Recombinant human IgG molecules lacking Fcγ receptor I binding and monocyte triggering activities

European Journal of Immunology

Volumn 29, Issue 8, 1999, Pages 2613-2624

  Armour, Kathryn L ^a   Clark, Mike R ^a   Hadley, Andrew G ^b   Williamson, Lorna M ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

Author keywords

Fc receptor; IgG effector function; Monocyte chemiluminescence; Structural motif

Indexed keywords

FC RECEPTOR; GLYCINE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G4;

ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOGENICITY; MONOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES, ANTIBODY; CELL LINE; CHEMILUMINESCENT MEASUREMENTS; HUMANS; IMMUNOGLOBULIN G; MONOCYTES; MUTATION; PROTEIN ENGINEERING; RECEPTORS, IGG; RECOMBINANT PROTEINS; ROSETTE FORMATION; TRANSFECTION;

EID: 0032810008     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199908)29:08<2613::AID-IMMU2613>3.0.CO;2-J     Document Type: Article

References (33)

1. a) as determined by antenatal screening. Blood 1998. 92: 2280-2287.
2. A1, HPA-1a) form of platelet glycoprotein IIIa from a V gene phage display library. Blood 1995. 86: 4430-4436.
3. Clark, M. R., IgG effector mechanisms. Chem. Immunol. 1997. 65: 88-110.
4. Burton, D. R., Immunoglobulin G: functional sites. Mol. Immunol. 1985. 22: 161-206.
5. Chappel, M. S., Isenman, D. E., Everett, M., Xu, Y.-Y., Dorrington, K. J. and Klein, M. H., Identification of the Fcγ receptor class I binding site in human IgG through the use of recombinant IgG1/IgG2 hybrid and point-mutated antibodies. Proc. Natl. Acad. Sci. USA 1991. 88: 9036-9040.
6. Cranfield, S. M. and Morrison, S. L., The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region. J. Exp. Med. 1991. 173: 1483-1491.
7. Kabat, E. A., Wu, T. T., Perry, H. M., Gottesman, K. S. and Foeller, C., Sequences of proteins of immunological interest. US Department of Health and Human services, NIH, Bethesda 1991.
8. Deisenhofer, J., Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9 and 2.8 Å resolution. Biochemistry 1981. 20: 2361-2367.
9. Duncan, A. R., Woof, J. M., Partridge, L. J., Burton, D. R. and Winter, G., Localization of the binding site for the human high-affinity Fc receptor on IgG. Nature 1988. 332: 563-564.
10. Morgan, A., Jones, N. D., Nesbitt, A. M., Chaplin, L., Bodmer, M. W. and Emtage, J. S., The N-terminal end of the CH2 domain of chimeric human IgG1 anti-HLA-DR is necessary for C1q, FcγRI and FcγRIII binding. Immunology 1995. 86: 319-324.
11. Lund, J., Winter, G., Jones, P. T., Pound, J. D., Tanaka, T., Walker, M. R., Artymiuk, P. J., Arata, Y., Burton, D. R., Jefferis, R. and Woof, J. M., Human FcγRI and FcγRII interact with distinct but overlapping sites on human IgG. J. Immunol. 1991. 147: 2657-2662.
12. Gergely, J. and Sarmay, G., The two binding-site models of human IgG binding Fcγ receptors. FASEB J. 1990. 4: 3275-3283.
13. Riechmann, L., Clark, M. R., Waldmann, H. and Winter, G., Reshaping human antibodies for therapy. Nature 1988. 332: 323-327.
14. Bye, J. M., Carter, C., Cui, Y., Gorick, B. D., Songsivilai, S., Winter, G., Hughes-Jones, N. C. and Marks, J. D., Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. J. Clin. Invest. 1992. 90: 2481-2490.
15. Kumpel, B. M. and Hadley, A. G., Functional interactions of red cells sensitized by IgG1 and IgG3 human monoclonal anti-D with enzyme-modified human monocytes and FcR-bearing cell lines. Mol. Immunol. 1990. 27: 247-256.
16. Hadley, A. G., In vitro assays to predict the severity of hemolytic disease of the newborn. Transfus. Med. Rev. 1995. 9: 302-313.
17. Hadley, A. G., Wilkes, A., Goodrick, J., Penman, D., Soothill, P. and Lucas, G., The ability of the chemiluminescense test to predict clinical outcome and the necessity for amniocenteses in pregnancies at risk of haemolytic disease of the newborn. Br. J. Obstet. Gynaecol. 1998. 105: 231-234.
18. Mawas, F., Wiener, E., Ryan, G., Soothill, P. W. and Rodeck, C. H., The expression of IgG Fc receptors on circulating leucocytes in the fetus and the new-born. Transfus. Med. 1994. 4: 25-33.
19. Wiener, E., Mawas, F., Dellow, R. A., Singh, I. and Rodeck, C. H., A major role of class I Fcγ receptors in immunoglobulin G anti-D-mediated red blood cell destruction by fetal mononuclear phagocytes. Obstet, Gynecol. 1995. 2: 157-162.
20. Wiener, E., Dellow, R. A., Mawas, F. and Rodeck, C. H., Role of FcγRIIa (CD32) in IgG anti-RhD-mediated red cell phagocytosis in vitro. Transfus. Med. 1996. 6: 235-241.
21. Pound, J. D., Lund, J. and Jefferis, R., Human FcγRI triggering of the mononuclear phagocyte respiratory burst. Mol. Immunol. 1993. 30: 469-478.
22. Koolwijk, P., Spierenburg, G. T., Frasa, H., Boot, J. H. A., van de Winkel, J. G. J. and Bast, B. J. E. G., Interaction between hybrid mouse monoclonal antibodies and the human high-affinity IgG FcR, huFcγRI, on U937. J. Immunol. 1989. 143: 1656-1662.
23. Harrison, P. T. and Allen, J. M., High affinity IgG binding by FcγRI (CD64) is modulated by two distinct IgSF domains and the transmembrane domain of the receptor. Protein Eng. 1998. 11: 225-232.
24. Story, C. M., Mikulska, J. E. and Simister, N. E., A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. J. Exp. Med. 1994. 180: 2377-2381.
25. Clark, M. R., Humanised antibodies having modified allotypic determinants (Immunoglobulin allotypes). Patent application WO 92/16562, 1992.
26. Greenwood, J., Clark, M. and Waldmann, H., Structural motifs involved in human IgG antibody effector functions. Eur. J. Immunol. 1993. 23: 1098-1104.
27. Orlandi, R., Gussow, D. H., Jones, P. T. and Winter, G., Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. Proc. Natl. Acad. Sci. USA 1989. 86: 3833-3837.
28. Kilmartin, J. V., Wright, B. and Milstein, C., Rat monoclonal antitubulin antibodies derived by using a new nonsecreting rat cell line. J. Cell. Biol. 1982. 93: 576-582.
29. Tempest, P. R., Bremner, P., Lambert, M., Taylor, G., Furze, J. M., Carr, F. J. and Harris, W. J., Reshaping a human monoclonal antibody to inhibit human respiratory syncytial virus infection in vivo. Biotechnology 1991. 9: 266-271.
30. Cobbold, S. P., Rebello, P. R. U. B., Davies, H. Ff. S., Friend, P. J. and Clark, M. R., A simple method for measuring patient anti-globulin responses against isotypic or idiotypic determinants. J. Immunol. Methods 1990. 127: 19-24.
31. van Urgt, M. J., Heijnen, I. A. F. M., Capel, P. J. A., Park, S. Y., Ra, C., Saito, T., Verbeek, J. S. and van de Winkel, J. G. J., FcR γ-chain is essential for both surface expression and function of human FcγRI (CD64) in vivo. Blood 1996. 87: 3593-3599.
32. Kumpel, B. M., Poole, G. D. and Bradley, B. A., Human monoclonal anti-D antibodies: their production, serology, quantitation and potential use as blood grouping reagents. Br. J. Haematol. 1989. 71: 125-129.
33. Kumpel, B. M., A simple non-isotopic method for the quantitation of red cell-bound immunoglobulin. Vox Sang. 1990. 59: 34-39.