메뉴 건너뛰기




Volumn 4, Issue 5, 2012, Pages 443-456

The molecular circuitry underlying pluripotency in embryonic stem cells

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIFFERENTIATION; CELL FATE; EMBRYOID BODY; EMBRYONIC STEM CELL; EPIGENETICS; GENE INACTIVATION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; INNER CELL MASS; MOLECULAR BIOLOGY; NONHUMAN; PLURIPOTENT STEM CELL; REVIEW; SIGNAL TRANSDUCTION; STOICHIOMETRY; TERATOMA; TETRAPLOIDY;

EID: 84865171597     PISSN: 19395094     EISSN: 1939005X     Source Type: Journal    
DOI: 10.1002/wsbm.1182     Document Type: Review
Times cited : (11)

References (137)
  • 1
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos.
    • Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981, 292: 154-156.
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 2
    • 0001007610 scopus 로고
    • Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.
    • Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A 1981, 78:7634-7638.
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 7634-7638
    • Martin, G.R.1
  • 5
    • 0027321548 scopus 로고
    • Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.
    • Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A 1993, 90: 8424-8428.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 8424-8428
    • Nagy, A.1    Rossant, J.2    Nagy, R.3    Abramow-Newerly, W.4    Roder, J.C.5
  • 6
    • 33745879486 scopus 로고    scopus 로고
    • Contribution of human embryonic stem cells to mouse blastocysts.
    • James D, Noggle SA, Swigut T, Brivanlou AH. Contribution of human embryonic stem cells to mouse blastocysts. Dev Biol 2006, 295: 90-102.
    • (2006) Dev Biol , vol.295 , pp. 90-102
    • James, D.1    Noggle, S.A.2    Swigut, T.3    Brivanlou, A.H.4
  • 7
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126: 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 8
    • 0024245022 scopus 로고
    • Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides.
    • Smith AG, Heath JK, Donaldson DD, Wong GG, Moreau J, Stahl M, Rogers D. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 1988, 336: 688-690.
    • (1988) Nature , vol.336 , pp. 688-690
    • Smith, A.G.1    Heath, J.K.2    Donaldson, D.D.3    Wong, G.G.4    Moreau, J.5    Stahl, M.6    Rogers, D.7
  • 9
    • 0032127977 scopus 로고    scopus 로고
    • Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3.
    • Niwa H, Burdon T, Chambers I, Smith A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev 1998, 12: 2048-2060.
    • (1998) Genes Dev , vol.12 , pp. 2048-2060
    • Niwa, H.1    Burdon, T.2    Chambers, I.3    Smith, A.4
  • 10
    • 67650032868 scopus 로고    scopus 로고
    • A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells.
    • Niwa H, Ogawa K, Shimosato D, Adachi K. A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature 2009, 460: 118-122.
    • (2009) Nature , vol.460 , pp. 118-122
    • Niwa, H.1    Ogawa, K.2    Shimosato, D.3    Adachi, K.4
  • 11
    • 0344845415 scopus 로고    scopus 로고
    • BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3.
    • Ying QL, Nichols J, Chambers I, Smith A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003, 115: 281-292.
    • (2003) Cell , vol.115 , pp. 281-292
    • Ying, Q.L.1    Nichols, J.2    Chambers, I.3    Smith, A.4
  • 15
    • 1242267927 scopus 로고    scopus 로고
    • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor.
    • Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 2004, 10: 55-63.
    • (2004) Nat Med , vol.10 , pp. 55-63
    • Sato, N.1    Meijer, L.2    Skaltsounis, L.3    Greengard, P.4    Brivanlou, A.H.5
  • 17
    • 79952161362 scopus 로고    scopus 로고
    • FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation.
    • Yu P, Pan G, Yu J, Thomson JA. FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation. Cell Stem Cell 2011, 8: 326-334.
    • (2011) Cell Stem Cell , vol.8 , pp. 326-334
    • Yu, P.1    Pan, G.2    Yu, J.3    Thomson, J.A.4
  • 19
  • 21
    • 27644486756 scopus 로고    scopus 로고
    • Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.
    • Vallier L, Alexander M, Pedersen RA. Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J Cell Sci 2005, 118: 4495-4509.
    • (2005) J Cell Sci , vol.118 , pp. 4495-4509
    • Vallier, L.1    Alexander, M.2    Pedersen, R.A.3
  • 22
    • 16244400050 scopus 로고    scopus 로고
    • TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells.
    • James D, Levine AJ, Besser D, Hemmati-Brivanlou A. TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 2005, 132: 1273-1282.
    • (2005) Development , vol.132 , pp. 1273-1282
    • James, D.1    Levine, A.J.2    Besser, D.3    Hemmati-Brivanlou, A.4
  • 23
    • 16444373230 scopus 로고    scopus 로고
    • Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layers.
    • Beattie GM, Lopez AD, Bucay N, Hinton A, Firpo MT, King CC, Hayek A. Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layers. Stem Cells 2005, 23: 489-495.
    • (2005) Stem Cells , vol.23 , pp. 489-495
    • Beattie, G.M.1    Lopez, A.D.2    Bucay, N.3    Hinton, A.4    Firpo, M.T.5    King, C.C.6    Hayek, A.7
  • 24
    • 33747614295 scopus 로고    scopus 로고
    • Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells.
    • Xiao L, Yuan X, Sharkis SJ. Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells. Stem Cells 2006, 24: 1476-1486.
    • (2006) Stem Cells , vol.24 , pp. 1476-1486
    • Xiao, L.1    Yuan, X.2    Sharkis, S.J.3
  • 28
    • 78149487692 scopus 로고    scopus 로고
    • Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues.
    • Hanna JH, Saha K, Jaenisch R. Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell 2010, 143: 508-525.
    • (2010) Cell , vol.143 , pp. 508-525
    • Hanna, J.H.1    Saha, K.2    Jaenisch, R.3
  • 29
    • 77958569435 scopus 로고    scopus 로고
    • Induced pluripotency: history, mechanisms, and applications.
    • Stadtfeld M, Hochedlinger K. Induced pluripotency: history, mechanisms, and applications. Genes Dev 2010, 24: 2239-2263.
    • (2010) Genes Dev , vol.24 , pp. 2239-2263
    • Stadtfeld, M.1    Hochedlinger, K.2
  • 31
    • 79959733972 scopus 로고    scopus 로고
    • Activin/TGF-beta signaling regulates Nanog expression in the epiblast during gastrulation.
    • Shin M, Alev C, Wu Y, Nagai H, Sheng G. Activin/TGF-beta signaling regulates Nanog expression in the epiblast during gastrulation. Mech Dev 2011, 128: 268-278.
    • (2011) Mech Dev , vol.128 , pp. 268-278
    • Shin, M.1    Alev, C.2    Wu, Y.3    Nagai, H.4    Sheng, G.5
  • 33
    • 84863241921 scopus 로고    scopus 로고
    • Signaling network crosstalk in human pluripotent cells: a smad2/3-regulated switch that controls the balance between self-renewal and differentiation.
    • Singh AM, Reynolds D, Cliff T, Ohtsuka S, Mattheyses AL, Sun Y, Menendez L, Kulik M, Dalton S. Signaling network crosstalk in human pluripotent cells: a smad2/3-regulated switch that controls the balance between self-renewal and differentiation. Cell Stem Cell 2012, 10: 312-326.
    • (2012) Cell Stem Cell , vol.10 , pp. 312-326
    • Singh, A.M.1    Reynolds, D.2    Cliff, T.3    Ohtsuka, S.4    Mattheyses, A.L.5    Sun, Y.6    Menendez, L.7    Kulik, M.8    Dalton, S.9
  • 34
    • 77952345331 scopus 로고    scopus 로고
    • The role of SMAD4 in human embryonic stem cell self-renewal and stem cell fate.
    • Avery S, Zafarana G, Gokhale PJ, Andrews PW. The role of SMAD4 in human embryonic stem cell self-renewal and stem cell fate. Stem Cells 2010, 28: 863-873.
    • (2010) Stem Cells , vol.28 , pp. 863-873
    • Avery, S.1    Zafarana, G.2    Gokhale, P.J.3    Andrews, P.W.4
  • 35
    • 0030663881 scopus 로고    scopus 로고
    • Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads.
    • Candia AF, Watabe T, Hawley SH, Onichtchouk D, Zhang Y, Derynck R, Niehrs C, Cho KW. Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development 1997, 124: 4467-4480.
    • (1997) Development , vol.124 , pp. 4467-4480
    • Candia, A.F.1    Watabe, T.2    Hawley, S.H.3    Onichtchouk, D.4    Zhang, Y.5    Derynck, R.6    Niehrs, C.7    Cho, K.W.8
  • 36
    • 0030773834 scopus 로고    scopus 로고
    • Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1.
    • Kretzschmar M, Doody J, Massagué J. Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 1997, 389: 618-622.
    • (1997) Nature , vol.389 , pp. 618-622
    • Kretzschmar, M.1    Doody, J.2    Massagué, J.3
  • 38
    • 30544450976 scopus 로고    scopus 로고
    • WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells.
    • Hao J, Li T-G, Qi X, Zhao D-F, Zhao G-Q. WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells. Dev Biol 2006, 290: 81-91.
    • (2006) Dev Biol , vol.290 , pp. 81-91
    • Hao, J.1    Li, T.-G.2    Qi, X.3    Zhao, D.-F.4    Zhao, G.-Q.5
  • 41
    • 54949127934 scopus 로고    scopus 로고
    • Periodic activation of Wnt/beta-catenin signaling enhances somatic cell reprogramming mediated by cell fusion.
    • Lluis F, Pedone E, Pepe S, Cosma MP. Periodic activation of Wnt/beta-catenin signaling enhances somatic cell reprogramming mediated by cell fusion. Cell Stem Cell 2008, 3: 493-507.
    • (2008) Cell Stem Cell , vol.3 , pp. 493-507
    • Lluis, F.1    Pedone, E.2    Pepe, S.3    Cosma, M.P.4
  • 42
    • 0026442926 scopus 로고
    • Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm.
    • Green JB, New HV, Smith JC. Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 1992, 71: 731-739.
    • (1992) Cell , vol.71 , pp. 731-739
    • Green, J.B.1    New, H.V.2    Smith, J.C.3
  • 43
    • 8444237836 scopus 로고    scopus 로고
    • Dorsal-ventral patterning and neural induction in Xenopus embryos.
    • De Robertis EM, Kuroda H. Dorsal-ventral patterning and neural induction in Xenopus embryos. Annu Rev Cell Dev Biol 2004, 20: 285-308.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 285-308
    • De Robertis, E.M.1    Kuroda, H.2
  • 44
    • 0030886059 scopus 로고    scopus 로고
    • Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1.
    • Wilson PA, Lagna G, Suzuki A, Hemmati-Brivanlou A. Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. Development 1997, 124: 3177-3184.
    • (1997) Development , vol.124 , pp. 3177-3184
    • Wilson, P.A.1    Lagna, G.2    Suzuki, A.3    Hemmati-Brivanlou, A.4
  • 45
    • 33646133209 scopus 로고    scopus 로고
    • Patterning the early Xenopus embryo.
    • Heasman J. Patterning the early Xenopus embryo. Development 2006, 133: 1205-1217.
    • (2006) Development , vol.133 , pp. 1205-1217
    • Heasman, J.1
  • 46
    • 0029148342 scopus 로고
    • Ventral mesodermal patterning in Xenopus embryos: expression patterns and activities of BMP-2 and BMP-4.
    • Hemmati-Brivanlou A, Thomsen GH. Ventral mesodermal patterning in Xenopus embryos: expression patterns and activities of BMP-2 and BMP-4. Dev Genet 1995, 17: 78-89.
    • (1995) Dev Genet , vol.17 , pp. 78-89
    • Hemmati-Brivanlou, A.1    Thomsen, G.H.2
  • 47
    • 77950358156 scopus 로고    scopus 로고
    • Retinoic acid orchestrates fibroblast growth factor signalling to drive embryonic stem cell differentiation.
    • Stavridis MP, Collins BJ, Storey KG. Retinoic acid orchestrates fibroblast growth factor signalling to drive embryonic stem cell differentiation. Development 2010, 137: 881-890.
    • (2010) Development , vol.137 , pp. 881-890
    • Stavridis, M.P.1    Collins, B.J.2    Storey, K.G.3
  • 48
    • 34548587064 scopus 로고    scopus 로고
    • FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment.
    • Kunath T, Saba-El-Leil MK, Almousailleakh M, Wray J, Meloche S, Smith A. FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 2007, 134: 2895-2902.
    • (2007) Development , vol.134 , pp. 2895-2902
    • Kunath, T.1    Saba-El-Leil, M.K.2    Almousailleakh, M.3    Wray, J.4    Meloche, S.5    Smith, A.6
  • 51
    • 0035164395 scopus 로고    scopus 로고
    • A morphogen gradient of Wnt/beta-catenin signalling regulates anteroposterior neural patterning in Xenopus.
    • Kiecker C, Niehrs C. A morphogen gradient of Wnt/beta-catenin signalling regulates anteroposterior neural patterning in Xenopus. Development 2001, 128: 4189-4201.
    • (2001) Development , vol.128 , pp. 4189-4201
    • Kiecker, C.1    Niehrs, C.2
  • 53
    • 84855393039 scopus 로고    scopus 로고
    • Concise review: a chemical approach to control cell fate and function.
    • Li W, Jiang K, Ding S. Concise review: a chemical approach to control cell fate and function. Stem Cells 2012, 30: 61-68.
    • (2012) Stem Cells , vol.30 , pp. 61-68
    • Li, W.1    Jiang, K.2    Ding, S.3
  • 54
    • 0029149656 scopus 로고
    • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
    • Winnier G, Blessing M, Labosky PA, Hogan BL. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 1995, 9: 2105-2116.
    • (1995) Genes Dev , vol.9 , pp. 2105-2116
    • Winnier, G.1    Blessing, M.2    Labosky, P.A.3    Hogan, B.L.4
  • 55
    • 79958252915 scopus 로고    scopus 로고
    • Chromatin connections to pluripotency and cellular reprogramming.
    • Orkin SH, Hochedlinger K. Chromatin connections to pluripotency and cellular reprogramming. Cell 2011, 145: 835-850.
    • (2011) Cell , vol.145 , pp. 835-850
    • Orkin, S.H.1    Hochedlinger, K.2
  • 58
    • 77956272401 scopus 로고    scopus 로고
    • Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo.
    • Ahmed K, Dehghani H, Rugg-Gunn P, Fussner E, Rossant J, Bazett-Jones DP. Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. PLoS One 2010, 5: e10531.
    • (2010) PLoS One , vol.5
    • Ahmed, K.1    Dehghani, H.2    Rugg-Gunn, P.3    Fussner, E.4    Rossant, J.5    Bazett-Jones, D.P.6
  • 61
    • 48649091905 scopus 로고    scopus 로고
    • Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency.
    • Chamberlain SJ, Yee D, Magnuson T. Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency. Stem Cells 2008, 26:1496-1505.
    • (2008) Stem Cells , vol.26 , pp. 1496-1505
    • Chamberlain, S.J.1    Yee, D.2    Magnuson, T.3
  • 62
    • 79251591613 scopus 로고    scopus 로고
    • Rapid activation of the bivalent gene Sox21 requires displacement of multiple layers of gene-silencing machinery.
    • Chakravarthy H, Ormsbee BD, Mallanna SK, Rizzino A. Rapid activation of the bivalent gene Sox21 requires displacement of multiple layers of gene-silencing machinery. FASEB J 2011, 25: 206-218.
    • (2011) FASEB J , vol.25 , pp. 206-218
    • Chakravarthy, H.1    Ormsbee, B.D.2    Mallanna, S.K.3    Rizzino, A.4
  • 65
    • 79959891289 scopus 로고    scopus 로고
    • Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities.
    • Agricola E, Randall RA, Gaarenstroom T, Dupont S, Hill CS. Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities. Mol Cell 2011, 43: 85-96.
    • (2011) Mol Cell , vol.43 , pp. 85-96
    • Agricola, E.1    Randall, R.A.2    Gaarenstroom, T.3    Dupont, S.4    Hill, C.S.5
  • 67
    • 70649100427 scopus 로고    scopus 로고
    • Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc.
    • Lin C-H, Lin C, Tanaka H, Fero ML, Eisenman RN. Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One 2009, 4: e7839.
    • (2009) PLoS One , vol.4
    • Lin, C.-H.1    Lin, C.2    Tanaka, H.3    Fero, M.L.4    Eisenman, R.N.5
  • 70
    • 0041560908 scopus 로고    scopus 로고
    • Molecular signature of human embryonic stem cells and its comparison with the mouse.
    • Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH. Molecular signature of human embryonic stem cells and its comparison with the mouse. Dev Biol 2003, 260: 404-413.
    • (2003) Dev Biol , vol.260 , pp. 404-413
    • Sato, N.1    Meijer, L.2    Skaltsounis, L.3    Greengard, P.4    Brivanlou, A.H.5
  • 72
    • 0033538447 scopus 로고    scopus 로고
    • Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells.
    • Hollnagel A, Oehlmann V, Heymer J, Rüther U, Nordheim A. Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem 1999, 274: 19838-19845.
    • (1999) J Biol Chem , vol.274 , pp. 19838-19845
    • Hollnagel, A.1    Oehlmann, V.2    Heymer, J.3    Rüther, U.4    Nordheim, A.5
  • 73
    • 55049125241 scopus 로고    scopus 로고
    • Regulation of embryonic stem cell self-renewal and pluripotency by Foxd3.
    • Liu Y, Labosky PA. Regulation of embryonic stem cell self-renewal and pluripotency by Foxd3. Stem Cells (Dayton, Ohio) 2008, 26: 2475-2484.
    • (2008) Stem Cells (Dayton, Ohio) , vol.26 , pp. 2475-2484
    • Liu, Y.1    Labosky, P.A.2
  • 74
    • 0037108047 scopus 로고    scopus 로고
    • Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo.
    • Hanna LA, Foreman RK, Tarasenko IA, Kessler DS, Labosky PA. Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev 2002, 16: 2650-2661.
    • (2002) Genes Dev , vol.16 , pp. 2650-2661
    • Hanna, L.A.1    Foreman, R.K.2    Tarasenko, I.A.3    Kessler, D.S.4    Labosky, P.A.5
  • 78
    • 48749119626 scopus 로고    scopus 로고
    • Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells.
    • Fong H, Hohenstein KA, Donovan PJ. Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells (Dayton, Ohio) 2008, 26: 1931-1938.
    • (2008) Stem Cells (Dayton, Ohio) , vol.26 , pp. 1931-1938
    • Fong, H.1    Hohenstein, K.A.2    Donovan, P.J.3
  • 80
    • 1442311693 scopus 로고    scopus 로고
    • Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells.
    • Hay DC, Sutherland L, Clark J, Burdon T. Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells. Stem Cells (Dayton, Ohio) 2004, 22: 225-235.
    • (2004) Stem Cells (Dayton, Ohio) , vol.22 , pp. 225-235
    • Hay, D.C.1    Sutherland, L.2    Clark, J.3    Burdon, T.4
  • 82
    • 0027959928 scopus 로고
    • Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation.
    • Palmieri SL, Peter W, Hess H, Schöler HR. Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol 1994, 166: 259-267.
    • (1994) Dev Biol , vol.166 , pp. 259-267
    • Palmieri, S.L.1    Peter, W.2    Hess, H.3    Schöler, H.R.4
  • 84
    • 0038143611 scopus 로고    scopus 로고
    • Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.
    • Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, Smith A. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003, 113: 643-655.
    • (2003) Cell , vol.113 , pp. 643-655
    • Chambers, I.1    Colby, D.2    Robertson, M.3    Nichols, J.4    Lee, S.5    Tweedie, S.6    Smith, A.7
  • 85
    • 0033679346 scopus 로고    scopus 로고
    • Oct-4 expression in inner cell mass and trophectoderm of human blastocysts.
    • Hansis C, Grifo JA, Krey LC. Oct-4 expression in inner cell mass and trophectoderm of human blastocysts. Mol Hum Reprod 2000, 6: 999-1004.
    • (2000) Mol Hum Reprod , vol.6 , pp. 999-1004
    • Hansis, C.1    Grifo, J.A.2    Krey, L.C.3
  • 87
    • 45249117247 scopus 로고    scopus 로고
    • Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data.
    • Sharov AA, Masui S, Sharova LV, Piao Y, Aiba K, Matoba R, Xin L, Niwa H, Ko MSH. Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data. BMC Genomics 2008, 9: 269.
    • (2008) BMC Genomics , vol.9 , pp. 269
    • Sharov, A.A.1    Masui, S.2    Sharova, L.V.3    Piao, Y.4    Aiba, K.5    Matoba, R.6    Xin, L.7    Niwa, H.8    Ko, M.S.H.9
  • 90
  • 91
    • 0032797827 scopus 로고    scopus 로고
    • The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2.
    • Nishimoto M, Fukushima A, Okuda A, Muramatsu M. The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2. Mol Cell Biol 1999, 19: 5453-5465.
    • (1999) Mol Cell Biol , vol.19 , pp. 5453-5465
    • Nishimoto, M.1    Fukushima, A.2    Okuda, A.3    Muramatsu, M.4
  • 93
    • 0030820931 scopus 로고    scopus 로고
    • Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites.
    • Ambrosetti DC, Basilico C, Dailey L. Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites. Mol Cell Biol 1997, 17: 6321-6329.
    • (1997) Mol Cell Biol , vol.17 , pp. 6321-6329
    • Ambrosetti, D.C.1    Basilico, C.2    Dailey, L.3
  • 97
    • 41149174852 scopus 로고    scopus 로고
    • Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells.
    • Cole MF, Johnstone SE, Newman JJ, Kagey MH, Young RA. Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev 2008, 22: 746-755.
    • (2008) Genes Dev , vol.22 , pp. 746-755
    • Cole, M.F.1    Johnstone, S.E.2    Newman, J.J.3    Kagey, M.H.4    Young, R.A.5
  • 98
    • 79959963618 scopus 로고    scopus 로고
    • Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal.
    • Yi F, Pereira L, Hoffman JA, Shy BR, Yuen CM, Liu DR, Merrill BJ. Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol 2011, 13: 762-770.
    • (2011) Nat Cell Biol , vol.13 , pp. 762-770
    • Yi, F.1    Pereira, L.2    Hoffman, J.A.3    Shy, B.R.4    Yuen, C.M.5    Liu, D.R.6    Merrill, B.J.7
  • 99
    • 79959950773 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation.
    • Wray J, Kalkan T, Gomez-Lopez S, Eckardt D, Cook A, Kemler R, Smith A. Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat Cell Biol 2011, 13: 838-845.
    • (2011) Nat Cell Biol , vol.13 , pp. 838-845
    • Wray, J.1    Kalkan, T.2    Gomez-Lopez, S.3    Eckardt, D.4    Cook, A.5    Kemler, R.6    Smith, A.7
  • 100
    • 48449105489 scopus 로고    scopus 로고
    • Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal.
    • Yi F, Pereira L, Merrill BJ. Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal. Stem Cells (Dayton, Ohio) 2008, 26: 1951-1960.
    • (2008) Stem Cells (Dayton, Ohio) , vol.26 , pp. 1951-1960
    • Yi, F.1    Pereira, L.2    Merrill, B.J.3
  • 101
    • 33846184752 scopus 로고    scopus 로고
    • Nanog and transcriptional networks in embryonic stem cell pluripotency.
    • Pan G, Thomson JA. Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res 2007, 17: 42-49.
    • (2007) Cell Res , vol.17 , pp. 42-49
    • Pan, G.1    Thomson, J.A.2
  • 106
    • 33845628507 scopus 로고    scopus 로고
    • A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal.
    • Pan G, Li J, Zhou Y, Zheng H, Pei D. A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J 2006, 20: 1730-1732.
    • (2006) FASEB J , vol.20 , pp. 1730-1732
    • Pan, G.1    Li, J.2    Zhou, Y.3    Zheng, H.4    Pei, D.5
  • 108
    • 48749122623 scopus 로고    scopus 로고
    • Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells.
    • Kopp JL, Ormsbee BD, Desler M, Rizzino A. Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells. Stem Cells (Dayton, Ohio) 2008, 26: 903-911.
    • (2008) Stem Cells (Dayton, Ohio) , vol.26 , pp. 903-911
    • Kopp, J.L.1    Ormsbee, B.D.2    Desler, M.3    Rizzino, A.4
  • 110
    • 0034028901 scopus 로고    scopus 로고
    • Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells.
    • Niwa H, Miyazaki J-I, Smith AG. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 2000, 24: 372-376.
    • (2000) Nat Genet , vol.24 , pp. 372-376
    • Niwa, H.1    Miyazaki, J.-I.2    Smith, A.G.3
  • 111
    • 79958263080 scopus 로고    scopus 로고
    • Pluripotency factors in embryonic stem cells regulate differentiation into germ layers.
    • Thomson M, Liu SJ, Zou L-N, Smith Z, Meissner A, Ramanathan S. Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell 2011, 145: 875-889.
    • (2011) Cell , vol.145 , pp. 875-889
    • Thomson, M.1    Liu, S.J.2    Zou, L.-N.3    Smith, Z.4    Meissner, A.5    Ramanathan, S.6
  • 112
  • 113
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells.
    • Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R
    • Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science (New York, N.Y.) 2007, 318: 1917-1920.
    • (2007) Science (New York, N.Y.) , vol.318 , pp. 1917-1920
    • Yu, J.1
  • 114
    • 84856007232 scopus 로고    scopus 로고
    • The promise of induced pluripotent stem cells in research and therapy.
    • Robinton DA, Daley GQ. The promise of induced pluripotent stem cells in research and therapy. Nature 2012, 481: 295-305.
    • (2012) Nature , vol.481 , pp. 295-305
    • Robinton, D.A.1    Daley, G.Q.2
  • 117
    • 69349089552 scopus 로고    scopus 로고
    • Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells.
    • Eminli S, Foudi A, Stadtfeld M, Maherali N, Ahfeldt T, Mostoslavsky G, Hock H, Hochedlinger K. Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat Genet 2009, 41: 968-976.
    • (2009) Nat Genet , vol.41 , pp. 968-976
    • Eminli, S.1    Foudi, A.2    Stadtfeld, M.3    Maherali, N.4    Ahfeldt, T.5    Mostoslavsky, G.6    Hock, H.7    Hochedlinger, K.8
  • 122
    • 37549008674 scopus 로고    scopus 로고
    • c-Myc is dispensable for direct reprogramming of mouse fibroblasts.
    • Wernig M, Meissner A, Cassady JP, Jaenisch R. c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell 2008, 2: 10-12.
    • (2008) Cell Stem Cell , vol.2 , pp. 10-12
    • Wernig, M.1    Meissner, A.2    Cassady, J.P.3    Jaenisch, R.4
  • 124
    • 77957309799 scopus 로고    scopus 로고
    • Rapid and efficient reprogramming of human amnion-derived cells into pluripotency by three factors OCT4/SOX2/NANOG.
    • Zhao H-X, Li Y, Jin H-F, Xie L, Liu C, Jiang F, Luo Y-N, Yin G-W, Li Y, Wang J, et al. Rapid and efficient reprogramming of human amnion-derived cells into pluripotency by three factors OCT4/SOX2/NANOG. Differentiation 2010, 80: 123-129.
    • (2010) Differentiation , vol.80 , pp. 123-129
    • Zhao, H.-X.1    Li, Y.2    Jin, H.-F.3    Xie, L.4    Liu, C.5    Jiang, F.6    Luo, Y.-N.7    Yin, G.-W.8    Li, Y.9    Wang, J.10
  • 126
    • 78650915547 scopus 로고    scopus 로고
    • Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules.
    • Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, Ge J, Liu C, Zhang W, Zhang X, et al. Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res 2011, 21: 196-204.
    • (2011) Cell Res , vol.21 , pp. 196-204
    • Li, Y.1    Zhang, Q.2    Yin, X.3    Yang, W.4    Du, Y.5    Hou, P.6    Ge, J.7    Liu, C.8    Zhang, W.9    Zhang, X.10
  • 127
    • 62949220231 scopus 로고    scopus 로고
    • Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells.
    • Feng B, Ng J-H, Heng J-CD, Ng H-H. Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell 2009, 4: 301-312.
    • (2009) Cell Stem Cell , vol.4 , pp. 301-312
    • Feng, B.1    Ng, J.-H.2    Heng, J.-C.3    Ng, H.-H.4
  • 128
    • 67650095196 scopus 로고    scopus 로고
    • Elite and stochastic models for induced pluripotent stem cell generation.
    • Yamanaka S. Elite and stochastic models for induced pluripotent stem cell generation. Nature 2009, 460: 49-52.
    • (2009) Nature , vol.460 , pp. 49-52
    • Yamanaka, S.1
  • 131
    • 80555131195 scopus 로고    scopus 로고
    • Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis.
    • Tong M, Lv Z, Liu L, Zhu H, Zheng Q-Y, Zhao X-Y, Li W, Wu Y-B, Zhang H-J, Wu H-J, et al. Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis. Cell Res 2011, 21: 1634-1637.
    • (2011) Cell Res , vol.21 , pp. 1634-1637
    • Tong, M.1    Lv, Z.2    Liu, L.3    Zhu, H.4    Zheng, Q.-Y.5    Zhao, X.-Y.6    Li, W.7    Wu, Y.-B.8    Zhang, H.-J.9    Wu, H.-J.10
  • 134
    • 79952534749 scopus 로고    scopus 로고
    • iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation.
    • Li W, Zhao X-Y, Wan H-F, Zhang Y, Liu L, Lv Z, Wang X-J, Wang L. iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation. Cell Res 2011, 21: 550-553.
    • (2011) Cell Res , vol.21 , pp. 550-553
    • Li, W.1    Zhao, X.-Y.2    Wan, H.-F.3    Zhang, Y.4    Liu, L.5    Lv, Z.6    Wang, X.-J.7    Wang, L.8
  • 135
    • 70450285340 scopus 로고    scopus 로고
    • Technical challenges in using human induced pluripotent stem cells to model disease.
    • Saha K, Jaenisch R. Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell 2009, 5: 584-595.
    • (2009) Cell Stem Cell , vol.5 , pp. 584-595
    • Saha, K.1    Jaenisch, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.