Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 15, 2012, Pages 4801-4811

  Di Francesco, M Emilia ^a   Avolio, Salvatore ^a   Pompei, Marco ^a   Pesci, Silvia ^a   Monteagudo, Edith ^a   Pucci, Vincenzo ^a   Giuliano, Claudio ^a   Fiore, Fabrizio ^a   Rowley, Michael ^a   Summa, Vincenzo ^a  

^a IRBM   (Italy)

Author keywords

2 C methyl ribose; 7 Deaza adenine; HCV polymerase; Nucleoside inhhibitor; Nucleoside triphosphate

Indexed keywords

1,2,4 OXADIAZOLE DERIVATIVE; 2' C METHYL 2' DEOXY 2' FLUORO RIBOSE MONOPHOSPHATE; 2' C METHYL 2' DEOXY 2' FLUORO RIBOSE NUCLEOSIDE DERIVATIVE; 2' C METHYL 2' HYDROXYRIBOSE DERIVATIVE; 2' C METHYL RIBOSE MONOPHOSPHATE; 2' C METHYL RIBOSE NUCLEOSIDE DERIVATIVE; 7 HETEROCYCLIC 7 DEAZA ADENINE NUCLEOSIDE INHIBITOR; ANTIVIRUS AGENT; CARBOXYLIC ACID DERIVATIVE; NONSTRUCTURAL PROTEIN 5B; NUCLEIC ACID BASE; NUCLEOSIDE DERIVATIVE; OXADIAZOLE DERIVATIVE; OXAZOLE DERIVATIVE; PROTEIN INHIBITOR; PYRAZOLE DERIVATIVE; TETRACYCLIC 7 SUBSTITUTED 7 DEAZA ADENINE NUCLEIC ACID BASE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS C VIRUS; HYDROGEN BOND; IC 50; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RAT; REPLICON; VIRUS REPLICATION;

ANTIVIRAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HEPACIVIRUS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NUCLEOSIDES; REPLICON; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS; RATTUS;

EID: 84863983726     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.067     Document Type: Article

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