A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses

European Journal of Immunology

Volumn 32, Issue 8, 2002, Pages 2124-2132

  Yang, Yi Fu ^a   Mukai, Takao ^a   Gao, Ping ^a   Yamaguchi, Nobuya ^a   Ono, Shiro ^a   Iwaki, Hiroshi ^a   Obika, Satoshi ^a   Imanishi, Takeshi ^a   Tsujimura, Takahiro ^b   Hamaoka, Toshiyuki ^a   Fujiwara, Hiromi ^a,c  

^a OSAKA UNIVERSITY   (Japan)

^b SUMITOMO HOSPITAL   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Chemokine; Chemokine receptor; IL 12; Rheumatoid arthritis; T cell migration

Indexed keywords

CHEMOKINE RECEPTOR CCR5; COLLAGEN TYPE 2; INTERLEUKIN 12; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE SEVERITY; DRUG ACTIVITY; IMMUNIZATION; INFLAMMATION; INFLAMMATORY CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE MIGRATION; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RHEUMATOID ARTHRITIS; T LYMPHOCYTE;

AMIDES; ANIMALS; ANTIBODY FORMATION; ARTHRITIS; CELL MOVEMENT; COLLAGEN; INTERLEUKIN-12; MALE; MICE; MICE, INBRED DBA; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, CCR5; T-LYMPHOCYTES;

EID: 0036687024     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200208)32:8<2124::AID-IMMU2124>3.0.CO;2-S     Document Type: Article

References (41)

1. Cellular basis for rheumatoid inflammation
2. T cell-dependent pathways in rheumatoid arthritis
3. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration
4. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
5. Lymphocyte homing and homeostasis
6. Interleukin-8 and related chemotactic cytokines - CXC and CC chemokines
7. The molecular biology of leukocyte chemoattractant receptors
8. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
9. CCR5 is characteristic of Th1 lymphocytes
10. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
11. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
12. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
13. Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils
14. + T lymphocytes into inflamed joints of rheumatoid arthritis
15. Autoimmunity to type II collagen an experimental model of arthritis
16. Immunisation against heterologous type II collagen induces arthritis in mice
17. Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist
18. Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 mice
19. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity
20. Type II collagen-induced murine arthritis. I. Induction and perpetuation of arthritis require synergy between humoral and cell-mediated immunity
21. Dual role of IL-12 in early and late stages of murine collagen type II arthritis
22. Anti-IL-12 antibody prevents the development and progression of collagen-induced arthritis in IFN-γ receptor-deficient mice
23. Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis
24. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction
25. IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones
26. + T cells
27. Chemokine expression in rheumatoid arthritis (RA): Evidence of RANTES and macrophage inflammatory protein (MIP)-1β production by synovial T cells
28. Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritis
29. Expression of the cytokine RANTES in human rheumatoid synovial fibroblasts. Differential regulation of RANTES and interleukin-8 genes by inflammatory cytokines
30. Role of T lymphocytes in collagen II induced arthritis in rats
31. + T cells through IL-12 produced by Listeria-induced macrophages
32. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming
33. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
34. Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice
35. Chemokines and their receptors in allograft rejection
36. Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells: Dependence on the release from persistent TCR-triggering and requirement for IFN-γ stimulation
37. Effect of psychological stress on the induction of arthritis in rats
38. A role of interferon-gamma (IFN-γ) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-γ-deficient mice
39. - T cell subsets to express IL-18 receptor and produce IFN-γ in response to IL-18
40. Establishment of an IL-12-responsive T cell clone: Its characterization and utilization in the quantitation of IL-12 activity
41. Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice