Gene therapy, angiogenesis, Sonic Hedgehog: Sonic the Hedgehog to the rescue?

Gene Therapy

Volumn 13, Issue 13, 2006, Pages 998-999

  Donahue, J K ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PLACEBO; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; VIRUS VECTOR; ZINC FINGER PROTEIN;

ANGIOGENESIS; CLINICAL TRIAL; DNA LIBRARY; DNA VECTOR; DROSOPHILA MELANOGASTER; GENE THERAPY; GENE TRANSFER; HUMAN; MULTIGENE FAMILY; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STEM CELL TRANSPLANTATION;

ANIMALS; DISEASE MODELS, ANIMAL; GENE THERAPY; HEDGEHOG PROTEINS; MICE; MYOCARDIAL ISCHEMIA;

ERINACEIDAE;

EID: 33745197162     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302748     Document Type: Note

References (11)

1. Sonic Games: Genesis [online]. 2005, [cited 2005 Dec 2]. http://www.sega.com/sonic/content.php.
2. SegaSammy Holdings Financial Report. 2005, [cited 2005 Dec 2]. http://www.segasammy.co.jp/english/ir/report_highlight.html.
3. Riddle RD, Johnson RL, Laufer E, Tabin C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 1993; 75: 1401-1416.
4. Cohen Jr MM. The hedgehog signaling network. Am J Med Genet A 2003; 123: 5-28.
5. Villavicencio EH, Walterhouse DO, Iannaccone PM. The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet 2000; 67: 1047-1054.
6. Kusano KF, Pola R, Murayama T, Curry C, Kawamoto A, Iwakura A et al. Sonic hedgehog myocardial gene therapy: Tissue repair through transient reconstitution of embryonic signaling. Nat Med 2005; 11: 1197-1204.
7. Grines CL, Watkins MW, Mahmarian JJ, Iskandrian AE, Rade JJ, Marrott P et al., Angiogene GENe Therapy (AGENT-2) Study Group. A randomized, double-blind, placebo-controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina. J Am Coll Cardiol 2003; 42: 1339-1347.
8. Kastrup J, Jorgensen E, Ruck A, Tagil K, Glogar D, Ruzyllo W et al., Euroinject One Group. Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe, angina pectoris. A randomized double-blind placebo-controlled study: The Euroinject One trial. J Am Coll Cardiol 2005; 45: 982-988.
9. Kalka C, Masuda H, Takahashi T, Kalka-Moll WM, Silver M, Kearney M et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci USA 2000; 97: 3422-3427.
10. Vincent KA, Shyu KG, Luo Y, Magner M, Tio RA, Jiang C et al. Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor. Circulation 2000; 102: 2255-2261.
11. Son MK, Choi JH, Lee DS, Kim CY, Choi SM, Kang KK et al. Pharmacokinetics and biodistribution of a pGT2-VEGF plasmid DNA after administration in rats. J Cardiovasc Pharmacol 2005; 46: 577-584.