Disruption of type-I IFN pathway ameliorates preservation damage in mouse orthotopic liver transplantation via HO-1 dependent mechanism

American Journal of Transplantation

Volumn 12, Issue 7, 2012, Pages 1730-1739

  Shen, X D ^a   Ke, B ^a   Ji, H ^a   Gao, F ^a   Freitas, M C S ^a   Chang, W W ^a   Lee, C ^a   Zhai, Y ^a   Busuttil, R W ^a   Kupiec Weglinski, Jerzy W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

HO 1; Ischemia reperfusion injury; Liver transplantation; Type I IFN

Indexed keywords

ALANINE AMINOTRANSFERASE; CASPASE 3; ENZYME; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HEMEOXYGENASE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON; INTERFERON RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE SILENCING; GRAFT SURVIVAL; INNATE IMMUNITY; LIVER TRANSPLANTATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; ORGAN PRESERVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SURVIVAL; SUZUKI REACTION;

ALANINE TRANSAMINASE; ANIMALS; HEME OXYGENASE-1; IN SITU NICK-END LABELING; INTERFERON TYPE I; LIVER TRANSPLANTATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84863187438     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2012.04021.x     Document Type: Article

References (32)

1. Wertheim JA, Petrowsky H, Saab S, Kupiec-Weglinski JW, Busuttil RW. Major challenges limiting liver transplantation in the United States. Am J Transplant 2011; 11: 1773-84.
2. Zhai Y, Shen XD, O'Connell R, et al. Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol 2004;173: 7115-7119. (Pubitemid 39628144)
3. Tsung A, Hoffman RA, Izuishi K, et al. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol 2005; 175: 7661-7668. (Pubitemid 41713466)
4. Wang L, Xu JB, Wu HS, et al. The relationship between activation of TLR4 and partial hepatic ischemia/reperfusion injury in mice. Hepatobiliary Pancreat Dis Int 2006; 5: 101-104.
5. Zhai Y, Busuttil RW, Kupiec-Weglinski JW. Liver ischemia and reperfusion injury: New insights into mechanisms of innate-adaptive immune-mediated tissue inflammation. Am J Transplant 2011; 11: 1563-1569.
6. Trinchieri G. Type I interferon: Friend or foe? J Exp Med 2010; 207: 2053-2063.
7. Zhai Y, Qiao B, Gao F, et al. Type-I, but not Type-II, interferon is critical in liver injury induced after ischemia and reperfusion. Hepatology 2008; 47: 199-206. (Pubitemid 351171057)
8. Shen XD, Gao F, Ke B, et al. Inflammatory responses in a new mouse model of prolonged hepatic cold ischemia followed by arterialized orthotopic liver transplantation. Liver Transpl 2005; 11: 1273-1281. (Pubitemid 41511943)
9. Shen XD, Ke B, Zhai Y, et al. Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model. Liver Transpl 2007; 13: 1435-1443. (Pubitemid 47629578)
10. Qian SG, Fung JJ, Demetris AV, Ildstad ST, Starzi TE. Orthotopic liver transplantation in the mouse. Transplantation 1991; 52: 562-564.
11. Ke B, Shen XD, Gao F, et al. Small interfering RNA targeting heme oxygenase-1 (HO-1) reinforces liver apoptosis induced by ischemia reperfusion injury in mice: HO-1 is necessary for cytoprotection. Hum Gene Ther 2009; 20: 1133-1142.
12. Soutschek J, Akinc A, Bramlage B, et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 2004; 432: 173-178. (Pubitemid 39545841)
13. Mullane KM, Kraemer R, Smith RB. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 1985; 4: 157-167. (Pubitemid 15241170)
14. Suzuki S, Toledo-Pereyra LH, Rodriguez FJ, Cejalvo D. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine. Transplantation 1993; 55: 1265-1272. (Pubitemid 23183235)
15. Uchida Y, Ke B, Freitas MC, et al. The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse. Hepatology 2010; 51: 1363-1372.
16. Katori M, Busuttil RW, Kupiec-Weglinski JW. Heme oxygenase-1 system in organ transplantation. Transplantation. 2002; 74: 905-912 (Pubitemid 35191234)
17. Kolls JK. Oxidative stress in sepsis: a redox redux. J Clin Invest 2006; 116: 860-863.
18. Freitas MC, Uchida Y, Lassman C, Danovitch GM, Busuttil RW, Kupiec-Weglinski JW. Type-I Interferon Pathway Mediates Renal Ischemia/Reperfusion Injury. Transplantation. 2011; 92: 131-138.
19. Zhai Y, Shen XD, Gao F, et al. CXCL10 regulates liver innate immune response against ischemia and reperfusion injury. Hepatology 2008; 47: 207-214. (Pubitemid 351171058)
20. Tsuchihashi S, Zhai Y, Qiao B, Busuttil RW, Kupiec-Weglinski JW. Heme oxygenase-1 mediated cytoprotection against liver ischemia and reperfusion injury: Inhibition of type-1 interferon signaling. Transplantation 2007; 83: 1628-1634. (Pubitemid 46987916)
21. Soares MP, Bach FH. Heme oxygenase-1 in organ transplantation. Front Biosci 2007; 12: 4932-4945.
22. Baan C, Peeters A, Lemos F, et al. Fundamental role for HO-1 in the self-protection of renal allografts. Am J Transplant 2004; 4: 811-818. (Pubitemid 38637582)
23. Geuken E, Buis CI, Visser DS, et al. Expression of heme oxygenase-1 in human livers before transplantation correlates with graft injury and function after transplantation. Am J Transplant. 2005; 5: 1875-1885. (Pubitemid 41039860)
24. Ke B, Shen XD, Tsuchihashi S, et al. Viral interleukin-10 gene transfer prevents liver ischemia-reperfusion injury: Toll-like receptor-4 and heme oxygenase-1 signaling in innate and adaptive immunity. Hum Gene Ther 2007; 18: 355-366. (Pubitemid 46709347)
25. Lee TS, Chau LY. Heme oxygenase-1 mediates the antiinflammatory effect of interleukin-10 in mice. Nat Med 2002; 8: 240-246.
26. Tzima S, Victoratos P, Kranidioti K, Alexiou M, Kollias G. Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-b production. J Exp Med 2009; 2006: 1167-1179.
27. Coito AJ, Buelow R, Shen XD, et al. Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury. Transplantation 2002; 74: 96-102. (Pubitemid 34779218)
28. Devey L, Ferenbach D, Mohr E, et al. Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism. Mol Ther 2009; 17: 65-72.
29. Thimmulappa RK, Lee H, Rangasamy T, et al. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest 2006; 116: 984-995.
30. Liu M, Grigoryev DN, Crow MT, et al. Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice. Kidney Int 2009; 76: 277-285.
31. Zaman MB, Leonard MO, Ryan EJ, et al. Lower expression of Nrf2 mRNA in older donor livers: A possible contributor to increased ischemia-reperfusion injury? Transplantation 2007; 84: 1272-1278. (Pubitemid 351339315)
32. Wang B, Cao W, Biswal S, Doré S. Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia. Stroke 2011; 42: 2605-2610.