A model reaction assesses contribution of H-tunneling and coupled motions to enzyme catalysis

Journal of Organic Chemistry

Volumn 77, Issue 16, 2012, Pages 6825-6833

  Liu, Qi ^a   Zhao, Yu ^a   Hammann, Blake ^a   Eilers, James ^a   Lu, Yun ^a   Kohen, Amnon ^b  

^a SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE   (United States)

^b University of Iowa   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; ALCOHOL OXIDATION; BENZYL ALCOHOL; COMPARATIVE EXPERIMENTS; COUPLED MOTIONS; ENZYMATIC OXIDATIONS; ENZYMATIC REACTION; ENZYME CATALYSIS; EXPERIMENTAL COMPARISON; HYDRIDE TRANSFERS; LINEAR FREE ENERGY; MODEL REACTIONS; PHYSICAL FEATURES; RADICAL REACTIONS; TEMPERATURE DEPENDENT; TRANSITION STATE; UNCATALYZED REACTIONS;

ACETONITRILE; DEUTERIUM COMPOUNDS; ENZYMES; HYDRIDES; ORGANIC SOLVENTS; REACTION KINETICS; REDOX REACTIONS;

CATALYSIS;

9 PHENYLXANTHYLIUM; ACETONITRILE; ALCOHOL DEHYDROGENASE; BENZYL ALCOHOL; CARBON; CATION; HYDROGEN; ISOTOPE; UNCLASSIFIED DRUG; XANTHENE DERIVATIVE;

ALCOHOL OXIDATION; ARTICLE; CATALYSIS; ENZYME MECHANISM; H TUNNELING; HYDROLYSIS; KINETIC ISOTOPE EFFECT; KINETICS; LINEAR ENERGY TRANSFER; MICROSCOPY; OXIDATION; OXIDATION REDUCTION REACTION; RADICAL REACTION; TEMPERATURE;

ACETONITRILES; ALCOHOL DEHYDROGENASE; BENZYL ALCOHOL; BIOCATALYSIS; CATALYSIS; HYDROGEN; KINETICS; MODELS, CHEMICAL; MOTION; NAD; OXIDATION-REDUCTION; PROTEINS; PROTONS; SOLVENTS; TEMPERATURE; THERMODYNAMICS; XANTHENES;

EID: 84865256967     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo300879r     Document Type: Article

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