Determination of oxyntomodulin, an anorectic polypeptide, in rat plasma using 2D-LC-MS/MS coupled with ion pair chromatography

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 903, Issue , 2012, Pages 102-111

  Halquist, Matthew S ^a   Sakagami, Masahiro ^a   Karnes, H Thomas ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Ion pair; LC MS MS; Multiply charged; Plasma; Polypeptide; Two dimensional liquid chromatography

Indexed keywords

2D-LC-MS/MS; ANION EXCHANGE; CHARGE STATE; INTERNAL STANDARDS; ION PAIRS; ION-PAIR CHROMATOGRAPHY; LC-MS/MS; LINEAR RANGE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTIFICATIONS; MIXED MODE; MOBILE PHASE ADDITIVES; MULTIPLY CHARGED; RAT PLASMA; REVERSED PHASE; RUNTIMES; SOLID PHASE EXTRACTION METHOD; STRUCTURAL SIMILARITY; TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY;

ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMAS; POLYPEPTIDES; PROTEINS; TWO DIMENSIONAL;

BODY FLUIDS;

ANOREXIGENIC AGENT; OXYNTOMODULIN;

ACCURACY; ARTICLE; CONTROLLED STUDY; ION PAIR CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; VALIDATION STUDY;

ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; LINEAR MODELS; OXYNTOMODULIN; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84864942408     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.06.047     Document Type: Article

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