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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 17, 2012, Pages 5658-5662

N-Aryl pyrrolidinonyl oxadiazoles as potent mGluR5 positive allosteric modulators

(8) Packiarajan, Mathivanan a Mazza Ferreira, Christine G a Hong, Sang Phyo a White, Andrew D a Chandrasena, Gamini a Pu, Xiaosui a Brodbeck, Robbin M a Robichaud, Albert J a

a LUNDBECK RESEARCH USA (United States)

Author keywords

mGluR5 Positive allosteric modulators; N Aryl pyrrolidinonyl oxadiazoles; PAM to NAM switching

Indexed keywords

METABOTROPIC RECEPTOR 5; OXADIAZOLE DERIVATIVE;

ALLOSTERISM; ARTICLE; DRUG ACTIVITY; DRUG CLEARANCE; DRUG POTENCY; ENANTIOMER; IN VITRO STUDY; SENSITIVITY ANALYSIS;

ALLOSTERIC REGULATION; ANIMALS; CELL LINE; HUMANS; OXADIAZOLES; PYRROLIDINES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865113433 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.06.094 Document Type: Article

Times cited : (23)

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