Recombinant human-activated protein C inhibits cardiomyocyte apoptosis in a rat model of myocardial ischemia-reperfusion

Coronary Artery Disease

Volumn 18, Issue 1, 2007, Pages 61-66

  Pirat, Bahar ^a,b   Muderrisoglu, Haldun ^a   Unal, Muge Tecder ^a   Ozdemir, Handan ^a   Yildirir, Aylin ^a   Yucel, Muammer ^a   Turkoglu, Suna ^a  

^a BASKENT UNIVERSITY   (Turkey)

^b Baskent Universitesi Ankara Hastanesi   (Turkey)

Author keywords

Activated protein C; Apoptosis; Ischemia reperfusion

Indexed keywords

C REACTIVE PROTEIN; CREATINE KINASE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DROTRECOGIN; RINGER LACTATE SOLUTION; TUMOR NECROSIS FACTOR ALPHA;

ANESTHESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; HEART HEMODYNAMICS; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MEAN ARTERIAL PRESSURE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SERUM;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; BLOOD PRESSURE; C-REACTIVE PROTEIN; CREATINE KINASE; DISEASE MODELS, ANIMAL; HEART RATE; HUMANS; IN SITU NICK-END LABELING; INFLAMMATION; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PROTEIN C; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33845755328     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/MCA.0b013e328010a44a     Document Type: Article

References (23)

1. Buja LM. Myocardial ischemia and reperfusion injury. Cardiovasc Pathol 2005; 14:170-175.
2. Dumont EA, Hofstra L, van Heerde WL, van den Eijnde S, Doevendans PA, DeMuinck E, et al. Cardiomyocyte death induced by myocardial ischemia and reperfusion: measurement with recombinant human annexin-V in a mouse model. Circulation 2000; 102:1564-1568.
3. Gottlieb RA, Burleson KO, Kloner RA, Babior BM, Engler RL. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest 1994; 94:1621-1628.
4. Zhao ZQ, Nakamura M, Wang NP, Wilcox JN, Shearer S, Ronson RS, et al. Reperfusion induces myocardial apoptotic cell death. Cardiovasc Res 2000; 45:651-660.
5. Nakamura T, Mizuno S, Matsumoto K, Sawa Y, Matsuda H. Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF. J Clin Invest 2000; 106:1511-1519.
6. Okamura T, Miura T, Takemura G, Fujiwara H, Iwamoto H, Kawamura S, et al. Effect of caspase inhibitors on myocardial infarct size and myocyte DNA fragmentation in the ischemia-reperfused rat heart. Cardiovasc Res 2000; 45:642-650.
7. Kobara M, Tatsumi T, Kambayashi D, Mano A, Yamanaka S, Shiraishi J, et al. Effects of ACE inhibition on myocardial apoptosis in an ischemia-reperfusion rat heart model. J Cardiovasc Pharmacol 2003; 41:880-889.
8. Esmon CT. The protein C pathway. Chest 2003; 124:26S-32S.
9. Dhainaut JF, Yan SB, Claessens YE. Protein C/activated protein C pathway: overview of clinical trial results in severe sepsis. Crit Care Med 2004; 32:S194-S201.
10. Cheng T, Liu D, Griffin JH, Fernandez JA, Castellino F, Rosen ED, et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med 2003; 9:338-342.
11. Schoots IG, Levi M, van Vliet AK, Maas AM, Roossink EH, van Gulik TM. Inhibition of coagulation and inflammation by activated protein C or antithrombin reduces intestinal ischemia/reperfusion injury in rats. Crit Care Med 2004; 32:1375-1383.
12. Walker MJ, Curtis MJ, Hearse DJ, Campbell RW, Janse MJ, Yellon DM, et al. The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion. Cardiovasc Res 1988; 22:447-455.
13. Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, et al. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation 2001; 103:1799-1805.
14. Mosnier LO, Griffin JH. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor. Biochem J 2003; 373:65-70.
15. Snow TR, Deal MT, Dickey DT, Esmon CT. Protein C activation following coronary artery occlusion in the in situ porcine heart. Circulation 1991;84:293-299.
16. Schmitt JP, Schroder J, Schunkert H, Birnbaum DE, Aebert H. Role of apoptosis in myocardial stunning after open heart surgery. Ann Thorac Surg 2002; 73:1229-1235.
17. Laugwitz KL, Moretti A, Weig HJ, Gillitzer A, Pinkernell K, Ott T, et al. Blocking caspase-activated apoptosis improves contractility in failing myocardium. Hum Gene Ther 2001; 12:2051-2063.
18. Vincent JL, Angus DC, Artigas A, Kalil A, Basson BR, Jamal HH, et al. Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med 2003; 31:834-840.
19. Meldrum DR. Tumor necrosis factor in the heart. Am J Physiol 1998; 274:R577-R595.
20. Grinnell BW, Joyce D. Recombinant human activated protein C: a system modulator of vascular function for treatment of severe sepsis. Crit Care Med 2001; 29:S53-S60; discussion S60-S51.
21. Wong SS, Sun NN, Hyde JD, Ruiz L, Meigs E, Herrin BR, et al. Drotrecogin alfa (activated) prevents smoke-induced increases in pulmonary microvascular permeability and proinflammatory cytokine IL-1beta in rats. Lung 2004; 182:319-330.
22. Mizutani A, Okajima K, Uchiba M, Noguchi T. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood 2000;95:3781-3787.
23. Kajstura J, Cheng W, Reiss K, Clark WA, Sonnenblick EH, Krajewski S, et al. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest. 1996; 74:86-107.