PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27 Kip1

Nucleic Acids Research

Volumn 40, Issue 14, 2012, Pages 6520-6533

  Pérez Luna, Maria ^a   Aguasca, Marta ^a   Perearnau, Anna ^a   Serratosa, Joan ^b   Martínez Balbas, Marian ^c   Jesús Pujol, Maria ^a   Bachs, Oriol ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INST D INVESTIGACIONS B   (Spain)

^c INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; HISTONE ACETYLTRANSFERASE PCAF;

ACETYLATION; AFFINITY CHROMATOGRAPHY; ARTICLE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

ACETYLATION; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P27; HEK293 CELLS; HELA CELLS; HUMANS; LYSINE; P300-CBP TRANSCRIPTION FACTORS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STABILITY;

EID: 84864950417     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks343     Document Type: Article

References (44)

1. Morgan, D.O. (1997) Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol., 13, 261-291. (Pubitemid 28034527)
2. Malumbres, M. and Barbacid, M. (2005) Mammalian cyclin-dependent kinases. Trends Biochem. Sci., 30, 630-641. (Pubitemid 41540083)
3. Paternot, S., Bockstaele, L., Bisteau, X., Kooken, H., Coulonval, K. and Roger, P.P. (2010) Rb inactivation in cell cycle and cancer: the puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase. Cell Cycle, 9, 689-699.
4. Blais, A. and Dynlacht, B.D. (2007) E2F-associated chromatin modifiers and cell cycle control. Curr. Opin. Cell Biol., 19, 658-662. (Pubitemid 350216425)
5. Besson, A., Dowdy, S.F. and Roberts, J.M. (2008) CDK inhibitors: cell cycle regulators and beyond. Dev. Cell, 14, 159-169. (Pubitemid 351189186)
6. Mateo, F., Vidal-Laliena, M., Canela, N., Zecchin, A., Martinez-Balbas, M., Agell, N., Giacca, M., Pujol, M.J. and Bachs, O. (2009) The transcriptional co-activator PCAF regulates cdk2 activity. Nucleic Acids Res., 37, 7072-7084.
7. Echalier, A., Endicott, J.A. and Noble, M.E. (2010) Recent developments in cyclin-dependent kinase biochemical and structural studies. Biochim. Biophys. Acta, 1804, 511-519.
8. Sherr, C.J. and Roberts, J.M. (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev., 13, 1501-1512. (Pubitemid 29297917)
9. Porter, P.L., Malone, K.E., Heagerty, P.J., Alexander, G.M., Gatti, L.A., Firpo, E.J., Daling, J.R. and Roberts, J.M. (1997) Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat. Med., 3, 222-225. (Pubitemid 27064709)
10. Chu, I.M., Hengst, L. and Slingerland, J.M. (2008) The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat. Rev. Cancer, 8, 253-267. (Pubitemid 351430863)
11. Slingerland, J. and Pagano, M. (2000) Regulation of the cdk inhibitor p27 and its deregulation in cancer. J. Cell Physiol., 183, 10-17. (Pubitemid 30130220)
12. Pagano, M., Tam, S.W., Theodoras, A.M., Beer-Romero, P., Del Sal, G., Chau, V., Yew, P.R., Draetta, G.F. and Rolfe, M. (1995) Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science, 269, 682-685.
13. Catzavelos, C., Bhattacharya, N., Ung, Y.C., Wilson, J.A., Roncari, L., Sandhu, C., Shaw, P., Yeger, H., Morava-Protzner, I., Kapusta, L. et al. (1997) Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer. Nat. Med., 3, 227-230. (Pubitemid 27064710)
14. Belletti, B., Nicoloso, M.S., Schiappacassi, M., Chimienti, E., Berton, S., Lovat, F., Colombatti, A. and Baldassarre, G. (2005) p27(kip1) functional regulation in human cancer: a potential target for therapeutic designs. Curr. Med. Chem., 12, 1589-1605. (Pubitemid 40895003)
15. Fero, M.L., Rivkin, M., Tasch, M., Porter, P., Carow, C.E., Firpo, E., Polyak, K., Tsai, L.H., Broudy, V., Perlmutter, R.M. et al. (1996) A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell, 85, 733-744.
16. Kiyokawa, H., Kineman, R.D., Manova-Todorova, K.O., Soares, V.C., Hoffman, E.S., Ono, M., Khanam, D., Hayday, A.C., Frohman, L.A. and Koff, A. (1996) Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell, 85, 721-732.
17. Fero, M.L., Randel, E., Gurley, K.E., Roberts, J.M. and Kemp, C.J. (1998) The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature, 396, 177-180. (Pubitemid 28523620)
18. Besson, A., Hwang, H.C., Cicero, S., Donovan, S.L., Gurian-West, M., Johnson, D., Clurman, B.E., Dyer, M.A. and Roberts, J.M. (2007) Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev., 21, 1731-1746. (Pubitemid 47076473)
19. Pippa, R., Espinosa, L., Gundem, G., Garcia-Escudero, R., Dominguez, A., Orlando, S., Gallastegui, E., Saiz, C., Besson, A., Pujol, M.J. et al. (2011) p27(Kip1) represses transcription by direct interaction with p130/E2F4 at the promoters of target genes. Oncogene, December 19 (doi:10.1038/onc.2011.582; epub ahead of print).
20. Santos-Rosa, H., Valls, E., Kouzarides, T. and Martinez-Balbas, M. (2003) Mechanisms of P/CAF auto-acetylation. Nucleic Acids Res., 31, 4285-4292. (Pubitemid 37441789)
21. Estanyol, J.M., Jaumot, M., Casanovas, O., Rodriguez-Vilarrupla, A., Agell, N. and Bachs, O. (1999) The protein SET regulates the inhibitory effect of p21(Cip1) on cyclin E-cyclindependent kinase 2 activity. J. Biol. Chem., 274, 33161-33165. (Pubitemid 129535360)
22. Martinez-Balbas, M.A., Bannister, A.J., Martin, K., Haus-Seuffert, P., Meisterernst, M. and Kouzarides, T. (1998) The acetyltransferase activity of CBP stimulates transcription. EMBO J., 17, 2886-2893.
23. Bannister, A.J. and Kouzarides, T. (1996) The CBP co-activator is a histone acetyltransferase. Nature, 384, 641-643. (Pubitemid 27021517)
24. Canela, N., Rodriguez-Vilarrupla, A., Estanyol, J.M., Diaz, C., Pujol, M.J., Agell, N. and Bachs, O. (2003) The SET protein regulates G2/M transition by modulating cyclin B-cyclindependent kinase 1 activity. J. Biol. Chem., 278, 1158-1164. (Pubitemid 36790797)
25. Kossatz, U., Dietrich, N., Zender, L., Buer, J., Manns, M.P. and Malek, N.P. (2004) Skp2-dependent degradation of p27kip1 is essential for cell cycle progression. Genes Dev., 18, 2602-2607. (Pubitemid 39453099)
26. Blanco-Garcia, N., Asensio-Juan, E., de la Cruz, X. and Martinez-Balbas, M.A. (2009) Autoacetylation regulates P/CAF nuclear localization. J. Biol. Chem., 284, 1343-1352.
27. Sugiyama, Y., Tomoda, K., Tanaka, T., Arata, Y., Yoneda-Kato, N. and Kato, J. (2001) Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1. J. Biol. Chem., 276, 12084-12090.
28. Poux, A.N., Cebrat, M., Kim, C.M., Cole, P.A. and Marmorstein, R. (2002) Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor. Proc. Natl Acad. Sci. USA, 99, 14065-14070. (Pubitemid 35257625)
29. Schuetz, A., Bernstein, G., Dong, A., Antoshenko, T., Wu, H., Loppnau, P., Bochkarev, A. and Plotnikov, A.N. (2007) Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A. Proteins, 68, 403-407. (Pubitemid 46871613)
30. Mateo, F., Vidal-Laliena, M., Canela, N., Busino, L., Martinez-Balbas, M.A., Pagano, M., Agell, N. and Bachs, O. (2009) Degradation of cyclin A is regulated by acetylation. Oncogene, 28, 2654-2666.
31. Nakayama, K.I. and Nakayama, K. (2005) Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin. Cell Dev. Biol., 16, 323-333.
32. Kamura, T., Hara, T., Matsumoto, M., Ishida, N., Okumura, F., Hatakeyama, S., Yoshida, M., Nakayama, K. and Nakayama, K.I. (2004) Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat. Cell Biol., 6, 1229-1235. (Pubitemid 39625122)
33. Kotoshiba, S., Kamura, T., Hara, T., Ishida, N. and Nakayama, K.I. (2005) Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase. J. Biol. Chem., 280, 17694-17700. (Pubitemid 41389006)
34. Malek, N.P., Sundberg, H., McGrew, S., Nakayama, K., Kyriakides, T.R., Roberts, J.M. and Kyriakidis, T.R. (2001) A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature, 413, 323-327. (Pubitemid 32905854)
35. Hara, T., Kamura, T., Nakayama, K., Oshikawa, K., Hatakeyama, S. and Nakayama, K. (2001) Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway. J. Biol. Chem., 276, 48937-48943.
36. Grimmler, M., Wang, Y., Mund, T., Cilensek, Z., Keidel, E.M., Waddell, M.B., Jakel, H., Kullmann, M., Kriwacki, R.W. and Hengst, L. (2007) Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell, 128, 269-280. (Pubitemid 46123508)
37. Chu, I., Sun, J., Arnaout, A., Kahn, H., Hanna, W., Narod, S., Sun, P., Tan, C.K., Hengst, L. and Slingerland, J. (2007) p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell, 128, 281-294. (Pubitemid 46123510)
38. Mayer, B.J. (2001) SH3 domains: complexity in moderation. J. Cell Sci., 114, 1253-1263. (Pubitemid 32409462)
39. Borriello, A., Cucciolla, V., Oliva, A., Zappia, V. and Della, R.F. (2007) p27Kip1 metabolism: a fascinating labyrinth. Cell Cycle, 6, 1053-1061.
40. Kinoshita, T., Miyano, N., Nakai, R., Yokota, K., Ishiguro, H. and Tada, T. (2008) Protein purification and preliminary crystallographic analysis of human Lyn tyrosine kinase. Protein Expr. Purif., 58, 318-324.
41. Vervoorts, J. and Luscher, B. (2008) Post-translational regulation of the tumor suppressor p27(KIP1). Cell Mol. Life Sci., 65, 3255-3264.
42. Miranda-Carboni, G.A., Krum, S.A., Yee, K., Nava, M., Deng, Q.E., Pervin, S., Collado-Hidalgo, A., Galic, Z., Zack, J.A., Nakayama, K. et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev., 22, 3121-3134.
43. Tsihlias, J., Kapusta, L. and Slingerland, J. (1999) The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. Annu. Rev. Med., 50, 401-423. (Pubitemid 29117075)
44. Blain, S.W., Scher, H.I., Cordon-Cardo, C. and Koff, A. (2003) p27 as a target for cancer therapeutics. Cancer Cell, 3, 111-115. (Pubitemid 37443384)