Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma

American Journal of Gastroenterology

Volumn 106, Issue 1, 2011, Pages 81-92

  Yin, Jianhua ^a   Xie, Jiaxin ^a   Liu, Shijian ^a   Zhang, Hongwei ^a   Han, Lei ^a   Lu, Wenying ^a   Shen, Qiuxia ^a   Xu, Guozhang ^b   Dong, Hongjun ^b   Shen, Jie ^c   Zhang, Jun ^c   Han, Jiankang ^d   Wang, Lin ^e   Liu, Yan ^a   Wang, Fan ^a   Zhao, Jun ^a   Zhang, Qian ^a   Ni, Wu ^a   Wang, Hongyang ^a   Cao, Guangwen ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b NINGBO MUNICIPAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^c Municipal Center for Disease Control and Prevention of Soochow   (China)

^d Municipal Center for Disease Control and Prevention of Huzhou   (China)

^e District Center for Disease Control and Prevention of Yangpu   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B SURFACE ANTIGEN;

ADULT; AGE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; DISEASE ASSOCIATION; DNA SEQUENCE; FEMALE; GENDER; GENE MUTATION; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; UNINDEXED SEQUENCE;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ANALYSIS OF VARIANCE; CARCINOMA, HEPATOCELLULAR; CARRIER STATE; CHINA; COHORT STUDIES; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; FEMALE; GENOTYPE; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LINEAR MODELS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MUTATION; ODDS RATIO; PROGNOSIS; PROMOTER REGIONS, GENETIC; REFERENCE VALUES; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION; TIME FACTORS; VIRAL LOAD; YOUNG ADULT;

EID: 78650981205     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2010.399     Document Type: Article

References (55)

1. Lavanchy D. Worldwide epidemiology of HBV infection, disease burden, and vaccine prevention. J Clin Virol 2005; 34 (Suppl 1): S1-3.
2. Perz JF, Armstrong GL, Farrington LA et al. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol 2006; 45: 529-38.
3. Kay A, Zoulim F. Hepatitis B virus genetic variability and evolution. Virus Res 2007; 127: 164-76.
4. Yang HI, Lu SN, Liaw YF et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med 2002; 347: 168-74.
5. Chen CJ, Yang HI, Su J et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006; 295: 65-73.
6. Wu CF, Yu MW, Lin CL et al. Long-term tracking of hepatitis B viral load and the relationship with risk for hepatocellular carcinoma in men. Carcinogenesis 2008; 29: 106-12.
7. Schaefer S. Hepatitis B virus taxonomy and hepatitis B virus genotypes. World J Gastroenterol 2007; 13: 14-21.
8. Olinger CM, Jutavijittum P, Hubschen JM et al. Possible new hepatitis B virus genotype, southeast Asia. Emerg Infect Dis 2008; 14: 1777-80.
9. Tatematsu K, Tanaka Y, Kurbanov F et al. A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J. J Virol 2009; 83: 10538-47.
10. Cao GW. Clinical relevance and public health significance of hepatitis B virus genomic variations. World J Gastroenterol 2009; 15: 5761-9.
11. Chan HL, Tse CH, Mo F et al. High viral load and hepatitis B virus subgenotype ce are associated with increased risk of hepatocellular carcinoma. J Clin Oncol 2008; 26: 177-82.
12. Yu MW, Yeh SH, Chen PJ et al. Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men. J Natl Cancer Inst 2005; 97: 265-72.
13. Chan HL, Hui AY, Wong ML et al. Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma. Gut 2004; 53: 1494-8.
14. Kao JH, Chen PJ, Lai MY et al. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 2000; 118: 554-9.
15. Chan HL, Wong GL, Tse CH et al. Hepatitis B virus genotype C is associated with more severe liver fibrosis than genotype B. Clin Gastroenterol Hepatol 2009; 7: 1361-6.
16. Ni YH, Chang MH, Wang KJ et al. Clinical relevance of hepatitis B virus genotype in children with chronic infection and hepatocellular carcinoma. Gastroenterology 2004; 127: 1733-8.
17. Yin J, Zhang H, Li C et al. Role of hepatitis B virus genotype mixture, subgenotypes C2 and B2 on hepatocellular carcinoma: compared with chronic hepatitis B and asymptomatic carrier state in the same area. Carcinogenesis 2008; 29: 1685-91.
18. Erhardt A, Blondin D, Hauck K et al. Response to interferon alfa is hepatitis B virus genotype dependent: genotype A is more sensitive to interferon than genotype D. Gut 2005; 54: 1009-13.
19. Wai CT, Chu CJ, Hussain M et al. HBV genotype B is associated with better response to interferon therapy in HBeAg(+) chronic hepatitis than genotype C. Hepatology 2002; 36: 1425-30.
20. Kao JH, Chen PJ, Lai MY et al. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology 2003; 124: 327-34.
21. Yuen MF, Tanaka Y, Mizokami M et al. Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study. Carcinogenesis 2004; 25: 1593-8.
22. Chou YC, Yu MW, Wu CF et al. Temporal relationship between hepatitis B virus enhancer II/basal core promoter sequence variation and risk of hepatocellular carcinoma. Gut 2008; 57: 91-7.
23. Yuen MF, Tanaka Y, Shinkai N et al. Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels. Gut 2008; 57: 98-102.
24. Sung JJ, Tsui SK, Tse CH et al. Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus. J Virol 2008; 82: 3604-11.
25. Guo X, Jin Y, Qian G et al. Sequential accumulation of the mutations in core promoter of hepatitis B virus is associated with the development of hepatocellular carcinoma in Qidong, China. J Hepatol 2008; 49: 718-25.
26. Yang HI, Yeh SH, Chen PJ et al. Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. J Natl Cancer Inst 2008; 100: 1134-43.
27. Dong Q, Chan HL, Liu Z et al. A1762T/G1764A mutations of hepatitis B virus, associated with the increased risk of hepatocellular carcinoma, reduce basal core promoter activities. Biochem Biophys Res Commun 2008; 374: 773-6.
28. Kim JK, Chang HY, Lee JM et al. Specific mutations in the enhancer II/core promoter/precore regions of hepatitis B virus subgenotype C2 in Korean patients with hepatocellular carcinoma. J Med Virol 2009; 81: 1002-8.
29. Yuan JM, Ambinder A, Fan Y et al. Prospective evaluation of hepatitis B 1762(T)/1764(A) mutations on hepatocellular carcinoma development in Shanghai, China. Cancer Epidemiol Biomarkers Prev 2009; 18: 590-4.
30. Fang ZL, Sabin CA, Dong BQ et al. HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study. Am J Gastroenterol 2008; 103: 2254-62.
31. Liu CJ, Kao JH. Core promoter mutations of hepatitis B virus and hepatocellular carcinoma: story beyond A1762T/G1764A mutations. J Gastroenterol Hepatol 2008; 23: 347-50.
32. Liu S, Zhang H, Gu C et al. Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis. J Natl Cancer Inst 2009; 101: 1066-82.
33. Choi CS, Cho EY, Park R et al. X gene mutations in hepatitis B patients with cirrhosis, with and without hepatocellular carcinoma. J Med Virol 2009; 81: 1721-5.
34. Livingston SE, Simonetti JP, McMahon BJ et al. Hepatitis B virus genotypes in Alaska native people with hepatocellular carcinoma: preponderance of genotype F. J Infect Dis 2007; 195: 5-11.
35. Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology 2007; 45: 507-39.
36. Zhang HW, Yin JH, Li YT et al. Risk factors for acute hepatitis B and its progression to chronic hepatitis in Shanghai, China. Gut 2008; 57: 1713-20.
37. Liu S, Xie J, Yin J et al. A matched case-control study of hepatitis B virus mutations in the preS and core promoter regions associated independently with hepatocellular carcinoma. J Med Virol 2010; doi:10.1002/jmv.00000 (in press).
38. Tamura K, Dudley J, Nei M et al. MEGA4: molecular evolutionary genetics analysis (MEGA) soft ware version 4.0. Mol Biol Evol 2007; 24: 1596-9.
39. Tangkijvanich P, Komolmit P, Mahachai V et al. Low pretreatment serum HBsAg level and viral mutations as predictors of response to PEG-interferon alpha-2b therapy in chronic hepatitis B. J Clin Virol 2009; 46: 117-23.
40. Chen CH, Lee CM, Lu SN et al. Clinical significance of hepatitis B virus (HBV) genotypes and precore and core promoter mutations affecting HBV e antigen expression in Taiwan. J Clin Microbiol 2005; 43: 6000-6.
41. Fung J, Lai CL, But D et al. Prevalence of fibrosis and cirrhosis in chronic hepatitis B: implications for treatment and management. Am J Gastroenterol 2008; 103: 1421-6.
42. Chu CM, Liaw YF. Incidence and risk factors of progression to cirrhosis in inactive carriers of hepatitis B virus. Am J Gastroenterol 2009; 104: 1693-9.
43. Nguyen MH, Garcia RT, Trinh HN et al. Histological disease in Asian-Americans with chronic hepatitis B, high hepatitis B virus DNA, and normal alanine aminotransferase levels. Am J Gastroenterol 2009; 104: 2206-13.
44. Chen CH, Hung CH, Lee CM et al. Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients. Gastroenterology 2007; 133: 1466-74.
45. Wong GL, Wong VW, Choi PC et al. Evaluation of alanine transaminase and hepatitis B virus DNA to predict liver cirrhosis in hepatitis B e antigennegative chronic hepatitis B using transient elastography. Am J Gastroenterol 2008; 103: 3071-81.
46. Cheng H, Su H, Wang S et al. Association between genomic heterogeneity of hepatitis B virus and intrauterine infection. Virology 2009; 387: 168-75.
47. Shen T, Yan XM, Zou YL et al. Virologic characteristics of hepatitis B virus in patients infected via maternal-fetal transmission. World J Gastroenterol 2008; 14: 5674-82.
48. Long Y, Chen E, Liu C et al. The correlation of hepatocyte nuclear factor 4 alpha and 3 beta with hepatitis B virus replication in the liver of chronic hepatitis B patients. J Viral Hepat 2009; 16: 537-46.
49. Jonckheere N, Vincent A, Perrais M et al. The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. J Biol Chem 2007; 282: 22638-50.
50. Yanagiya A, Svitkin YV, Shibata S et al. Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap. Mol Cell Biol 2009; 29: 1661-9.
51. Wang Y, Lau SH, Sham JS et al. Characterization of HBV integrants in 14 hepatocellular carcinomas: association of truncated X gene and hepatocellular carcinogenesis. Oncogene 2004; 23: 142-8.
52. Chen GG, Li MY, Ho RL et al. Identification of hepatitis B virus X gene mutation in Hong Kong patients with hepatocellular carcinoma. J Clin Virol 2005; 34: 7-12.
53. Hussain SP, Schwank J, Staib F et al. TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene 2007; 26: 2166-76.
54. Parekh S, Zoulim F, Ahn S et al. Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants. J Virol 2003; 77: 6601-12.
55. Hung IF, Poon RT, Lai CL et al. Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection. Am J Gastroenterol 2008; 103: 1663-73.