Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drug-drug interaction induced by liver metabolites

Toxicology and Applied Pharmacology

Volumn 263, Issue 2, 2012, Pages 244-250

  Nakanishi, Takeo ^a   Ikenaga, Miho ^a   Fukuda, Hajime ^a   Matsunaga, Norikazu ^a   Tamai, Ikumi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Drug drug interaction; Estradiol; Hepatic metabolism; MRP2; Sandwich culture rat hepatocyte; Transporter

Indexed keywords

BILIRUBIN; BILIRUBIN GLUCURONIDE; DICHLOROFLUORESCEIN; DRUG METABOLITE; ESTRADIOL; ESTRADIOL 17 GLUCURONIDE; MULTIDRUG RESISTANCE PROTEIN 2; VINBLASTINE;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DRUG INTERACTION; DRUG INTERACTION; FEASIBILITY STUDY; FLUORESCENCE; HYDROLYSIS; INTRACELLULAR SPACE; INTRAHEPATIC BILE DUCT; LIVER CELL; LIVER METABOLISM; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; QUANTITATIVE TIME LAPSE IMAGING; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ATP-BINDING CASSETTE TRANSPORTERS; BILIRUBIN; CELL CULTURE TECHNIQUES; DRUG INTERACTIONS; ESTRADIOL; FEASIBILITY STUDIES; FLUORESCEINS; HEPATOCYTES; MALE; RATS; RATS, WISTAR; TIME-LAPSE IMAGING; VINBLASTINE;

RATTUS;

EID: 84865075452     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.06.016     Document Type: Article

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