CycloSal-phosphate pronucleotides of cytostatic 6-(het)aryl-7-deazapurine ribonucleosides: Synthesis, cytostatic activity, and inhibition of adenosine kinases

ChemMedChem

Volumn 5, Issue 8, 2010, Pages 1386-1396

  Spáčilová, Pavla ^a   Nauš, Petr ^a   Pohl, Radek ^a   Votruba, Ivan ^a   Snášel, Jan ^a   Zábranská, Helena ^a   Pichová, Iva ^a   Ameral, Ria ^b   Birkuš, Gabriel ^b   Cihlář, Tomáš ^b   Hocek, Michal ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b GILEAD SCIENCES   (United States)

Author keywords

Adenosine kinase; Nucleosides; Nucleotides; Phosphates; Prodrugs

Indexed keywords

(HET) ARYLSTANNANE DERIVATIVE; 2'3' ISOPROPYLIDENE 6 CHLORO 7 DEAZAPURINE NUCLEOSIDE; 6 HETARYL 7 DEAZAPURINE RIBONUCLEOSIDE; 7 FLUORO PRONUCLEOTIDE; ADENOSINE KINASE; BORONIC ACID DERIVATIVE; CYCLO (3 METHYLSALIGENYL) (2' 3' O ISOPROPYLIDENE BETA DEXTRO RIBOFURANOSY) 4 (3 THIENYL) 5 FLUORO 7H PYRROLO [2,3-D] PYRIMIDINE 5' PHOSPHATE; CYCLO (3 METHYLSALIGENYL) (2' 3' O ISOPROPYLIDENE BETA DEXTRO RIBOFURANOSYL 4 (2 THIENYL) 5 FLUORO 7H PYRROLO [2,3 D] PYRIMIDINE 5' PHOSPHATE; CYCLO (3 METHYLSALIGENYL) (2' 3' O ISOPROPYLIDENE BETA DEXTRO RIBOFURANOSYL 4 (4 DIBENZOFURYL) 7H PYRROLO [2,3 D] PYRIMIDINE 5' PHOSPHATE; CYCLO (3 METHYLSALIGENYL) (2' 3' O ISOPROPYLIDENE BETA DEXTRO RIBOFURANOSYL) 4 (2 BENZOFURYL) 7H PYRROLO [2,3 D] PYRIMIDINE 5' PHOSPHATE; CYCLO (3 METHYLSALIGENYL) (2' 3' O ISOPROPYLIDENE BETA DEXTRO RIBOFURANOSYL) 4 (2 FURYL) 5 FLUORO 7H PYRROLO [2,3 D] PYRIMIDINE 5' PHOSPHATE; CYCLO (3 METHYLSALIGENYL) (2' 3' O ISOPROPYLIDENE BETA DEXTRO RIBOFURANOSYL) 4 (2 FURYL) 7H PYRROLO [2,3 D] PYRIMIDINE 5' PHOSPHATE; CYCLO (3 METHYLSALIGENYL) (2' 3' O ISOPROPYLIDENE BETA DEXTRO RIBOFURANOSYL) 4 (2 THIAZOLYL) 7H PYRROLO [2,3 D] PYRIMIDINE 5' PHOSPHATE; CYCLO (3 METHYLSALIGENYL) (2' 3' O ISOPROPYLIDENE BETA DEXTRO RIBOFURANOSYL) 4 (2 THIENYL) 5 FLUORO 7H PYRROLO [2,3 D] PYRIMIDINE 5' PHOSPHATE; CYCLO (3 METHYLSALIGENYL) (2' 3' O ISOPROPYLIDENE BETA DEXTRO RIBOFURANOSYL) 4 (2 THIENYL) 7H PYRROLO [2,3 D] PYRIMIDINE 5' PHOSPHATE; CYCLO (3 METHYLSALIGENYL) (2' 3' O ISOPROPYLIDENE BETA DEXTRO RIBOFURANOSYL) 4 (3 FURYL) 5 FLUORO 7H PYRROLO [2,3 D] PYRIMIDINE 5' PHOSPHATE; CYCLO (3 METHYLSALIGENYL) (2' 3' O ISOPROPYLIDENE BETA DEXTRO RIBOFURANOSYL) 4 (3 FURYL) 7H PYRROLO [2,3 D] PYRIMIDINE 5' PHOSPHATE; CYCLO (3 METHYLSALIGENYL) (2' 3' O ISOPROPYLIDENE BETA DEXTRO RIBOFURANOSYL) 4 (3 THIENYL) 7H PYRROLO [2,3 D] PYRIMIDINE 5' PHOSPHATE; CYCLO (3 METHYLSALIGENYL) (2' 3' O ISOPROPYLIDENE BETA DEXTRO RIBOFURANOSYL) 4 [1 (N,N DIMETHYLSULFAMOYL) PYRAZOL 4 YL] 7H PYRROLO [2,3 D] PYRIMIDINE 5' PHOSPHATE; CYCLO (3 METHYLSALIGENYL) BETA D RIBOFURANOSYL 4 (2 FURYL) 7H PYRROLO [2,3 D] PYRIMIDINE 5' O PHOSPHATE; CYCLO (3 METHYLSALIGENYL) BETA DEXTRO RIBOFURANOSYL 4 (2 BENZOFURYL) 7H PYRROLO [2,3 D] PYRIMIDINE 5' O PHOSPHATE; CYCLO (3 METHYLSALIGENYL) BETA DEXTRO RIBOFURANOSYL 4 (2 THIENYL) 7H PYRROLO [2,3 D] PYRIMIDINE 5' O PHOSPHATE; CYCLO (3 METHYLSALIGENYL) BETA DEXTRO RIBOFURANOSYL 4 (3 THIENYL) 7H PYRROLO [2,3 D] PYRIMIDINE 5' O PHOSPHATE; CYCLOSAL PHOSPHATE; NEBULARINE; NUCLEOSIDE ANALOG; NUCLEOTIDE; PRODRUG; PRONUCLEOTIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STILLE REACTION; SUZUKI REACTION;

ADENOSINE KINASE; CELL LINE, TUMOR; CYTOSTATIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PHOSPHATES; PRODRUGS; PURINE NUCLEOTIDES; PURINES; RIBONUCLEOSIDES;

EID: 77955120495     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000192     Document Type: Article

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