Induction of type I interferon by adenovirus-encoded small RNAs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 40, 2010, Pages 17286-17291

  Yamaguchi, Tomoko ^a,b   Kawabata, Kenji ^a,b   Kouyama, Emi ^b   Ishii, Ken J ^a,b   Katayama, Kazufumi ^a   Suzuki, Takayuki ^a,b   Kurachi, Shinnosuke ^a,b   Sakurai, Fuminori ^a   Akira, Shizuo ^a   Mizuguchi, Hiroyuki ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

Author keywords

IFN promoter stimulator 1; Innate immune response; Virus associated RNA

Indexed keywords

ADENOVIRUS VECTOR; ALPHA INTERFERON; BETA INTERFERON; DNA DIRECTED RNA POLYMERASE III; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RNA;

ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; FIBROBLAST; INNATE IMMUNITY; INTERFERON PRODUCTION; PRIORITY JOURNAL; VIRUS RECOMBINANT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOVIRIDAE; ANIMALS; CYTOKINES; DENDRITIC CELLS; FIBROBLASTS; GENETIC VECTORS; IMMUNITY, INNATE; INTERFERON TYPE I; MICE; RNA; TRANSCRIPTIONAL ACTIVATION;

ADENOVIRIDAE; MIRIDAE;

EID: 78049275345     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1009823107     Document Type: Article

References (47)

1. Sakurai H, Kawabata K, Sakurai F, Nakagawa S, Mizuguchi H (2008) Innate immune response induced by gene delivery vectors. Int J Pharm 354:9-15.
2. Chen D, Murphy B, Sung R, Bromberg JS (2003) Adaptive and innate immune responses to gene transfer vectors: Role of cytokines and chemokines in vector function. Gene Ther 10:991-998.
3. Palmer DJ, Ng P (2005) Helper-dependent adenoviral vectors for gene therapy. Hum Gene Ther 16:1-16.
4. Yoneyama M, Fujita T (2010) Recognition of viral nucleic acids in innate immunity. Rev Med Virol 20:4-22.
5. Basner-Tschakarjan E, et al. (2006) Adenovirus efficiently transduces plasmacytoid dendritic cells resulting in TLR9-dependent maturation and IFN-alpha production. J Gene Med 8:1300-1306.
6. Yamaguchi T, et al. (2007) Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors. Hum Gene Ther 18:753-762.
7. Zhu J, Huang X, Yang Y (2007) Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways. J Virol 81:3170-3180.
8. Yoneyama M, et al. (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 5:730-737.
9. Yoneyama M, et al. (2005) Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol 175:2851-2858.
10. Andrejeva J, et al. (2004) The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci USA 101:17264-17269.
11. Kato H, et al. (2006) Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441:101-105.
12. Kato H, et al. (2005) Cell type-specific involvement of RIG-I in antiviral response. Immunity 23:19-28.
13. Hornung V, et al. (2006) 5?-Triphosphate RNA is the ligand for RIG-I. Science 314:994-997.
14. Cui S, et al. (2008) The C-terminal regulatory domain is the RNA 5′-triphosphate sensor of RIG-I. Mol Cell 29:169-179.
15. Nallagatla SR, et al. (2007) 5′-triphosphate-dependent activation of PKR by RNAs with short stem-loops. Science 318:1455-1458.
16. Kawai T, et al. (2005) IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6:981-988.
17. Muruve DA, et al. (2004) Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo. J Virol 78:5966-5972.
18. Mathews MB, Shenk T (1991) Adenovirus virus-associated RNA and translation control. J Virol 65:5657-5662.
19. Clarke PA, Mathews MB (1995) Interactions between the double-stranded RNA binding motif and RNA: Definition of the binding site for the interferon-induced protein kinase DAI (PKR) on adenovirus VA RNA. RNA 1:7-20.
20. Nayak R, Pintel DJ (2007) Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA. J Virol 81:11908-11916.
21. Wahid AM, Coventry VK, Conn GL (2008) Systematic deletion of the adenovirus-associated RNAI terminal stem reveals a surprisingly active RNA inhibitor of double-stranded RNA-activated protein kinase. J Biol Chem 283:17485-17493.
22. Lutz MB, et al. (1999) An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 223:77-92.
23. Rajan P, et al. (1995) A novel translational regulation function for the simian virus 40 large-T antigen gene. J Virol 69:785-795.
24. Hiscott J (2007) Triggering the innate antiviral response through IRF-3 activation. J Biol Chem 282:15325-15329.
25. Fredericksen BL, Keller BC, Fornek J, Katze MG, Gale M, Jr. (2008) Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1. J Virol 82:609-616.
26. Loo YM, et al. (2008) Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol 82:335-345.
27. Satoh T, et al. (2010) LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci USA 107:1512-1517.
28. Venkataraman T, et al. (2007) Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. J Immunol 178:6444-6455.
29. Yang P, et al. (2010) The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol 11:487-494.
30. Sakurai H, et al. (2008) Adenoviral expression of suppressor of cytokine signaling-1 reduces adenovirus vector-induced innate immune responses. J Immunol 180:4931-4938.
31. Koizumi N, et al. (2007) Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production. J Immunol 178:1767-1773.
32. Zhu J, Huang X, Yang Y (2007) Type I IFN signaling on both B and CD4 T cells is required for protective antibody response to adenovirus. J Immunol 178:3505-3510.
33. Fejer G, et al. (2008) Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo. PLoS Pathog 4:e1000208.
34. Muruve DA, et al. (2008) The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 452:103-107.
35. Bürckstümmer T, et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 10:266-272.
36. Takaoka A, et al. (2007) DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448:501-505.
37. Hornung V, et al. (2009) AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458:514-518.
38. Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458:509-513.
39. Ishii KJ, et al. (2008) TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 451:725-729.
40. Wang Z, et al. (2008) Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules. Proc Natl Acad Sci USA 105:5477-5482.
41. Rathinam VA, et al. (2010) The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol 11:395-402.
42. Samanta M, Iwakiri D, Kanda T, Imaizumi T, Takada K (2006) EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN. EMBO J 25:4207-4214.
43. Mizuguchi H, et al. (2001) A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob. Gene Ther 8:730-735.
44. Koizumi N, Mizuguchi H, Utoguchi N, Watanabe Y, Hayakawa T (2003) Generation of fiber-modified adenovirus vectors containing heterologous peptides in both the HI loop and C terminus of the fiber knob. J Gene Med 5:267-276.
45. Palmer D, Ng P (2003) Improved system for helper-dependent adenoviral vector production. Mol Ther 8:846-852.
46. Maizel JV, Jr., White DO, Scharff MD (1968) The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12. Virology 36:115-125.
47. Kumar H, et al. (2006) Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med 203:1795-1803.