CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling

Journal of Immunology

Volumn 185, Issue 3, 2010, Pages 1513-1521

  Lindsay, Ross W B ^a   Darrah, Patricia A ^a   Quinn, Kylie M ^a   Wille Reece, Ulrike ^a   Mattei, Lisa M ^b   Iwasaki, Akiko ^b   Kasturi, Sudhir P ^c   Pulendran, Bali ^c   Gall, Jason G D ^d   Spies, A Gregory ^e   Seder, Robert A ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY   (United States)

^d GENVEC INC   (United States)

^e Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; CD8 ANTIGEN; GLYCOPROTEIN P 15095; GREEN FLUORESCENT PROTEIN; INTERFERON; INTERLEUKIN 1; INTERLEUKIN 12; MYELOID DIFFERENTIATION FACTOR 88; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR 3; REPLICATION DEFECTIVE ADENOVIRUS 5; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; VIRUS VACCINE; VIRUS VECTOR; NLRC5 PROTEIN, MOUSE; OLIGODEOXYRIBONUCLEOTIDE; SIGNAL PEPTIDE;

ADENOVIRUS 5; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENETIC TRANSFECTION; IMMUNIZATION; INNATE IMMUNITY; LYMPH NODE; MOUSE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROTYPE; ANIMAL; ANTIGEN PRESENTATION; BIOSYNTHESIS; C57BL MOUSE; DEFECTIVE VIRUS; DENDRITIC CELL; GENETICS; HUMAN ADENOVIRUS; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; MOUSE MUTANT; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; VIRION; VIROLOGY;

ADENOVIRUSES, HUMAN; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD11C; CD8-POSITIVE T-LYMPHOCYTES; DEFECTIVE VIRUSES; DENDRITIC CELLS; IMMUNITY, INNATE; IMMUNOPHENOTYPING; INTERFERON TYPE I; INTERLEUKIN-12; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGODEOXYRIBONUCLEOTIDES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; VIRAL VACCINES; VIRION;

EID: 77956409681     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000338     Document Type: Article

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