메뉴 건너뛰기




Volumn 7, Issue 8, 2012, Pages

A novel highly potent therapeutic antibody neutralizes multiple human chemokines and mimics viral immune modulation

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR5; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PROTEIN ANTIBODY; RANTES;

EID: 84865101784     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043332     Document Type: Article
Times cited : (8)

References (66)
  • 1
    • 50049123401 scopus 로고    scopus 로고
    • Chemokines and leukocyte traffic
    • Sallusto F, Baggiolini M, (2008) Chemokines and leukocyte traffic. Nat Immunol 9: 949-952.
    • (2008) Nat Immunol , vol.9 , pp. 949-952
    • Sallusto, F.1    Baggiolini, M.2
  • 2
    • 0034080318 scopus 로고    scopus 로고
    • The biology of chemokines and their receptors
    • Rossi D, Zlotnik A, (2000) The biology of chemokines and their receptors. Annu Rev Immunol 18: 217-242.
    • (2000) Annu Rev Immunol , vol.18 , pp. 217-242
    • Rossi, D.1    Zlotnik, A.2
  • 3
    • 0038011833 scopus 로고    scopus 로고
    • Evolving concepts of rheumatoid arthritis
    • Firestein GS, (2003) Evolving concepts of rheumatoid arthritis. Nature 423: 356-361.
    • (2003) Nature , vol.423 , pp. 356-361
    • Firestein, G.S.1
  • 4
    • 0031739621 scopus 로고    scopus 로고
    • Etiology and pathogenesis of multiple sclerosis
    • Sorensen TL, Ransohoff RM, (1998) Etiology and pathogenesis of multiple sclerosis. Semin Neurol 18: 287-294.
    • (1998) Semin Neurol , vol.18 , pp. 287-294
    • Sorensen, T.L.1    Ransohoff, R.M.2
  • 5
    • 77958123700 scopus 로고    scopus 로고
    • The role of natalizumab in the treatment of multiple sclerosis
    • Coyle PK, (2010) The role of natalizumab in the treatment of multiple sclerosis. Am J Manag Care 16: S164-170.
    • (2010) Am J Manag Care , vol.16
    • Coyle, P.K.1
  • 6
    • 33144463109 scopus 로고    scopus 로고
    • Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis
    • Haringman JJ, Smeets TJ, Reinders-Blankert P, Tak PP, (2006) Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis. Ann Rheum Dis 65: 294-300.
    • (2006) Ann Rheum Dis , vol.65 , pp. 294-300
    • Haringman, J.J.1    Smeets, T.J.2    Reinders-Blankert, P.3    Tak, P.P.4
  • 8
    • 0343396569 scopus 로고    scopus 로고
    • Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis
    • Katschke KJ Jr, Rottman JB, Ruth JH, Qin S, Wu L, et al. (2001) Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis. Arthritis Rheum 44: 1022-1032.
    • (2001) Arthritis Rheum , vol.44 , pp. 1022-1032
    • Katschke Jr., K.J.1    Rottman, J.B.2    Ruth, J.H.3    Qin, S.4    Wu, L.5
  • 9
    • 0033559346 scopus 로고    scopus 로고
    • Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients
    • Sorensen TL, Tani M, Jensen J, Pierce V, Lucchinetti C, et al. (1999) Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest 103: 807-815.
    • (1999) J Clin Invest , vol.103 , pp. 807-815
    • Sorensen, T.L.1    Tani, M.2    Jensen, J.3    Pierce, V.4    Lucchinetti, C.5
  • 10
    • 0033536062 scopus 로고    scopus 로고
    • CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions
    • Balashov KE, Rottman JB, Weiner HL, Hancock WW, (1999) CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions. Proc Natl Acad Sci U S A 96: 6873-6878.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 6873-6878
    • Balashov, K.E.1    Rottman, J.B.2    Weiner, H.L.3    Hancock, W.W.4
  • 11
    • 0035157253 scopus 로고    scopus 로고
    • CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis
    • Trebst C, Sorensen TL, Kivisakk P, Cathcart MK, Hesselgesser J, et al. (2001) CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis. Am J Pathol 159: 1701-1710.
    • (2001) Am J Pathol , vol.159 , pp. 1701-1710
    • Trebst, C.1    Sorensen, T.L.2    Kivisakk, P.3    Cathcart, M.K.4    Hesselgesser, J.5
  • 12
    • 1542327620 scopus 로고    scopus 로고
    • Expression of chemokine receptors CCR1 and CCR5 reflects differential activation of mononuclear phagocytes in pattern II and pattern III multiple sclerosis lesions
    • Mahad DJ, Trebst C, Kivisakk P, Staugaitis SM, Tucky B, et al. (2004) Expression of chemokine receptors CCR1 and CCR5 reflects differential activation of mononuclear phagocytes in pattern II and pattern III multiple sclerosis lesions. J Neuropathol Exp Neurol 63: 262-273.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 262-273
    • Mahad, D.J.1    Trebst, C.2    Kivisakk, P.3    Staugaitis, S.M.4    Tucky, B.5
  • 13
    • 0032522207 scopus 로고    scopus 로고
    • Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions
    • Simpson JE, Newcombe J, Cuzner ML, Woodroofe MN, (1998) Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions. J Neuroimmunol 84: 238-249.
    • (1998) J Neuroimmunol , vol.84 , pp. 238-249
    • Simpson, J.E.1    Newcombe, J.2    Cuzner, M.L.3    Woodroofe, M.N.4
  • 14
    • 18944402657 scopus 로고    scopus 로고
    • Proteolytic activation of alternative CCR1 ligands in inflammation
    • Berahovich RD, Miao Z, Wang Y, Premack B, Howard MC, et al. (2005) Proteolytic activation of alternative CCR1 ligands in inflammation. J Immunol 174: 7341-7351.
    • (2005) J Immunol , vol.174 , pp. 7341-7351
    • Berahovich, R.D.1    Miao, Z.2    Wang, Y.3    Premack, B.4    Howard, M.C.5
  • 15
    • 0032525890 scopus 로고    scopus 로고
    • Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model
    • Barnes DA, Tse J, Kaufhold M, Owen M, Hesselgesser J, et al. (1998) Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model. J Clin Invest 101: 2910-2919.
    • (1998) J Clin Invest , vol.101 , pp. 2910-2919
    • Barnes, D.A.1    Tse, J.2    Kaufhold, M.3    Owen, M.4    Hesselgesser, J.5
  • 16
    • 2442700643 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in autoimmune encephalomyelitis as a model for central nervous system inflammatory disease regulation
    • Dogan RN, Karpus WJ, (2004) Chemokines and chemokine receptors in autoimmune encephalomyelitis as a model for central nervous system inflammatory disease regulation. Front Biosci 9: 1500-1505.
    • (2004) Front Biosci , vol.9 , pp. 1500-1505
    • Dogan, R.N.1    Karpus, W.J.2
  • 17
    • 33750969668 scopus 로고    scopus 로고
    • Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo
    • Amat M, Benjamim CF, Williams LM, Prats N, Terricabras E, et al. (2006) Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo. Br J Pharmacol 149: 666-675.
    • (2006) Br J Pharmacol , vol.149 , pp. 666-675
    • Amat, M.1    Benjamim, C.F.2    Williams, L.M.3    Prats, N.4    Terricabras, E.5
  • 18
    • 0029051330 scopus 로고
    • Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis
    • Kasama T, Strieter RM, Lukacs NW, Lincoln PM, Burdick MD, et al. (1995) Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin Invest 95: 2868-2876.
    • (1995) J Clin Invest , vol.95 , pp. 2868-2876
    • Kasama, T.1    Strieter, R.M.2    Lukacs, N.W.3    Lincoln, P.M.4    Burdick, M.D.5
  • 19
    • 0034026891 scopus 로고    scopus 로고
    • Induction of experimental autoimmune encephalomyelitis in C57BL/6 mice deficient in either the chemokine macrophage inflammatory protein-1alpha or its CCR5 receptor
    • Tran EH, Kuziel WA, Owens T, (2000) Induction of experimental autoimmune encephalomyelitis in C57BL/6 mice deficient in either the chemokine macrophage inflammatory protein-1alpha or its CCR5 receptor. Eur J Immunol 30: 1410-1415.
    • (2000) Eur J Immunol , vol.30 , pp. 1410-1415
    • Tran, E.H.1    Kuziel, W.A.2    Owens, T.3
  • 20
    • 0036687024 scopus 로고    scopus 로고
    • A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses
    • Yang YF, Mukai T, Gao P, Yamaguchi N, Ono S, et al. (2002) A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses. Eur J Immunol 32: 2124-2132.
    • (2002) Eur J Immunol , vol.32 , pp. 2124-2132
    • Yang, Y.F.1    Mukai, T.2    Gao, P.3    Yamaguchi, N.4    Ono, S.5
  • 21
    • 58149178530 scopus 로고    scopus 로고
    • Chemokine receptor antagonists: overcoming developmental hurdles
    • Horuk R, (2009) Chemokine receptor antagonists: overcoming developmental hurdles. Nat Rev Drug Discov 8: 23-33.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 23-33
    • Horuk, R.1
  • 22
    • 79955476625 scopus 로고    scopus 로고
    • Overcoming hurdles in developing successful drugs targeting chemokine receptors
    • Schall TJ, Proudfoot AE, (2011) Overcoming hurdles in developing successful drugs targeting chemokine receptors. Nat Rev Immunol 11: 355-363.
    • (2011) Nat Rev Immunol , vol.11 , pp. 355-363
    • Schall, T.J.1    Proudfoot, A.E.2
  • 23
    • 0037271850 scopus 로고    scopus 로고
    • Viral mimicry of cytokines, chemokines and their receptors
    • Alcami A, (2003) Viral mimicry of cytokines, chemokines and their receptors. Nat Rev Immunol 3: 36-50.
    • (2003) Nat Rev Immunol , vol.3 , pp. 36-50
    • Alcami, A.1
  • 25
    • 0342506481 scopus 로고    scopus 로고
    • Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors
    • Smith CA, Smith TD, Smolak PJ, Friend D, Hagen H, et al. (1997) Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors. Virology 236: 316-327.
    • (1997) Virology , vol.236 , pp. 316-327
    • Smith, C.A.1    Smith, T.D.2    Smolak, P.J.3    Friend, D.4    Hagen, H.5
  • 26
    • 0037169511 scopus 로고    scopus 로고
    • Comprehensive mapping of poxvirus vCCI chemokine-binding protein. Expanded range of ligand interactions and unusual dissociation kinetics
    • Burns JM, Dairaghi DJ, Deitz M, Tsang M, Schall TJ, (2002) Comprehensive mapping of poxvirus vCCI chemokine-binding protein. Expanded range of ligand interactions and unusual dissociation kinetics. J Biol Chem 277: 2785-2789.
    • (2002) J Biol Chem , vol.277 , pp. 2785-2789
    • Burns, J.M.1    Dairaghi, D.J.2    Deitz, M.3    Tsang, M.4    Schall, T.J.5
  • 27
    • 77956940247 scopus 로고    scopus 로고
    • Pan-CC chemokine neutralization restricts splenocyte egress and reduces inflammation in a model of arthritis
    • Buatois V, Fagete S, Magistrelli G, Chatel L, Fischer N, et al. (2010) Pan-CC chemokine neutralization restricts splenocyte egress and reduces inflammation in a model of arthritis. J Immunol 185: 2544-2554.
    • (2010) J Immunol , vol.185 , pp. 2544-2554
    • Buatois, V.1    Fagete, S.2    Magistrelli, G.3    Chatel, L.4    Fischer, N.5
  • 28
    • 48049089376 scopus 로고    scopus 로고
    • Monkeypox virus viral chemokine inhibitor (MPV vCCI), a potent inhibitor of rhesus macrophage inflammatory protein-1
    • Jones JM, Messauodi I, Estep RD, Orzechowska B, Wong SW, (2008) Monkeypox virus viral chemokine inhibitor (MPV vCCI), a potent inhibitor of rhesus macrophage inflammatory protein-1. Cytokine 43: 220-228.
    • (2008) Cytokine , vol.43 , pp. 220-228
    • Jones, J.M.1    Messauodi, I.2    Estep, R.D.3    Orzechowska, B.4    Wong, S.W.5
  • 29
    • 0026084577 scopus 로고
    • Rapid PCR-cloning of full-length mouse immunoglobulin variable regions
    • Jones ST, Bendig MM, (1991) Rapid PCR-cloning of full-length mouse immunoglobulin variable regions. Biotechnology (N Y) 9: 579.
    • (1991) Biotechnology (N Y) , vol.9 , pp. 579
    • Jones, S.T.1    Bendig, M.M.2
  • 33
    • 0023613953 scopus 로고
    • Rapid and efficient site-specific mutagenesis without phenotypic selection
    • Kunkel TA, Roberts JD, Zakour RA, (1987) Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol 154: 367-382.
    • (1987) Methods Enzymol , vol.154 , pp. 367-382
    • Kunkel, T.A.1    Roberts, J.D.2    Zakour, R.A.3
  • 35
    • 0033522887 scopus 로고    scopus 로고
    • Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants
    • Czaplewski LG, McKeating J, Craven CJ, Higgins LD, Appay V, et al. (1999) Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants. J Biol Chem 274: 16077-16084.
    • (1999) J Biol Chem , vol.274 , pp. 16077-16084
    • Czaplewski, L.G.1    McKeating, J.2    Craven, C.J.3    Higgins, L.D.4    Appay, V.5
  • 37
    • 2942709860 scopus 로고    scopus 로고
    • High-level expression of proteins in mammalian cells using transcription regulatory sequences from the Chinese hamster EF-1alpha gene
    • Running Deer J, Allison DS, (2004) High-level expression of proteins in mammalian cells using transcription regulatory sequences from the Chinese hamster EF-1alpha gene. Biotechnol Prog 20: 880-889.
    • (2004) Biotechnol Prog , vol.20 , pp. 880-889
    • Running Deer, J.1    Allison, D.S.2
  • 38
    • 0032810008 scopus 로고    scopus 로고
    • Recombinant human IgG molecules lacking Fcgamma receptor I binding and monocyte triggering activities
    • Armour KL, Clark MR, Hadley AG, Williamson LM, (1999) Recombinant human IgG molecules lacking Fcgamma receptor I binding and monocyte triggering activities. Eur J Immunol 29: 2613-2624.
    • (1999) Eur J Immunol , vol.29 , pp. 2613-2624
    • Armour, K.L.1    Clark, M.R.2    Hadley, A.G.3    Williamson, L.M.4
  • 39
    • 57349120616 scopus 로고    scopus 로고
    • A novel CCR5-specific pharmacodynamic assay in whole blood using phosphoflow cytometry highlights different ligand-dependent responses but similar properties of antagonists in CD8+ and CD4+ T lymphocytes
    • Dahl ME, Berson A, Lora J, Fuentes M, (2008) A novel CCR5-specific pharmacodynamic assay in whole blood using phosphoflow cytometry highlights different ligand-dependent responses but similar properties of antagonists in CD8+ and CD4+ T lymphocytes. J Pharmacol Exp Ther 327: 926-933.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 926-933
    • Dahl, M.E.1    Berson, A.2    Lora, J.3    Fuentes, M.4
  • 40
    • 17144455876 scopus 로고    scopus 로고
    • Chemokine-dependent upregulation of CD11b on specific leukocyte subpopulations in human whole blood: effect of anticoagulant on rantes and MIP-1 beta stimulation
    • Conklyn MJ, Neote K, Showell HJ, (1996) Chemokine-dependent upregulation of CD11b on specific leukocyte subpopulations in human whole blood: effect of anticoagulant on rantes and MIP-1 beta stimulation. Cytokine 8: 762-766.
    • (1996) Cytokine , vol.8 , pp. 762-766
    • Conklyn, M.J.1    Neote, K.2    Showell, H.J.3
  • 41
    • 33646352962 scopus 로고    scopus 로고
    • Potent antibody therapeutics by design
    • Carter PJ, (2006) Potent antibody therapeutics by design. Nat Rev Immunol 6: 343-357.
    • (2006) Nat Rev Immunol , vol.6 , pp. 343-357
    • Carter, P.J.1
  • 42
    • 0026699293 scopus 로고
    • Selection of phage antibodies by binding affinity. Mimicking affinity maturation
    • Hawkins RE, Russell SJ, Winter G, (1992) Selection of phage antibodies by binding affinity. Mimicking affinity maturation. J Mol Biol 226: 889-896.
    • (1992) J Mol Biol , vol.226 , pp. 889-896
    • Hawkins, R.E.1    Russell, S.J.2    Winter, G.3
  • 43
    • 0030485173 scopus 로고    scopus 로고
    • Efficient in vitro affinity maturation of phage antibodies using BIAcore guided selections
    • Schier R, Marks JD, (1996) Efficient in vitro affinity maturation of phage antibodies using BIAcore guided selections. Hum Antibodies Hybridomas 7: 97-105.
    • (1996) Hum Antibodies Hybridomas , vol.7 , pp. 97-105
    • Schier, R.1    Marks, J.D.2
  • 44
    • 33747172021 scopus 로고    scopus 로고
    • Diverse signalling by different chemokines through the chemokine receptor CCR5
    • Mueller A, Mahmoud NG, Strange PG, (2006) Diverse signalling by different chemokines through the chemokine receptor CCR5. Biochem Pharmacol 72: 739-748.
    • (2006) Biochem Pharmacol , vol.72 , pp. 739-748
    • Mueller, A.1    Mahmoud, N.G.2    Strange, P.G.3
  • 45
    • 0037199997 scopus 로고    scopus 로고
    • Natural truncation of the chemokine MIP-1 beta/CCL4 affects receptor specificity but not anti-HIV-1 activity
    • Guan E, Wang J, Roderiquez G, Norcross MA, (2002) Natural truncation of the chemokine MIP-1 beta/CCL4 affects receptor specificity but not anti-HIV-1 activity. J Biol Chem 277: 32348-32352.
    • (2002) J Biol Chem , vol.277 , pp. 32348-32352
    • Guan, E.1    Wang, J.2    Roderiquez, G.3    Norcross, M.A.4
  • 46
    • 0009025445 scopus 로고    scopus 로고
    • The CC chemokine MIP-1alpha induces a selective monocyte infiltration following intradermal injection into nonhuman primates
    • Didier PJ, Paradis TJ, Gladue RP, (1999) The CC chemokine MIP-1alpha induces a selective monocyte infiltration following intradermal injection into nonhuman primates. Inflammation 23: 75-86.
    • (1999) Inflammation , vol.23 , pp. 75-86
    • Didier, P.J.1    Paradis, T.J.2    Gladue, R.P.3
  • 47
    • 0036481769 scopus 로고    scopus 로고
    • Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis
    • Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, et al. (2002) Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. FASEB J 16: 219-221.
    • (2002) FASEB J , vol.16 , pp. 219-221
    • Inoki, I.1    Shiomi, T.2    Hashimoto, G.3    Enomoto, H.4    Nakamura, H.5
  • 48
    • 0037298570 scopus 로고    scopus 로고
    • The SCID-hu Skin mouse as a model to investigate selective chemokine mediated homing of human T-lymphocytes to the skin in vivo
    • Carballido JM, Biedermann T, Schwarzler C, de Vries JE, (2003) The SCID-hu Skin mouse as a model to investigate selective chemokine mediated homing of human T-lymphocytes to the skin in vivo. J Immunol Methods 273: 125-135.
    • (2003) J Immunol Methods , vol.273 , pp. 125-135
    • Carballido, J.M.1    Biedermann, T.2    Schwarzler, C.3    de Vries, J.E.4
  • 49
    • 0033849381 scopus 로고    scopus 로고
    • Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent
    • Rottman JB, Slavin AJ, Silva R, Weiner HL, Gerard CG, et al. (2000) Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent. Eur J Immunol 30: 2372-2377.
    • (2000) Eur J Immunol , vol.30 , pp. 2372-2377
    • Rottman, J.B.1    Slavin, A.J.2    Silva, R.3    Weiner, H.L.4    Gerard, C.G.5
  • 50
    • 14144255210 scopus 로고    scopus 로고
    • Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritis
    • Pokorny V, McQueen F, Yeoman S, Merriman M, Merriman A, et al. (2005) Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritis. Ann Rheum Dis 64: 487-490.
    • (2005) Ann Rheum Dis , vol.64 , pp. 487-490
    • Pokorny, V.1    McQueen, F.2    Yeoman, S.3    Merriman, M.4    Merriman, A.5
  • 51
    • 33646152126 scopus 로고    scopus 로고
    • Negative association between the chemokine receptor CCR5-Delta32 polymorphism and rheumatoid arthritis: a meta-analysis
    • Prahalad S, (2006) Negative association between the chemokine receptor CCR5-Delta32 polymorphism and rheumatoid arthritis: a meta-analysis. Genes Immun 7: 264-268.
    • (2006) Genes Immun , vol.7 , pp. 264-268
    • Prahalad, S.1
  • 52
    • 67650403809 scopus 로고    scopus 로고
    • Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis
    • Rossol M, Pierer M, Arnold S, Keysser G, Burkhardt H, et al. (2009) Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis. Arthritis Res Ther 11: R91.
    • (2009) Arthritis Res Ther , vol.11
    • Rossol, M.1    Pierer, M.2    Arnold, S.3    Keysser, G.4    Burkhardt, H.5
  • 53
    • 0033622321 scopus 로고    scopus 로고
    • CCR5 delta32, matrix metalloproteinase-9 and disease activity in multiple sclerosis
    • Sellebjerg F, Madsen HO, Jensen CV, Jensen J, Garred P, (2000) CCR5 delta32, matrix metalloproteinase-9 and disease activity in multiple sclerosis. J Neuroimmunol 102: 98-106.
    • (2000) J Neuroimmunol , vol.102 , pp. 98-106
    • Sellebjerg, F.1    Madsen, H.O.2    Jensen, C.V.3    Jensen, J.4    Garred, P.5
  • 54
    • 0034070679 scopus 로고    scopus 로고
    • CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis. Multiple Sclerosis Genetics Group
    • Barcellos LF, Schito AM, Rimmler JB, Vittinghoff E, Shih A, et al. (2000) CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis. Multiple Sclerosis Genetics Group. Immunogenetics 51: 281-288.
    • (2000) Immunogenetics , vol.51 , pp. 281-288
    • Barcellos, L.F.1    Schito, A.M.2    Rimmler, J.B.3    Vittinghoff, E.4    Shih, A.5
  • 55
    • 35648997076 scopus 로고    scopus 로고
    • The chemokine receptor CCR5 genetic polymorphism and expression in rheumatoid arthritis patients
    • Kohem CL, Brenol JC, Xavier RM, Bredemeier M, Brenol CV, et al. (2007) The chemokine receptor CCR5 genetic polymorphism and expression in rheumatoid arthritis patients. Scand J Rheumatol 36: 359-364.
    • (2007) Scand J Rheumatol , vol.36 , pp. 359-364
    • Kohem, C.L.1    Brenol, J.C.2    Xavier, R.M.3    Bredemeier, M.4    Brenol, C.V.5
  • 56
    • 0034568503 scopus 로고    scopus 로고
    • CCR5 (chemokine receptor-5) DNA-polymorphism influences the severity of rheumatoid arthritis
    • Zapico I, Coto E, Rodriguez A, Alvarez C, Torre JC, et al. (2000) CCR5 (chemokine receptor-5) DNA-polymorphism influences the severity of rheumatoid arthritis. Genes Immun 1: 288-289.
    • (2000) Genes Immun , vol.1 , pp. 288-289
    • Zapico, I.1    Coto, E.2    Rodriguez, A.3    Alvarez, C.4    Torre, J.C.5
  • 57
    • 3042741204 scopus 로고    scopus 로고
    • Influence of CCR5 delta32 polymorphism on multiple sclerosis susceptibility and disease course
    • Silversides JA, Heggarty SV, McDonnell GV, Hawkins SA, Graham CA, (2004) Influence of CCR5 delta32 polymorphism on multiple sclerosis susceptibility and disease course. Mult Scler 10: 149-152.
    • (2004) Mult Scler , vol.10 , pp. 149-152
    • Silversides, J.A.1    Heggarty, S.V.2    McDonnell, G.V.3    Hawkins, S.A.4    Graham, C.A.5
  • 59
    • 84862776995 scopus 로고    scopus 로고
    • Maraviroc, a chemokine receptor-5 antagonist, fails to demonstrate efficacy in the treatment of patients with rheumatoid arthritis in a randomized, double-blind placebo-controlled trial
    • Fleishaker DL, Garcia Meijide JA, Petrov A, Kohen MD, Wang X, et al. (2012) Maraviroc, a chemokine receptor-5 antagonist, fails to demonstrate efficacy in the treatment of patients with rheumatoid arthritis in a randomized, double-blind placebo-controlled trial. Arthritis Res Ther 14: R11.
    • (2012) Arthritis Res Ther , vol.14
    • Fleishaker, D.L.1    Garcia Meijide, J.A.2    Petrov, A.3    Kohen, M.D.4    Wang, X.5
  • 60
    • 85028106569 scopus 로고    scopus 로고
    • Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial
    • Tak PP, Balanescu A, Tseluyko V, Bojin S, Drescher E, et al. (2012) Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial. Ann Rheum Dis.
    • (2012) Ann Rheum Dis.
    • Tak, P.P.1    Balanescu, A.2    Tseluyko, V.3    Bojin, S.4    Drescher, E.5
  • 61
    • 77954650443 scopus 로고    scopus 로고
    • Anti-inflammatory drug development: Broad or specific chemokine receptor antagonists?
    • Russo RC, Garcia CC, Teixeira MM, (2010) Anti-inflammatory drug development: Broad or specific chemokine receptor antagonists? Curr Opin Drug Discov Devel 13: 414-427.
    • (2010) Curr Opin Drug Discov Devel , vol.13 , pp. 414-427
    • Russo, R.C.1    Garcia, C.C.2    Teixeira, M.M.3
  • 62
    • 77953664138 scopus 로고    scopus 로고
    • Specificity tuning of antibody fragments to neutralize two human chemokines with a single agent
    • Fagete S, Ravn U, Gueneau F, Magistrelli G, Kosco-Vilbois MH, et al. (2009) Specificity tuning of antibody fragments to neutralize two human chemokines with a single agent. MAbs 1: 288-296.
    • (2009) MAbs , vol.1 , pp. 288-296
    • Fagete, S.1    Ravn, U.2    Gueneau, F.3    Magistrelli, G.4    Kosco-Vilbois, M.H.5
  • 63
    • 0036295742 scopus 로고    scopus 로고
    • Treatment of experimental autoimmune encephalomyelitis with the chemokine receptor antagonist Met-RANTES
    • Matsui M, Weaver J, Proudfoot AE, Wujek JR, Wei T, et al. (2002) Treatment of experimental autoimmune encephalomyelitis with the chemokine receptor antagonist Met-RANTES. J Neuroimmunol 128: 16-22.
    • (2002) J Neuroimmunol , vol.128 , pp. 16-22
    • Matsui, M.1    Weaver, J.2    Proudfoot, A.E.3    Wujek, J.R.4    Wei, T.5
  • 64
  • 65
    • 77956923012 scopus 로고    scopus 로고
    • A fusion protein encoding the second extracellular domain of CCR5 arrests chemokine-induced cosignaling and effectively suppresses ongoing experimental autoimmune encephalomyelitis
    • Sapir Y, Vitenshtein A, Barsheshet Y, Zohar Y, Wildbaum G, et al. (2010) A fusion protein encoding the second extracellular domain of CCR5 arrests chemokine-induced cosignaling and effectively suppresses ongoing experimental autoimmune encephalomyelitis. J Immunol 185: 2589-2599.
    • (2010) J Immunol , vol.185 , pp. 2589-2599
    • Sapir, Y.1    Vitenshtein, A.2    Barsheshet, Y.3    Zohar, Y.4    Wildbaum, G.5
  • 66
    • 33745712854 scopus 로고    scopus 로고
    • Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody
    • Reid C, Rushe M, Jarpe M, van Vlijmen H, Dolinski B, et al. (2006) Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody. Protein Eng Des Sel 19: 317-324.
    • (2006) Protein Eng Des Sel , vol.19 , pp. 317-324
    • Reid, C.1    Rushe, M.2    Jarpe, M.3    van Vlijmen, H.4    Dolinski, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.