Liquid chromatography method for determination of bivalirudin in human plasma and urine using automated ortho-phthalaldehyde derivatization and fluorescence detection

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 802, Issue 2, 2004, Pages 355-359

  Farthing, Don ^a   Larus, Terri ^a   Fakhry, Itaf ^a   Gehr, Todd ^a   Prats, Jayne ^b   Sica, Domenic ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Medicines Company   (United States)

Author keywords

Bivalirudin; Derivatization, LC

Indexed keywords

BIOMEDICAL ENGINEERING; FLUORESCENCE; ORGANIC ACIDS; PATIENT TREATMENT; PHARMACOKINETICS;

HUMAN PLASMA; URINE;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

HIRULOG; METHANOL; PHTHALALDEHYDE; TRIFLUOROACETIC ACID; WATER;

ANALYTIC METHOD; AQUEOUS SOLUTION; ARTICLE; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG URINE LEVEL; FLOW RATE; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; PERCUTANEOUS CORONARY INTERVENTION; PHASE TRANSITION; PRIORITY JOURNAL; SOLID PHASE EXTRACTION;

EID: 1342285639     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2003.12.003     Document Type: Article

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