Activated protein C has a protective effect against myocardial I/R injury by improvement of endothelial function and activation of AKT1

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Maehata, Yoshito ^a   Miyagawa, Shigeru ^a   Sawa, Yoshiki ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACTIVATED PROTEIN C; AKT1 PROTEIN; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY LIGATION; ECHOCARDIOGRAPHY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART FUNCTION; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE INJURY; HEART PROTECTION; LABORATORY DEVICE; LANGERDORFF APPARATUS; MALE; NONHUMAN; RAT; REPERFUSION INJURY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; ENZYME ACTIVATION; MALE; MYOCARDIAL ISCHEMIA; PROTEIN C; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 84865161330     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038738     Document Type: Article

References (33)

1. Liakopoulos OJ, Teucher N, Muhlfeld C, ((2006)) Prevention of TNFalpha-associated myocardial dysfunction resulting from cardiopulmonary bypass and cardioplegic arrest by glucocorticoid treatment. Eur J Cardiothorac Surg 30:: 263--270.
2. Aikawa R, Nawano M, Gu Y, ((2000)) Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt. Circulation 102:: 2873--2879.
3. Mosnier LO, Zlokovic BV, Griffin JH, ((2007)) The cytoprotective protein C pathway. Blood 109:: 3161--3172.
4. Griffin JH, Fernandez JA, Liu D, Cheng T, Guo H, et al. ((2004)) Activated protein C and ischemic stroke. Crit Care Med 32:: S247--253.
5. Mosnier LO, Griffin JH, ((2003)) Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor. Biochem J 373:: 65--70.
6. Nick JA, Coldren CD, Geraci MW, ((2004)) Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis. Blood 104:: 3878--3885.
7. Abraham E, ((2005)) Effects of recombinant human activated protein C in human models of endotoxin administration. Proc Am Thorac Soc 2:: 243--247.
8. Feistritzer C, Riewald M, ((2005)) Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood 105:: 3178--3184.
9. Yamauchi T, Sakurai M, Abe K, Takano H, Sawa Y, ((2006)) Neuroprotective effects of activated protein C through induction of insulin-like growth factor-1 (IGF-1), IGF-1 receptor, and its downstream signal phosphorylated serine-threonine kinase after spinal cord ischemia in rabbits. Stroke 37:: 1081--1086.
10. Guo H, Liu D, Gelbard H, ((2004)) Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron 41:: 563--572.
11. Yamanel L, Mas MR, Comert B, ((2005)) The effect of activated protein C on experimental acute necrotizing pancreatitis. Crit Care 9:: R184--190.
12. Mizutani A, Okajima K, Uchiba M, Noguchi T, ((2000)) Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood 95:: 3781--3787.
13. Finigan JH, Dudek SM, Singleton PA, ((2005)) Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation. J Biol Chem 280:: 17286--17293.
14. Jakson CJ, Xue M, Thompson P, ((2005)) Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing. Wound Repair Regen 13:: 284--294.
15. Fernandez JA, Vento AE, Jormalainen M, ((2006)) Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious hemodynamic effects. Cardiovasc Drugs Ther 20:: 113--121.
16. Morissette MR, Rosenzweig A, ((2005)) Targeting survival signaling in heart failure. Curr Opin Pharmacol 5:: 165--170.
17. Fukui S, Kitagawa-Sakakida S, Sawa Y, ((2008)) Therapeutic effect of midkine on cardiac remodeling in infarcted rat hearts. Ann Thirac Surg 85:: 562--70.
18. Ono M, Sawa Y, Ryugo M, ((2005)) BH4 peptide derivative from Bcl-xL attenuates ischemia/reperfusion injury thorough anti-apoptotic mechanism in rat hearts. Eur J Cardiothorac Surg 27:: 117--121.
19. Chang WL, Chung CH, Wu YC, Su MJ, ((2004)) The vascular and cardioprotective effects of liriodenine in ischemia-reperfusion injury via NO-dependent pathway. Nitric Oxide 11:: 307--315.
20. Nagoshi T, Matsui T, Aoyama T, ((2005)) PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest 115:: 2128--2138.
21. Isobe H, Okajima K, Uchiba M, ((2001)) Activated protein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxide. Circulation 104:: 1171--1175.
22. Favory R, Lancel S, Marechal X, Tissier S, Neviere R, ((2006)) Cardiovascular protective role for activated protein C during endotoxemia in rats. Intensive Care Med 32:: 899--905.
23. Pirat B, Muderrisoglu H, Unal MT, ((2007)) Recombinant human-activated protein C inhibits cardiomyocyte apoptosis in a rat model of myocardial ischemia-reperfusion. Coron Artery Dis 18:: 61--66.
24. Loubele ST, Spek A, Leenders P, van Oerle R, Aberson HL, et al. ((2009)) Activated Protein C Protects Against Myocardial Ischemia/Reperfusion Injury via Inhibition of Apoptosis and Inflammation. Arterioscler Tromb Vasc Biol 29: 29:: 1087--1092.
25. Uchiba M, Okajima K, Oike Y, ((2004)) Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo. Circ Res 95:: 34--41.
26. Joyce DE, Grinnell BW, ((2002)) Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-kappaB. Crit Care Med 30:: S288--293.
27. Cheng T, Liu D, Griffin JH, ((2003)) Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med 9:: 338--342.
28. Matsui T, Tao J, del Monte F, ((2001)) Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation 104:: 330--335.
29. Gao F, Gao E, Yue TL, ((2002)) Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation 105:: 1497--1502.
30. Gaudreault N, Perrin RM, Guo M, Clanton CP, Wu MH, et al. ((2008)) Counter regulatory effets of PKCβII and PKCδ on coronary endothelial permeability. Arterioscler Thromb Vas Biol 28:: 1527--1533.
31. Rubanyi GM, ((1993)) The role of endothelium in cardiovasucular homeostasis and diseases. J Cardiovasc Pharmacol 22:: S1--14.
32. Swaidi JA, Hamasaki S, Higano ST, ((2000)) Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction. Circulation 101:: 948--954.
33. Dossumbekova A, Berdyshev EV, Gorshkova I, ((2008)) Akt activates NOS3 and separately restores barrier integrity in H2O2-stressed human cardiac microvascular endothelium. Am J Physiol Heart Circ Physiol 295:: 2417--2426.