3    Di Filippo, C.4    Marfella, R.5    Nappo, F.6
  • 46
    • 34248512606 scopus 로고    scopus 로고
    • Nitric oxide regulates expression of sonic hedgehog and hypoxia-inducible factor-1a in an experimental model of kidney ischemia-reperfusion
    • Ozturk H, Tuncer MC, Buyukbayram H. Nitric oxide regulates expression of sonic hedgehog and hypoxia-inducible factor-1a in an experimental model of kidney ischemia-reperfusion. Ren Fail 2007;29:249-256.
    • (2007) Ren Fail , vol.29 , pp. 249-256
    • Ozturk, H.1    Tuncer, M.C.2    Buyukbayram, H.3
  • 47
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001;414:813-820.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 48
    • 0037327402 scopus 로고    scopus 로고
    • Oxidative stress and diabetic neuropathy: A new understanding of an old problem
    • Feldman EL. Oxidative stress and diabetic neuropathy: a new understanding of an old problem. J Clin Invest 2003;111:431-433.
    • (2003) J Clin Invest , vol.111 , pp. 431-433
    • Feldman, E.L.1
  • 49
    • 78649875480 scopus 로고    scopus 로고
    • Hedgehog signaling and osteo-genic differentiation in multipotent bone marrow stromal cells are inhibited by oxida-tive stress
    • Kim WK, Meliton V, Bourquard N, Hahn TJ, Parhami F. Hedgehog signaling and osteo-genic differentiation in multipotent bone marrow stromal cells are inhibited by oxida-tive stress. J Cell Biochem 2010;111:1199-1209.
    • (2010) J Cell Biochem , vol.111 , pp. 1199-1209
    • Kim, W.K.1    Meliton, V.2    Bourquard, N.3    Hahn, T.J.4    Parhami, F.5
  • 50
    • 0035958941 scopus 로고    scopus 로고
    • Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node
    • Zhang XM, Ramalho-Santos M, McMahon AP. Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 2001;106:781-792.
    • (2001) Cell , vol.106 , pp. 781-792
    • Zhang, X.M.1    Ramalho-Santos, M.2    McMahon, A.P.3
  • 51
    • 59849089050 scopus 로고    scopus 로고
    • Shared circuitry: Developmental signaling cascades regulate both embryonic and adult coronary vasculature
    • Lavine KJ, Ornitz DM. Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature. Circ Res 2009;104:159-169.
    • (2009) Circ Res , vol.104 , pp. 159-169
    • Lavine, K.J.1    Ornitz, D.M.2
  • 52
    • 49949115945 scopus 로고    scopus 로고
    • Intra-cardiac septation requires hedgehog-dependent cellular contributions from outside the heart
    • Goddeeris MM, Rho S, Petiet A, Davenport CL, Johnson GA, Meyers EN et al. Intra-cardiac septation requires hedgehog-dependent cellular contributions from outside the heart. Development 2008;135:1887-1895.
    • (2008) Development , vol.135 , pp. 1887-1895
    • Goddeeris, M.M.1    Rho, S.2    Petiet, A.3    Davenport, C.L.4    Johnson, G.A.5    Meyers, E.N.6


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