Trace LC/MS quantitative analysis of polypeptide biomarkers: Impact of 1-D and 2-D chromatography on matrix effects and sensitivity

Journal of Separation Science

Volumn 30, Issue 2, 2007, Pages 226-233

  Rogatsky, Eduard ^a   Tomuta, Vlad ^a   Jayatillake, Harsha ^a   Cruikshank, Greg ^a   Vele, Louis ^a   Stein, Daniel T ^a  

^a YESHIVA UNIVERSITY   (United States)

Author keywords

C peptide; Column switching; Ionization efficiency; Mass spectrometry; Matrix effects

Indexed keywords

BIOCHEMISTRY; BIOMARKERS; CHEMICAL ANALYSIS; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; POLYPEPTIDES;

BIOLOGICAL SAMPLES; IONIZATION EFFICIENCY; POLYPEPTIDE BIOMARKERS;

PLASMA (HUMAN);

C PEPTIDE; PEPTIDE HORMONE; POLYPEPTIDE;

ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; HORMONE DETERMINATION; HUMAN; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN DETERMINATION; QUALITY CONTROL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE;

BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; GLUCAGON; HUMANS; PEPTIDES; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 33847277872     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200600250     Document Type: Article

References (20)

1. Taylor, P. J., Clin. Biochem. 2005, 38, 328-334.
2. Annesley, T. M., Clin. Chem. 2003, 49, 1041.
3. Antignac, J.-P., Wasch, K., Monteau, F., Brabander, H., et al., Anal. Clin. Acta 2005, 529, 129-136.
4. King, R., Bonfiglio, R., Fernandez-Metzler, C., Miller-Stein, C., Olah, T., J. Am. Soc. Mass Spectrom. 2000, 11, 942-950.
5. Dams, R., Huestis, M., Lambert, W., Murphy, C., J. Am. Soc. Mass Spectrom. 2003, 14, 1290-1294.
6. Bonfiglio, R., King, R., Olah, T., Merkle, K., Rapid Commun. Mass Spectrom. 1999, 13, 1175-1185.
7. Hu, X., Lan, J., Korfmacher, W., Anal. Chem. A-Pages 2005, 77, 389-394.
8. McGarry, J. D., Science 1992, 258, 766-770.
9. Raskin, P., Unger, R. H., Med. Clin. North Am. 1978, 62, 713-722.
10. Rogatsky, E., Tomuta, V., Cruikshank, G., Vele, L., et al., J. Sep. Sci. 2006, 29, 529-537.
11. Rogatsky, E., Stein, D., J. Sep. Sci. 2006, 29, 538-546.
12. Rogatsky, E., Balent, B., Goswami, G., Tomuta, V., Stein, D. T., Clin. Chem. 2006, 52, 872-879.
13. Hillestrøm, P. R., Weimann, A., Poulsen, H. E., J. Am. Soc. Mass Spectrom. 2006, 17, 605-610.
14. Pascoe, R., Foley, J. P., Gusev, A. I., Anal. Chem. 2001, 73, 6014-6023.
15. Rogatsky, E., Stein, D., J. Am. Soc. Mass Spectrom. 2005, 16, 1757-1759.
16. Fierens, C., Thienpont, L., Stöckl, D., Willekens, E., Leenheer, A., J. Chromatogr. A 2000, 896, 275-278.
17. Darby, S., Miller, M., Allen, R., LeBeau, M., J. Anal. Toxicol. 2001, 25, 8-14.
18. Weng, T., Matrix effects beyond LC-MS/MS - stable labeled internal standards may not be you savior. Lecture at 53rd Conference of American Society of Mass Spectrometry, June 2005, San Antonio, TX, USA.
19. Jemal, M., Shuster, A., Whigan, D. B., Rapid Commun. Mass Spectrom. 2003, 17, 1723-1734.
20. Delinsky, D., Hill, K., White, C., Bartlett, M., Biomed. Chromatogr. 2004, 18, 700-705.