Interleukin-1R Signaling Is Essential for Induction of Proapoptotic CD8 T Cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice

Journal of Virology

Volumn 86, Issue 16, 2012, Pages 8713-8719

  Joeckel, Lars T ^a,b,c   Wallich, Reinhard ^d   Metkar, Sunil S ^e   Froelich, Christopher J ^e   Simon, Markus M ^a,f   Borner, Christoph ^b  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c GRK1104   (Germany)

^d UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^e NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^f NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GRANZYME; INTERLEUKIN 1 RECEPTOR; PERFORIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CELL MEDIATED CYTOTOXICITY; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE ASSOCIATION; HEPATITIS; IN VITRO STUDY; INTRACELLULAR SIGNALING; LIVER PROTECTION; LYMPHOCYTE COUNT; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPLENOMEGALY; TISSUE INJURY; VIRAL CLEARANCE;

EID: 84865081076     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00682-12     Document Type: Article

References (44)

1. Adachi O, et al. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9:143-150.
2. Afonina IS, et al. 2011. Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1 α Mol. Cell 44: 265-278.
3. +T cells. J. Neuroimmunol. 31:155-163.
4. Anthony DA, et al. 2010. A role for granzyme M in TLR4-driven inflammation and endotoxicosis. J. Immunol. 185:1794-1803.
5. Balkow S, et al. 2001. Concerted action of the FasL/Fas and perforin/ granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection. J. Virol. 75:8781-8791.
6. +T-cell population in LCMV-infected mice. J. Gen. Virol. 90:423-431.
7. Ben-Sasson SZ, et al. 2009. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc. Natl. Acad. Sci. U. S. A. 106:7119-7124.
8. Cai SF, et al. 2009. Differential expression of granzyme B and C in murine cytotoxic lymphocytes. J. Immunol. 182:6287-6297
9. +T cells. J. Immunol. 162:3256-3262.
10. Curtsinger JM, Lins DC, Johnson CM, Mescher MF. 2005. Signal 3 tolerant CD8 T cells degranulate in response to antigen but lack granzyme B to mediate cytolysis. J. Immunol. 175:4392-4399.
11. Dinarello CA. 2010. Anti-inflammatory agents: present and future. Cell 140:935-950.
12. Dinarello CA. 2009. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27:519-550.
13. Fehniger TA, et al. 2007. Acquisition of murine NK cell cytotoxicity requires the translation of a preexisting pool of granzyme B and perforin mRNAs. Immunity 26:798-811.
14. Gerber MA, Thung SN. 1985. Molecular and cellular pathology of hepatitis B. Lab. Invest. 52:572-590.
15. Grossman WJ, et al. 2004. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 21:589-601.
16. Guidotti LG, Chisari FV. 1996. To kill or to cure: options in host defense against viral infection. Curr. Opin. Immunol. 8:478-483.
17. Guidotti LG, Chisari FV. 2006. Immunobiology and pathogenesis of viral hepatitis. Annu. Rev. Pathol. 1:23-61.
18. Harris KM, Fasano A, Mann DL. 2008. Cutting edge: IL-1 controls the IL-23 response induced by gliadin, the etiologic agent in celiac disease. J. Immunol. 181:4457-4460.
19. Heusel JW, Wesselschmidt RL, Shresta S, Russell JH, Ley TJ. 1994. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76:977-987.
20. Jenkins MR, Kedzierska K, Doherty PC, Turner SJ. 2007. Heterogeneity of effector phenotype for acute phase and memory influenza A virusspecific CTL. J. Immunol. 179:64-70.
21. Joeckel LT, et al. 2011. Mouse granzyme K has proinflammatory potential. Cell Death Differ. 18:1112-1119.
22. Kägi D, et al. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31-37.
23. Kägi D, Ledermann B, Bürki K, Zinkernagel RM, Hengartner H. 1996. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu. Rev. Immunol. 14:207-232.
24. + T cells during primary activation. Int. Immunol. 14:605-613.
25. Khanolkar A, Fuller MJ, Zajac AJ. 2002. T cell responses to viral infections: lessons from lymphocytic choriomeningitis virus. Immunol. Res. 26:309-321.
26. Kurschus FC, Fellows E, Stegmann E, Jenne DE. 2008. Granzyme B delivery via perforin is restricted by size, but not by heparan sulfatedependent endocytosis. Proc. Natl. Acad. Sci. U. S. A. 105:13799-13804.
27. Lye E, Dhanji S, Calzascia T, Elford AR, Ohashi PS. 2008. IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses. Eur. J. Immunol. 38:870-876.
28. Martin P, Pardo J, Schill N, LJöckel Berg M, Froelich CJ, Wallich R, Simon MM. 2010. Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics. J. Biol. Chem. 285:18918-18927.
29. Martin P, et al. 2005. Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes? Blood 106:2871-2878.
30. Metkar SS, et al. 2008. Human and mouse granzyme A induce a proinflammatory cytokine response. Immunity 14:720-733.
31. Metkar SS, et al. 2011. Perforin rapidly induces plasma membrane phospholipid flip-flop. PLoS One 6:e24286. doi:10.1371/journal-.pone.0024286.
32. Mondelli M, Eddleston AL. 1984. Mechanisms of liver cell injury in acute and chronic hepatitis B. Semin. Liver Dis. 4:47-58.
33. Oldstone MB. 2007. A suspenseful game of "hide and seek" between virus and host. Nat. Immunol. 8:325-327.
34. Pardo J, et al. 2007. Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin. Cell Death Differ. 14:1768-1779.
35. Pardo J, et al. 2008. Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs. Cell Death Differ. 15:567-579.
36. Pardo J, Balkow S, Anel A, Simon MM. 2002. Granzymes are essential for natural killer cell-mediated and perf-facilitated tumor control. Eur. J. Immunol. 32:2881-2887.
37. Pardo J, et al. 2004. Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis. J. Cell Biol. 167:457-468.
38. Revell PA, et al. 2005. Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions. J. Immunol. 174:2124-2131.
39. Rode M, et al. 2004. Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection. J. Virol. 78:12395-12405.
40. Sims JE, Smith DE. 2010. The IL-1 family: regulators of immunity. Nat. Rev. Immunol. 10:89-102.
41. Sutton C, Brereton C, Keogh B, Mills KHG, Lavelle EC. 2006. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203:1685-1691.
42. Ward SG, Bacon K, Westwick J. 1998. Chemokines and T lymphocytes: more than an attraction. Immunity 9:1-11.
43. Zhou S, et al. 2005. MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection. Eur. J. Immunol. 35:822-830.
44. Zinkernagel RM, et al. 1986. T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay? J. Exp. Med. 164:1075-1092.