Structure - activity relationship of heterobase-modified 2′-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication

Journal of Medicinal Chemistry

Volumn 47, Issue 21, 2004, Pages 5284-5297

  Eldrup, Anne B ^a   Prhavc, Marija ^a   Brooks, Jennifer ^a   Bhat, Balkrishen ^a   Prakash, Thazha P ^a   Song, Quanlai ^a   Bera, Sanjib ^a   Bhat, Neelima ^a   Dande, Prasad ^a   Cook, P Dan ^a   Bennett, C Frank ^a   Carroll, Steven S ^b   Ball, Richard G ^b   Bosserman, Michele ^b   Burlein, Christine ^b   Colwell, Lawrence F ^b   Fay, John F ^b   Flores, Osvaldo A ^b   Getty, Krista ^b   LaFemina, Robert L ^b   Leone, Joseph ^b   MacCoss, Malcolm ^b   McMasters, Daniel R ^b   Tomassini, Joanne E ^b   Von Langen, Derek ^b   Wolanski, Bohdan ^b   Olsen, David B ^b   more..

^a ISIS PHARMACEUTICALS   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 CHLORO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 AMINO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDIN 4(3H) ONE; 2,4 DIAMINO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 1 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 1H PYRROLO[3,2 C]PYRIDINE; 4 AMINO 2 FLUORO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 5 BROMO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 5 CHLORO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 5 FLUORO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 5 METHYL 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 1H PYRAZOLO[3,4 D]PYRIMIDINE; 4 AMINO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 7 (2 C METHYL BETA DEXTRO RIBOFURANOSYL) 7H PYRROLO[2,3 D]PYRIMIDINE 5 CARBOXYLIC ACID; RIBONUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS RNA;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME STABILITY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; MALE; NONHUMAN; RAT; RNA REPLICATION; STRUCTURE ACTIVITY RELATION;

ADENOSINE DEAMINASE; ADMINISTRATION, ORAL; ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; CELL LINE; DRUG STABILITY; HEPACIVIRUS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PHOSPHORYLATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; RATS; RIBONUCLEOSIDES; RNA, VIRAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4744364179     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040068f     Document Type: Article

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