Synthesis and significant cytostatic activity of 7-hetaryl-7- deazaadenosines

Journal of Medicinal Chemistry

Volumn 54, Issue 15, 2011, Pages 5498-5507

  Bourderioux, Aurelie ^a   Nauš, Petr ^a   Perlíková, Pavla ^a   Pohl, Radek ^a   Pichová, Iva ^a   Votruba, Ivan ^a   Džubák, Petr ^b   Konečný, Petr ^b   Hajdúch, Marián ^b   Stray, Kirsten M ^c   Wang, Ting ^c   Ray, Adrian S ^c   Feng, Joy Y ^c   Birkus, Gabriel ^c   Cihlar, Tomas ^c   Hocek, Michal ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b PALACKÝ UNIVERSITY   (Czech Republic)

^c GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 (2 THIENYL) 7 DEAZAADENINE RIBONUCLEOSIDE; 7 HETARYL 7 DEAZAADENOSINE DERIVATIVE; ALPHA AMANITIN; ANTINEOPLASTIC AGENT; CLADRIBINE; CLOFARABINE; DOXORUBICIN; GEMCITABINE; NUCLEOSIDE; RNA POLYMERASE II; TUBERCIDIN; TUBERCIDIN DERIVATIVE; TUBERCIDIN TRIPHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS COUPLING REACTION; CYTOSTASIS; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HEMATOPOIETIC SYSTEM TUMOR; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; RNA SYNTHESIS; SOLID TUMOR; SURVIVAL RATE;

ADENOSINE KINASE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CYTOSTATIC AGENTS; HUMANS; MICE; RNA POLYMERASE II; TUBERCIDIN;

EID: 79961212968     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2005173     Document Type: Article

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