Diverse signalling by different chemokines through the chemokine receptor CCR5

Biochemical Pharmacology

Volumn 72, Issue 6, 2006, Pages 739-748

  Mueller, Anja ^a   Mahmoud, Nasir G ^a   Strange, Philip G ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

35S GTP S binding; Ca2+ mobilisation; Chemokine receptor CCR5; Chemokines; Receptor internalisation

Indexed keywords

BUTYRIC ACID; CALCIUM; CHEMOKINE RECEPTOR AGONIST; CHEMOKINE RECEPTOR CCR5; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); ISOPROTEIN; LIGAND; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; METHIONINE; MONOCYTE CHEMOTACTIC PROTEIN 3; PROLINE; RANTES; SULFUR 35; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BIOASSAY; CALCIUM CELL LEVEL; CELL MEMBRANE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; ENZYME BINDING; FEMALE; IMMUNOSTIMULATION; MOLECULAR PROBE; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHEMOKINES; CHEMOKINES, CC; CHO CELLS; CRICETINAE; FEMALE; RECEPTORS, CCR5; SIGNAL TRANSDUCTION;

EID: 33747172021     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.06.001     Document Type: Article

References (36)

1. Samson M., Labbe O., Mollereau C., Vassart G., and Parmentier M. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 35 (1996) 3362-3367
2. Alkhatib G., Combadiere C., Broder C.C., Feng Y., Kennedy P.E., Murphy P.M., et al. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272 (1996) 1955-1958
3. Choe H., Farzan M., Sun Y., Sullivan N., Rollins B., Ponath P.D., et al. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85 (1996) 1135-1148
4. Doranz B.J., Rucker J., Yi Y., Smyth R.J., Samson M., Peiper S.C., et al. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85 (1996) 1149-1158
5. Dragic T., Litwin V., Allaway G.P., Martin S.R., Huang Y., Nagashima K.A., et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381 (1996) 667-673
6. Pitcher J.A., Freedman N.J., and Lefkowitz R.J. G protein-coupled receptor kinases. Annu Rev Biochem 67 (1998) 653-692
7. Mueller A., Kelly E., and Strange P.G. Pathways for internalization and recycling of the chemokine receptor CCR5. Blood 99 (2002) 785-791
8. Mueller A., Mahmoud N.G., Goedecke M.C., McKeating J.A., and Strange P.G. Pharmacological characterization of the chemokine receptor, CCR5. Br J Pharmacol 135 (2002) 1033-1043
9. Blanpain C., Migeotte I., Lee B., Vakili J., Doranz B.J., Govaerts C., et al. CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood 94 (1999) 1899-1905
10. Baggiolini M., and Dahinden C.A. CC chemokines in allergic inflammation. Immunol Today 15 (1994) 127-133
11. Baggiolini M., Dewald B., and Moser B. Human chemokines: an update. Annu Rev Immunol 15 (1997) 675-705
12. Mack M., Luckow B., Nelson P.J., Cihak J., Simmons G., Clapham P.R., et al. Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity. J Exp Med 187 (1998) 1215-1224
13. Vila-Coro A.J., Mellado M., Martin de Ana A., Martinez A.C., and Rodriguez-Frade J.M. Characterization of RANTES- and aminooxypentane-RANTES-triggered desensitization signals reveals differences in recruitment of the G protein-coupled receptor complex. J Immunol 163 (1999) 3037-3044
14. Townson J.R., Graham G.J., Landau N.R., Rasala B., and Nibbs R.J. Aminooxypentane addition to the chemokine macrophage inflammatory protein-1alpha P increases receptor affinities and HIV inhibition. J Biol Chem 275 (2000) 39254-39261
15. Proudfoot A.E., Power C.A., Hoogewerf A.J., Montjovent M.O., Borlat F., Offord R.E., et al. Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist. J Biol Chem 271 (1996) 2599-2603
16. Proudfoot A.E., Buser R., Borlat F., Alouani S., Soler D., Offord R.E., et al. Amino-terminally modified RANTES analogues demonstrate differential effects on RANTES receptors. J Biol Chem 274 (1999) 32478-32485
17. Elsner J., Petering H., Kimmig D., Wells T.N., Proudfoot A.E., and Kapp A. The CC chemokine receptor antagonist met-RANTES inhibits eosinophil effector functions. Int Arch Allergy Immunol 118 (1999) 462-465
18. Nibbs R.J., Yang J., Landau N.R., Mao J.H., and Graham G.J. LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity. J Biol Chem 274 (1999) 17478-17483
19. Dunlop D.J., Wright E.G., Lorimore S., Graham G.J., Holyoake T., Kerr D.J., et al. Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP1 alpha in vivo. Blood 79 (1992) 2221-2225
20. Graham G.J., Freshney M.G., Donaldson D., and Pragnell I.B. Purification and biochemical characterisation of human and murine stem cell inhibitors (SCI). Growth Factors 7 (1992) 151-160
21. Cocchi F., DeVico A.L., Garzino-Demo A., Arya S.K., Gallo R.C., and Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 270 (1995) 1811-1815
22. Bertini R., Luini W., Sozzani S., Bottazzi B., Ruggiero P., Boraschi D., et al. Identification of MIP-1 alpha/LD78 as a monocyte chemoattractant released by the HTLV-I-transformed cell line MT4. AIDS Res Hum Retroviruses 11 (1995) 155-160
23. Aquaro S., Menten P., Struyf S., Proost P., Van Damme J., De Clercq E., et al. The LD78beta isoform of MIP-1alpha is the most potent CC-chemokine in inhibiting CCR5-dependent human immunodeficiency virus type 1 replication in human macrophages. J Virol 75 (2001) 4402-4406
24. Hunter M.G., Bawden L., Brotherton D., Craig S., Cribbes S., Czaplewski L.G., et al. BB-10010: an active variant of human macrophage inflammatory protein-1 alpha with improved pharmaceutical properties. Blood 86 (1995) 4400-4408
25. Palermo D.P., DeGraaf M.E., Marotti K.R., Rehberg E., and Post L.E. Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression. J Biotechnol 19 (1991) 35-47
26. Lowry O., Rosebrough N., Farr A., and Randall R. Protein measurement with the Folin phenol reagent. J Biol Chem 193 (1951) 265-275
27. Grynkiewicz G., Poenie M., and Tsien R.Y. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260 (1985) 3440-3450
28. Boring L., Gosling J., Monteclaro F.S., Lusis A.J., Tsou C.L., and Charo I.F. Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9. J Biol Chem 271 (1996) 7551-7558
29. Bonini J.A., Martin S.K., Dralyuk F., Roe M.W., Philipson L.H., Steiner D.F., et al. Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. DNA Cell Biol 16 (1997) 1249-1256
30. Meyer A., Coyle A.J., Proudfoot A.E., Wells T.N., and Power C.A. Cloning and characterization of a novel murine macrophage inflammatory protein-1 alpha receptor. J Biol Chem 271 (1996) 14445-14451
31. Nibbs R.J., Wylie S.M., Pragnell I.B., and Graham G.J. Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem 272 (1997) 12495-12504
32. Nibbs R.J., Wylie S.M., Yang J., Landau N.R., and Graham G.J. Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. J Biol Chem 272 (1997) 32078-32083
33. Menten P., Struyf S., Schutyser E., Wuyts A., De Clercq E., Schols D., et al. The LD78beta isoform of MIP-1alpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine. J Clin Invest 104 (1999) R1-R5
34. Xin X., Shioda T., Kato A., Liu H., Sakai Y., and Nagai Y. Enhanced anti-HIV-1 activity of CC-chemokine LD78beta, a non-allelic variant of MIP-1alpha/LD78alpha. FEBS Lett 457 (1999) 219-222
35. Gazi L., Bobirnac I., Danzeisen M., Schupbach E., Langenegger D., Sommer B., et al. Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L-745, 870 and U-101958 at human recombinant D4. 4 receptors expressed in CHO cells. Br J Pharmacol 128 (1999) 613-620
36. Lesage A.S., Wouters R., Van Gompel P., Heylen L., Vanhoenacker P., Haegeman G., et al. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol 123 (1998) 1655-1665