Modulation of hepatic canalicular or basolateral transport proteins alters hepatobiliary disposition of a model organic anion in the isolated perfused rat liver

Drug Metabolism and Disposition

Volumn 33, Issue 8, 2005, Pages 1238-1243

  Chandra, Priyamvada ^a   Johnson, Brendan M ^a   Zhang, Peijin ^b   Pollack, Gary M ^a   Brouwer, Kim L R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b Qualyst Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5(6) CARBOXY 2',7' DICHLOROFLUORESCEIN; ANION; CLOFIBRIC ACID; DEXAMETHASONE; FLUORESCEIN DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1 A 1; ORGANIC COMPOUND; PHENOBARBITAL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG ELIMINATION; EXPERIMENTAL MODEL; HEPATOBILIARY PARAMETERS; HEPATOBILIARY SYSTEM; INTRAHEPATIC BILE DUCT; ISOLATED LIVER; LIVER CELL; LIVER PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSITIVITY ANALYSIS; SIMULATION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE CANALICULI; CLOFIBRIC ACID; DEXAMETHASONE; FLUORESCEINS; FLUORESCENT DYES; HEPATOCYTES; INFUSIONS, INTRAVENOUS; LIVER; MALE; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; P-GLYCOPROTEINS; PERFUSION; PHENOBARBITAL; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR;

EID: 22944482832     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.105.003665     Document Type: Article

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