Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds

Biochemical Pharmacology

Volumn 84, Issue 6, 2012, Pages 830-837

  Zeng, Xiao Yi ^a   Zhou, Xiu ^a   Xu, Jun ^b   Chan, Stanley M H ^a   Xue, Charlie L ^a   Molero, Juan C ^a   Ye, Ji Ming ^a  

^a RMIT UNIVERSITY   (Australia)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Drug discovery; Fatty liver; Insulin resistance; Lipid accumulation; Obesity; Phenotypic screening

Indexed keywords

ALBIFLORIN; ANTIDIABETIC AGENT; BERBERINE DERIVATIVE; CHLOROFORM; FATTY ACID SYNTHASE INHIBITOR; FRUCTOSE; GENIPIN; LIPID; METHANOL EXTRACTION RESIDUE; OXYMATRINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POTASSIUM HYDROXIDE; TILIROSIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CELL STRAIN 3T3; CHINESE MEDICINE; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG SCREENING; EMBRYO; FATTY ACID SYNTHESIS; FATTY LIVER; GLUCOSE INTOLERANCE; HIGH THROUGHPUT SCREENING; IN VIVO STUDY; INSULIN RESISTANCE; LIPID DIET; LIPID STORAGE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

3T3-L1 CELLS; ADIPOSITY; ALKALOIDS; ANIMALS; ANTI-OBESITY AGENTS; BRIDGED COMPOUNDS; CELL LINE; DIETARY FATS; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; FATTY LIVER; FRUCTOSE; GLUCOSE INTOLERANCE; HIGH-THROUGHPUT SCREENING ASSAYS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; QUINOLIZINES; TRIGLYCERIDES;

EID: 84864954119     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.07.003     Document Type: Article

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