메뉴 건너뛰기




Volumn 124, Issue 22, 1997, Pages 4467-4480

Cellular interpretation of multiple TGF-β signals: Intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

Author keywords

Activin; BMP; Mesoderm; Smad; TGF ; Vg1; Xenopus

Indexed keywords

ACTIVIN; BONE MORPHOGENETIC PROTEIN; PROTEIN; RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 0030663881     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (228)

References (64)
  • 1
    • 0029829230 scopus 로고    scopus 로고
    • A novel mesoderm inducer. Made functions in the activin signal iransduction pathway
    • Baker, J. C. and Harland, R. M. (1996). A novel mesoderm inducer. Made functions in the activin signal iransduction pathway, Genes Dev. 10, 1884-1889.
    • (1996) Genes Dev. , vol.10 , pp. 1884-1889
    • Baker, J.C.1    Harland, R.M.2
  • 2
    • 0028901204 scopus 로고
    • Anterior neuroectoderm is progressively induced during gasirulation: The role of the Xenopus homeobox gene orthodenticle
    • Blitz, I. L. and Cho, K. W. Y. (1995). Anterior neuroectoderm is progressively induced during gasirulation: the role of the Xenopus homeobox gene orthodenticle. Development 121, 993-1004.
    • (1995) Development , vol.121 , pp. 993-1004
    • Blitz, I.L.1    Cho, K.W.Y.2
  • 4
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptinal partner for MAD proteins in TGF-β singalling
    • Chen, X., Rubuck, M. J. and Whitman, M. (1996). A transcriptinal partner for MAD proteins in TGF-β singalling. Nature 383, 691-696.
    • (1996) Nature , vol.383 , pp. 691-696
    • Chen, X.1    Rubuck, M.J.2    Whitman, M.3
  • 6
    • 0026342562 scopus 로고
    • Molecular nature of Spemann's organizer: The role of the Xenopus homeobox gene goosecoid
    • Cho, K. W. Y., Blumberg, G., Steinbeisser, H. and De Robertis, E. M. (1991). Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. Cell 67, 1111-1120.
    • (1991) Cell , vol.67 , pp. 1111-1120
    • Cho, K.W.Y.1    Blumberg, G.2    Steinbeisser, H.3    De Robertis, E.M.4
  • 7
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-ehloroform extraction
    • Chomzynski, P. and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-ehloroform extraction. Analyt. Biochem. 162, 156-159.
    • (1987) Analyt. Biochem. , vol.162 , pp. 156-159
    • Chomzynski, P.1    Sacchi, N.2
  • 8
    • 0026717301 scopus 로고
    • Bone morphogenetic protein 4: A ventralizing factor in early Xenopus development
    • Dale, L., Howes, G., Price, B. M. J. and Smith, J. C. (1992) Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development. Development 115, 573-585.
    • (1992) Development , vol.115 , pp. 573-585
    • Dale, L.1    Howes, G.2    Price, B.M.J.3    Smith, J.C.4
  • 9
    • 0027377563 scopus 로고
    • Secretion and mesoderm-inducing activity of the TGF-beta-related domain of Xenopus Vgl
    • Dale, L., Matthews, G. and Colman, A. (1993). Secretion and mesoderm-inducing activity of the TGF-beta-related domain of Xenopus Vgl. EMKO J. 12, 4471-4480.
    • (1993) EMKO J. , vol.12 , pp. 4471-4480
    • Dale, L.1    Matthews, G.2    Colman, A.3
  • 11
    • 0030265714 scopus 로고    scopus 로고
    • The Mad way to do it
    • Derynck, R. and Zhang, Y. (1996). The Mad way to do it. Curr. Biol. 6, 1226-1229.
    • (1996) Curr. Biol. , vol.6 , pp. 1226-1229
    • Derynck, R.1    Zhang, Y.2
  • 12
    • 0023124097 scopus 로고
    • Firefly, lucifcrase gene: Structure and expression in mammalian cells
    • de Wet., J. R., Wood, K. V., DeLuca, M., Helinski, D. R. and Subramani, S. (1987). Firefly, lucifcrase gene: Structure and expression in mammalian cells. Mol. Cell Rial 7, 725-737.
    • (1987) Mol. Cell Rial , vol.7 , pp. 725-737
    • De Wet, J.R.1    Wood, K.V.2    DeLuca, M.3    Helinski, D.R.4    Subramani, S.5
  • 14
    • 0028110497 scopus 로고
    • On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo
    • Fainsod, A., Steinbeisser, H. and De Robertis, E. M. (1994). On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo. EMRO J 13, 5015-5025.
    • (1994) EMRO J , vol.13 , pp. 5015-5025
    • Fainsod, A.1    Steinbeisser, H.2    De Robertis, E.M.3
  • 15
    • 0029562615 scopus 로고
    • Antagonizing the Spemann orgunizer: Role of the homeobox gene Xvent-1
    • Gawantka, V., Delius, H., Hirschfeld, K., Blumenstock, C., Nihers, C. (1995). Antagonizing the Spemann orgunizer: role of the homeobox gene Xvent-1 EMBO J. 14, 6268-6279.
    • (1995) EMBO J. , vol.14 , pp. 6268-6279
    • Gawantka, V.1    Delius, H.2    Hirschfeld, K.3    Blumenstock, C.4    Nihers, C.5
  • 16
    • 0028170038 scopus 로고
    • Studies with a Xenopus BMP receptor suggest hat ventral mesoderm-inducing signals override dorsal signals in vivo
    • Craff, J., Thies, R. S., Song, J. J., Celeste, A. I. and Melton, D. A. (1994) Studies with a Xenopus BMP receptor suggest (hat ventral mesoderm-inducing signals override dorsal signals in vivo. Cell 79, 169-179.
    • (1994) Cell , vol.79 , pp. 169-179
    • Craff, J.1    Thies, R.S.2    Song, J.J.3    Celeste, A.I.4    Melton, D.A.5
  • 17
    • 0029940972 scopus 로고    scopus 로고
    • Xenopus mad proteins transduce distinct suhsels of signals for the TGFβ supertamily
    • Graff, J. M., Bansal, A. and Melton, D. A. (1996). Xenopus mad proteins transduce distinct suhsels of signals for the TGFβ supertamily. Cell 85, 479-487.
    • (1996) Cell , vol.85 , pp. 479-487
    • Graff, J.M.1    Bansal, A.2    Melton, D.A.3
  • 18
    • 0025166072 scopus 로고
    • Graded changes in dose of a Xenopus activin A homologue elicit slepwise transitions in embryonic cell fate
    • Green, J. B. and Smith, J. C. (1990). Graded changes in dose of a Xenopus activin A homologue elicit slepwise transitions in embryonic cell fate Nature 347, 391-394.
    • (1990) Nature , vol.347 , pp. 391-394
    • Green, J.B.1    Smith, J.C.2
  • 20
    • 0029737070 scopus 로고    scopus 로고
    • Bone niorphogenetic proteins: Multifunctinal regulators of vertebrate development
    • Hogan, B. L. (1996). Bone niorphogenetic proteins: multifunctinal regulators of vertebrate development, Genes Dev. 10, 1580-1594.
    • (1996) Genes Dev. , vol.10 , pp. 1580-1594
    • Hogan, B.L.1
  • 22
    • 0023024991 scopus 로고
    • Biosynthesis of protease nexin-1
    • Howard, E. W., and knauer. D. J. (1986). Biosynthesis of protease nexin-1. J. Biol. Chem. 261, 14184-14190.
    • (1986) J. Biol. Chem. , vol.261 , pp. 14184-14190
    • Howard, E.W.1    Knauer, D.J.2
  • 23
    • 13344282101 scopus 로고    scopus 로고
    • Bone niorphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos
    • Jones, C. M., Dale, L., Hogan, B. L. M., Wright, C. V. E. and Smith, J. C. (1996). Bone niorphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos. Development 122, 1545-1554.
    • (1996) Development , vol.122 , pp. 1545-1554
    • Jones, C.M.1    Dale, L.2    Hogan, B.L.M.3    Wright, C.V.E.4    Smith, J.C.5
  • 24
    • 0028787260 scopus 로고
    • Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation
    • Jones, C. M., Kuehn, M. R., Hogan, B. L., Smith, J. C. and Wright, C. V. (1995). Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development 121, 3651-62.
    • (1995) Development , vol.121 , pp. 3651-3662
    • Jones, C.M.1    Kuehn, M.R.2    Hogan, B.L.3    Smith, J.C.4    Wright, C.V.5
  • 25
    • 0026680530 scopus 로고
    • DVR-4 (bone niorphogenetic protein-4) as a posteriorventralizing factor in Xenopus mesoderm induction
    • Jones, C. M., Lyons, K. M., Lapan, P. M., Wright, C. V. E. and Hogan, B. L. M. (1992). DVR-4 (bone niorphogenetic protein-4) as a posteriorventralizing factor in Xenopus mesoderm induction. Development 115, 639-647.
    • (1992) Development , vol.115 , pp. 639-647
    • Jones, C.M.1    Lyons, K.M.2    Lapan, P.M.3    Wright, C.V.E.4    Hogan, B.L.M.5
  • 26
    • 0029001002 scopus 로고
    • Induction of dorsal mesoderm by soluble. mature Vgl protein
    • Kessler, D. S. and Melton, D. A. (1995). Induction of dorsal mesoderm by soluble. mature Vgl protein. Development 121, 2155-64.
    • (1995) Development , vol.121 , pp. 2155-2164
    • Kessler, D.S.1    Melton, D.A.2
  • 27
    • 0030872367 scopus 로고    scopus 로고
    • Drosophila MAD hinds to DMA and directly mediates activation of vestigial by decapentaplcgic
    • Kim, J. Johnson, K. Chen, HJ, Carroll, S. Laughon, A. (1997) Drosophila MAD hinds to DMA and directly mediates activation of vestigial by decapentaplcgic. Nature 388, 304-308.
    • (1997) Nature , vol.388 , pp. 304-308
    • Kim, J.1    Johnson, K.2    Chen, H.J.3    Carroll, S.4    Laughon, A.5
  • 28
    • 0021770860 scopus 로고
    • Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs
    • Krieg, P. A. and Melton, D. A. (1984). Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs. Nucl. Acid Res. 12, 7057-7070.
    • (1984) Nucl. Acid Res. , vol.12 , pp. 7057-7070
    • Krieg, P.A.1    Melton, D.A.2
  • 29
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMADproteins in TGK-β signalling pathways
    • Lagna, G., Hata, A., Henimati-Brivanlou, A. and Massague, .J. (1996). Partnership between DPC4 and SMADproteins in TGK-β signalling pathways. Nature 383, 832-836.
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Henimati-Brivanlou, A.3    Massague, J.4
  • 31
    • 0029931509 scopus 로고    scopus 로고
    • A human mad protein acting as a BMP-regulated transcriptional activator
    • Liu, F., Hata, A., Baker, J. C., Doody, J., Carcamo, J., Harland, R. M. and Massague, J. (1996). A human mad protein acting as a BMP-regulated transcriptional activator. Nature 381, 620-623.
    • (1996) Nature , vol.381 , pp. 620-623
    • Liu, F.1    Hata, A.2    Baker, J.C.3    Doody, J.4    Carcamo, J.5    Harland, R.M.6    Massague, J.7
  • 32
    • 0030300115 scopus 로고    scopus 로고
    • MADR2 is a substrate of the TGHβ receptor and its phosphorylation is required for nuclear accumulation and signaling
    • Macias-Silva, M., Abdollah, S., Hoodless, P. A., Pirone, R., Attisano, L. and Wrana, J. L. (1996). MADR2 is a substrate of the TGHβ receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87, 1215-1224.
    • (1996) Cell , vol.87 , pp. 1215-1224
    • Macias-Silva, M.1    Abdollah, S.2    Hoodless, P.A.3    Pirone, R.4    Attisano, L.5    Wrana, J.L.6
  • 33
    • 0030604542 scopus 로고    scopus 로고
    • TGFβ signaling: Receptors, transducers, and mad proteins
    • Massague, J. (1996). TGFβ signaling: receptors, transducers, and mad proteins. Cell 85, 947-950.
    • (1996) Cell , vol.85 , pp. 947-950
    • Massague, J.1
  • 34
    • 0029894568 scopus 로고    scopus 로고
    • Direct and long-range action of a DPP morphogen gradient
    • Nellen, D., Burke, R., Struhl, G. and Basier, K. (1996) Direct and long-range action of a DPP morphogen gradient. Cell 85, 357-368.
    • (1996) Cell , vol.85 , pp. 357-368
    • Nellen, D.1    Burke, R.2    Struhl, G.3    Basier, K.4
  • 35
    • 0030018425 scopus 로고    scopus 로고
    • Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β-responsive cells
    • Newfcld, S. J., Chartoff, E. H., Graff, J. M., Lemton, D. A. and Gelbcrt, W. M. (1996). Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β-responsive cells. Development 122, 2099-2108.
    • (1996) Development , vol.122 , pp. 2099-2108
    • Newfcld, S.J.1    Chartoff, E.H.2    Graff, J.M.3    Lemton, D.A.4    Gelbcrt, W.M.5
  • 37
    • 0026986670 scopus 로고
    • Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos
    • Nishimatsu S., Suzuki, A., Shoda, A., Murakami, K. and Ueno, N. (1992) Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos. Bioch. Biophys. Res. Comm. 186, 1487-1495.
    • (1992) Bioch. Biophys. Res. Comm. , vol.186 , pp. 1487-1495
    • Nishimatsu, S.1    Suzuki, A.2    Shoda, A.3    Murakami, K.4    Ueno, N.5
  • 38
    • 0029843358 scopus 로고    scopus 로고
    • The Xvein-2 homeobox gene is part of the BMP-4 signallingpathway controling dorsovental patterning of Xenopus mesoderm
    • Onichtchouk, D., Gavtantka, V., Dosen R., Delius, H., Hirschfeld., Blumenstock, C. and Niehrs, C. (1996). The Xvein-2 homeobox gene is part of the BMP-4 signallingpathway controling dorsovental patterning of Xenopus mesoderm. Development 122, 3045-3053.
    • (1996) Development , vol.122 , pp. 3045-3053
    • Onichtchouk, D.1    Gavtantka, V.2    Dosen, R.3    Delius, H.4    Hirschfeld5    Blumenstock, C.6    Niehrs, C.7
  • 39
    • 0030598867 scopus 로고    scopus 로고
    • Dorsovental patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4
    • Piccolo, S., Sasai, Y., Lu, B. and De Robertis, E. M. (1996) Dorsovental patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell 86, 589-598.
    • (1996) Cell , vol.86 , pp. 589-598
    • Piccolo, S.1    Sasai, Y.2    Lu, B.3    De Robertis, E.M.4
  • 40
    • 0028893294 scopus 로고
    • Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophilu
    • Raftery, L. A., Twombly, V., Wharton, K. and Gelbert, W. M. (1995) Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophilu. Genetics 139, 241-254.
    • (1995) Genetics , vol.139 , pp. 241-254
    • Raftery, L.A.1    Twombly, V.2    Wharton, K.3    Gelbert, W.M.4
  • 42
    • 0030058914 scopus 로고    scopus 로고
    • Caenorhahditis elegans gene sma-2 and sma-3 and sma-4 dehne a conserved family of transforming growth factor b pathway components
    • Savage C., Das, P., Kinelli, A., Townsend, S., Sun, C., Baird, S. and Padgett. R. (1996). Caenorhahditis elegans gene sma-2 and sma-3 and sma-4 dehne a conserved family of transforming growth factor b pathway components. Proc. Natl. Acad. Sci. USA 93, 7790-9974.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7790-9974
    • Savage, C.1    Das, P.2    Kinelli, A.3    Townsend, S.4    Sun, C.5    Baird, S.6    Padgett, R.7
  • 43
    • 0028940853 scopus 로고
    • Genetic characterization and cloning of Mothers against dpp. a gene required for decapemaplegic function in Drosophila melanogaster
    • Sekelsky, J. J., Newfeld, S. J., Raftery, L. A., Chartoff, E. H. and Gelbert, W. M. (1995). Genetic characterization and cloning of Mothers against dpp. a gene required for decapemaplegic function in Drosophila melanogaster. Genetics 139, 1347-1358.
    • (1995) Genetics , vol.139 , pp. 1347-1358
    • Sekelsky, J.J.1    Newfeld, S.J.2    Raftery, L.A.3    Chartoff, E.H.4    Gelbert, W.M.5
  • 44
    • 0029013039 scopus 로고
    • Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo
    • Schmidt, J. K., Suzuki, A., Ueno, N. and Kimelman, D. (1995) Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo. Dev. Biol. 169, 37-50.
    • (1995) Dev. Biol. , vol.169 , pp. 37-50
    • Schmidt, J.K.1    Suzuki, A.2    Ueno, N.3    Kimelman, D.4
  • 45
    • 0030837455 scopus 로고    scopus 로고
    • A structural basis for mutational inactivation of the tumor suppressor Smad4
    • Shi, Y., Hata, A., Lo, R. S., Massague and Pavletich, N. P. (1997) A structural basis for mutational inactivation of the tumor suppressor Smad4. Nature 388, 87-93.
    • (1997) Nature , vol.388 , pp. 87-93
    • Shi, Y.1    Hata, A.2    Lo, R.S.3    Massague4    Pavletich, N.P.5
  • 46
    • 0028874544 scopus 로고
    • Mesoderm-inuucing factors and mesodermal patterning
    • Smith, J. C. (1995). Mesoderm-inuucing factors and mesodermal patterning. Curr. Opin. Cell Biol. 1, 856-61.
    • (1995) Curr. Opin. Cell Biol. , vol.1 , pp. 856-861
    • Smith, J.C.1
  • 47
    • 0029049830 scopus 로고
    • A nodal-related gene defines a physical and functional domain within the Spemann organizer
    • Smith, W. C., McKendry, R., Ribisi, S. and Harland, R. M. (1995). A nodal-related gene defines a physical and functional domain within the Spemann organizer. Cell 82, 37-46.
    • (1995) Cell , vol.82 , pp. 37-46
    • Smith, W.C.1    McKendry, R.2    Ribisi, S.3    Harland, R.M.4
  • 48
    • 1842283528 scopus 로고
    • The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: A loss-of-function study using antisense RNA
    • Steinbeisscr, H. Fainsod, A., Niehrs, C., Sasai, Y. and De Rohertis, E. M. (1995). The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA. HMKO J. 14, 230-243.
    • (1995) HMKO J. , vol.14 , pp. 230-243
    • Steinbeisscr, H.1    Fainsod, A.2    Niehrs, C.3    Sasai, Y.4    De Rohertis, E.M.5
  • 49
    • 0027548647 scopus 로고
    • Differential expression of Xenopous BMPs in early embryos and tissues
    • Suzuki, A., Nishimatsu, S., Murakami, K. and Ueno, N. (1993). Differential expression of Xenopous BMPs in early embryos and tissues, Zool. Sci. 10, 175-178.
    • (1993) Zool. Sci. , vol.10 , pp. 175-178
    • Suzuki, A.1    Nishimatsu, S.2    Murakami, K.3    Ueno, N.4
  • 50
    • 0028091791 scopus 로고
    • A truncated hone morphogcnetic prolein receptor affects dorsal-ventral patterning in the early Xenopiis embryo
    • Suzuki, A., Thies, R. S., Yamaji, N., Song, J. J., Wozney, J. M., Murakami, K. and Ueno, N. (1994). A truncated hone morphogcnetic prolein receptor affects dorsal-ventral patterning in the early Xenopiis embryo. Proc. Natl. Acad. Sci. USA 91, 10255-10259.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10255-10259
    • Suzuki, A.1    Thies, R.S.2    Yamaji, N.3    Song, J.J.4    Wozney, J.M.5    Murakami, K.6    Ueno, N.7
  • 52
    • 0029834231 scopus 로고    scopus 로고
    • Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor
    • Thomsen, G. H. (1996). Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor. Development 122, 2359-2366.
    • (1996) Development , vol.122 , pp. 2359-2366
    • Thomsen, G.H.1
  • 53
    • 0027272511 scopus 로고
    • Processed Vgl protein is an axial inesoderm inducer in Xenopus
    • Thomsen, G. and Melton, D. A. (1993). Processed Vgl protein is an axial inesoderm inducer in Xenopus. Cell 74, 433-441.
    • (1993) Cell , vol.74 , pp. 433-441
    • Thomsen, G.1    Melton, D.A.2
  • 54
    • 0025016517 scopus 로고
    • Activms are expressed early in Xenopus emhryogenesis and can induce axial mesoderm and anterior structures
    • Thomsen, G., Woolf, T., Whitman, M., Sokol, S., Vaughan, J., Vale, W. and Melton, D. A. (1990). Activms are expressed early in Xenopus emhryogenesis and can induce axial mesoderm and anterior structures, Cell 63, 485-493.
    • (1990) Cell , vol.63 , pp. 485-493
    • Thomsen, G.1    Woolf, T.2    Whitman, M.3    Sokol, S.4    Vaughan, J.5    Vale, W.6    Melton, D.A.7
  • 55
    • 0029585862 scopus 로고
    • Molecular mechanisms of Spemann's organizer formation: Conserved growth factor synergy between Xenopus and mouse
    • Watabe, T., Kim, S., Candia, A., Rothhachcr, U., Hashimoto, C., Inoue, K. and Cho K. W. Y. (1995). Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. Genes Dev. 9, 3038-3050.
    • (1995) Genes Dev. , vol.9 , pp. 3038-3050
    • Watabe, T.1    Kim, S.2    Candia, A.3    Rothhachcr, U.4    Hashimoto, C.5    Inoue, K.6    Cho, K.W.Y.7
  • 56
    • 0028170237 scopus 로고
    • TGF-β related genes in development
    • Wall, N. A. and Hogan, B. L. (1994). TGF-β related genes in development. Curr. Opin. Genet. Dev. 4. 517-522.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 517-522
    • Wall, N.A.1    Hogan, B.L.2
  • 57
    • 0029022221 scopus 로고
    • GS domain mutations that constitutively activate T beta R-I. The downstream signaling component in the TGF-βeta receptor complex
    • Wicser, R., Wrana, J. L., and Massaguc, J. (1995). GS domain mutations that constitutively activate T beta R-I. The downstream signaling component in the TGF-βeta receptor complex. KMRO J. 14, 2199-2208.
    • (1995) KMRO J. , vol.14 , pp. 2199-2208
    • Wicser, R.1    Wrana, J.L.2    Massaguc, J.3
  • 59
    • 0030974042 scopus 로고    scopus 로고
    • Homomeric and heteromeric interactions arc required for signaling activity and functional cooperativity of Smad-3 and -4
    • Wu, R. -Y., Zhang, Y., Feng, X. -H. and Derynck, R. (1997) Homomeric and heteromeric interactions arc required for signaling activity and functional cooperativity of Smad-3 and -4. Mol Cell. Biol. 17, 2521-2528.
    • (1997) Mol Cell. Biol. , vol.17 , pp. 2521-2528
    • Wu, R.Y.1    Zhang, Y.2    Feng, X.H.3    Derynck, R.4
  • 61
    • 0029833909 scopus 로고    scopus 로고
    • Mammalian Dwarfins are phosphorylaled in response to transforming growth factor-β and are implicated in control of cell growth
    • Yingling, J. M., Das, P., Savage, C., Zhang, M., Padgetts, R. and Wang, X. F. (1996). Mammalian Dwarfins are phosphorylaled in response to transforming growth factor-β and are implicated in control of cell growth. Proc. Natl. Acad. Sci. USA 93, 8940-8944.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 8940-8944
    • Yingling, J.M.1    Das, P.2    Savage, C.3    Zhang, M.4    Padgetts, R.5    Wang, X.F.6
  • 62
    • 0029786212 scopus 로고    scopus 로고
    • Receptor-associated Mad homologues synergize as effectors of the TGF-β response
    • Zhang, Y., Keng, X. -H., Wu, R. -Y. and Derynk, R. (1996). Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383, 168-172.
    • (1996) Nature , vol.383 , pp. 168-172
    • Zhang, Y.1    Keng, X.H.2    Wu, R.Y.3    Derynk, R.4
  • 63
    • 0031128153 scopus 로고    scopus 로고
    • The tumor suppressor Smad 4/DPC 4 as a central mediator of Smad function
    • Zhang, Y., Musci, T. and Derynck, R. (1997) The tumor suppressor Smad 4/DPC 4 as a central mediator of Smad function. Current Biol. 7, 270-276.
    • (1997) Current Biol. , vol.7 , pp. 270-276
    • Zhang, Y.1    Musci, T.2    Derynck, R.3
  • 64
    • 0030598829 scopus 로고    scopus 로고
    • The Spemann organizer signal noggin hinds and inactivates hone morphogenetic protein 4
    • Zimmerman, L. B., De Jesus-Escohar, J. M. and Harland, R. M. (1996) The Spemann organizer signal noggin hinds and inactivates hone morphogenetic protein 4. Cell 86, 599-606.
    • (1996) Cell , vol.86 , pp. 599-606
    • Zimmerman, L.B.1    De Jesus-Escohar, J.M.2    Harland, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.