Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa

Biochemical and Biophysical Research Communications

Volumn 425, Issue 1, 2012, Pages 89-93

  Shoji, Masaki ^a   Tachibana, Masashi ^a   Katayama, Kazufumi ^a   Tomita, Kyoko ^a   Tsuzuki, Sayaka ^a   Sakurai, Fuminori ^a   Kawabata, Kenji ^a,b   Ishii, Ken J ^a,b   Akira, Shizuo ^a,c   Mizuguchi, Hiroyuki ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Adaptive immunity; Adenovirus vector; Gut mucosa; Innate immunity; Type I interferon; Vaccine

Indexed keywords

ADENOVIRUS VECTOR; INTERFERON; MESSENGER RNA; RETINAL DEHYDROGENASE; VIRUS VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; INTESTINE MUCOSA; LYMPHATIC DRAINAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VACCINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD8; CD8-POSITIVE T-LYMPHOCYTES; GENETIC VECTORS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; IMMUNITY, INNATE; INJECTIONS, INTRAMUSCULAR; INTERFERON TYPE I; INTESTINAL MUCOSA; INTESTINE, SMALL; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; RECEPTOR, INTERFERON ALPHA-BETA; SIGNAL TRANSDUCTION; TRETINOIN; VACCINATION; VACCINES, ADENOVIRUS;

ADENOVIRIDAE;

EID: 84865171595     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.07.056     Document Type: Article

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