Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′- fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 17, 2012, Pages 5202-5214

  Nauš, Petr ^a   Perlíková, Pavla ^a   Bourderioux, Aurelie ^a   Pohl, Radek ^a   Slavětínská, Lenka ^a   Votruba, Ivan ^a   Bahador, Gina ^b   Birkuš, Gabriel ^b   Cihlář, Tomáš ^b   Hocek, Michal ^a,c  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b GILEAD SCIENCES   (United States)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Cytostatics; Deazapurines; Fluorine; Nucleosides; Pyrrolo 2,3 d pyrimidine

Indexed keywords

2' C METHYLRIBONUCLEOSIDE DERIVATIVE; 2' DEOXY 2' FLUOROARABINONUCLEOSIDE DERIVATIVE; 2' DEOXYRIBONUCLEOSIDE DERIVATIVE; 4 AMINO 5 (4 METHOXYPHENY) 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 5 (BENZOFURAN 2 YL) 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 5 (FURAN 2 YL) 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 5 (FURAN 2 YL) 7 (BETA DEXTRO ARABINOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 5 (FURAN 3 YL) 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 5 IODO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 5 IODO 7 (2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 5 IODO 7 (BETA DEXTRO ARABINOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 5 (NAPHTHALEN 1 YL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 5 (NAPHTHALEN 2 YL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 5 (THIOPHEN 2 YL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 5 (THIOPHEN 3 YL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 5 PHENYL 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL) 5 (1H 1,2,3 TRIAZOL 4 YL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL) 5 (1H PYRAZOL 4 YL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL) 5 (FURAN 2 YL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL) 5 (FURAN 3 YL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL) 5 (THIOPHEN 2 YL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL) 5 (THIOPHEN 3 YL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL) 5 ETHYNYL 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL) 5 PHENYL 7H PYRROLO[2,3 D]PYRIMIDINE; 4 CHLORO 5 IODO 7 (2 DEOXY 2 FLURO 3,5 DI O BENZOYL BETA DEXTRO ARABINOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 7 HETARYL 7 DEAZAADENOSINE DERIVATIVE; ADENOSINE DERIVATIVE; ARABINONUCLEOSIDE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CYTOSTASIS; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; FEMALE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; REPLICON; STILLE REACTION; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; VIRUS REPLICATION;

ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; ARABINONUCLEOSIDES; CARBOHYDRATES; DEOXYRIBONUCLEOSIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HEPACIVIRUS; HL-60 CELLS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 84864980050     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.07.003     Document Type: Article

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