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Volumn 49, Issue 4, 2012, Pages 277-289

Molecular mechanisms of muscarinic acetylcholine receptor-stimulated increase in cytosolic free Ca2+ concentration and ERK1/2 activation in the MIN6 pancreatic b-cell line

Author keywords

Acetylcholine; B cell; Calcium; Carbachol; Extracellular signal regulated kinase; Islet; Muscarinic acetylcholine receptor

Indexed keywords

CALCIUM; CALCIUM CHANNEL L TYPE; MITOGEN ACTIVATED PROTEIN KINASE 1; MUSCARINIC RECEPTOR; PHOSPHOLIPASE C BETA; PROTEIN KINASE C;

EID: 84864942269     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-011-0314-9     Document Type: Article
Times cited : (11)

References (54)
  • 1
    • 0034001450 scopus 로고    scopus 로고
    • Autonomic regulation of islet hormone secretion- implications for health and disease
    • Ahren B (2000) Autonomic regulation of islet hormone secretion- implications for health and disease. Diabetologia 43(4): 393-410
    • (2000) Diabetologia , vol.43 , Issue.4 , pp. 393-410
    • Ahren, B.1
  • 2
    • 0034786750 scopus 로고    scopus 로고
    • Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function
    • Gilon P, Henquin JC (2001) Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function. Endocr Rev 22(5):565-604
    • (2001) Endocr Rev , vol.22 , Issue.5 , pp. 565-604
    • Gilon, P.1    Henquin, J.C.2
  • 3
    • 33744510095 scopus 로고    scopus 로고
    • A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo
    • doi:10.1016/j.cmet.2006.04.009
    • Gautam D, Han SJ, Hamdan FF, Jeon J, Li B, Li JH, Cui Y, Mears D, Lu H, Deng C, Heard T, Wess J (2006) A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab 3(6):449-461. doi:10.1016/j.cmet.2006.04.009
    • (2006) Cell Metab , vol.3 , Issue.6 , pp. 449-461
    • Gautam, D.1    Han, S.J.2    Hamdan, F.F.3    Jeon, J.4    Li, B.5    Li, J.H.6    Cui, Y.7    Mears, D.8    Lu, H.9    Deng, C.10    Heard, T.11    Wess, J.12
  • 4
    • 80052388638 scopus 로고    scopus 로고
    • Impaired early-but not late-phase insulin secretion in subjects with impaired fasting glucose
    • doi:10.1007/s00592-011-0285-x
    • Kanat M, Norton L, Winnier D, Jenkinson C, Defronzo RA, Abdul-Ghani MA Impaired early-but not late-phase insulin secretion in subjects with impaired fasting glucose. Acta Diabetol. doi:10.1007/s00592-011-0285-x
    • Acta Diabetol
    • Kanat, M.1    Norton, L.2    Winnier, D.3    Jenkinson, C.4    Defronzo, R.A.5    Abdul-Ghani, M.A.6
  • 5
    • 33744506842 scopus 로고    scopus 로고
    • Ringing the dinner bell for insulin: Muscarinic M3 receptor activity in the control of pancreatic beta cell function
    • doi:10.1016/j.cmet.2006. 05.004
    • Gromada J, Hughes TE (2006) Ringing the dinner bell for insulin: muscarinic M3 receptor activity in the control of pancreatic beta cell function. Cell Metab 3(6):390-392. doi:10.1016/j.cmet.2006. 05.004
    • (2006) Cell Metab , vol.3 , Issue.6 , pp. 390-392
    • Gromada, J.1    Hughes, T.E.2
  • 6
    • 0034007213 scopus 로고    scopus 로고
    • Quantitative and functional characterization of muscarinic receptor subtypes in insulin-secreting cell lines and rat pancreatic islets
    • Iismaa TP, Kerr EA, Wilson JR, Carpenter L, Sims N, Biden TJ (2000) Quantitative and functional characterization of muscarinic receptor subtypes in insulin-secreting cell lines and rat pancreatic islets. Diabetes 49(3):392-398
    • (2000) Diabetes , vol.49 , Issue.3 , pp. 392-398
    • Iismaa, T.P.1    Kerr, E.A.2    Wilson, J.R.3    Carpenter, L.4    Sims, N.5    Biden, T.J.6
  • 7
    • 15144355308 scopus 로고    scopus 로고
    • Identification of muscarinic receptor subtypes in RINm5F cells by means of polymerase chain reaction, subcloning, and DNA sequencing
    • Tang SH, Sharp GW (1997) Identification of muscarinic receptor subtypes in RINm5F cells by means of polymerase chain reaction, subcloning, and DNA sequencing. Diabetes 46(9):1419-1423
    • (1997) Diabetes , vol.46 , Issue.9 , pp. 1419-1423
    • Tang, S.H.1    Sharp, G.W.2
  • 8
    • 0028912766 scopus 로고
    • Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors
    • Boschero AC, Szpak-Glasman M, Carneiro EM, Bordin S, Paul I, Rojas E, Atwater I (1995) Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors. Am J Physiol 268 (2 Pt 1):E336-E342
    • (1995) Am J Physiol , vol.268 , Issue.1 PART 1
    • Boschero, A.C.1    Szpak-Glasman, M.2    Carneiro, E.M.3    Bordin, S.4    Paul, I.5    Rojas, E.6    Atwater, I.7
  • 10
    • 0024472059 scopus 로고
    • New subtypes of muscarinic acetylcholine receptors
    • Bonner TI (1989) New subtypes of muscarinic acetylcholine receptors. Trends Pharmacol Sci 10(Suppl):11-15
    • (1989) Trends Pharmacol Sci , vol.10 , Issue.SUPPL. , pp. 11-15
    • Bonner, T.I.1
  • 11
    • 0033555253 scopus 로고    scopus 로고
    • Signalling pathway leading to an activation of mitogenactivated protein kinase by stimulating M3 muscarinic receptor
    • Kim JY, Yang MS, Oh CD, Kim KT, Ha MJ, Kang SS, Chun JS (1999) Signalling pathway leading to an activation of mitogenactivated protein kinase by stimulating M3 muscarinic receptor. Biochem J 337(Pt 2):275-280
    • (1999) Biochem J 337 , Issue.PART 2 , pp. 275-280
    • Kim, J.Y.1    Yang, M.S.2    Oh, C.D.3    Kim, K.T.4    Ha, M.J.5    Kang, S.S.6    Chun, J.S.7
  • 12
    • 0033559333 scopus 로고    scopus 로고
    • Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors
    • Wylie PG, Challiss RA, Blank JL (1999) Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors. Biochem J 338(Pt 3):619-628
    • (1999) Biochem J , vol.338 , Issue.PART 3 , pp. 619-628
    • Wylie, P.G.1    Challiss, R.A.2    Blank, J.L.3
  • 13
    • 0034882143 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase by muscarinic receptors in astroglial cells: Role in DNA synthesis and effect of ethanol
    • Yagle K, Lu H, Guizzetti M, Moller T, Costa LG (2001) Activation of mitogen-activated protein kinase by muscarinic receptors in astroglial cells: role in DNA synthesis and effect of ethanol. Glia 35(2):111-120
    • (2001) Glia , vol.35 , Issue.2 , pp. 111-120
    • Yagle, K.1    Lu, H.2    Guizzetti, M.3    Moller, T.4    Costa, L.G.5
  • 15
    • 37249074327 scopus 로고    scopus 로고
    • The protein kinases ERK1/2 and their roles in pancreatic beta cells
    • doi:10.1111/j.1748-1716. 2007.01785.x
    • Lawrence M, Shao C, Duan L, McGlynn K, Cobb MH (2008) The protein kinases ERK1/2 and their roles in pancreatic beta cells. Acta Physiol (Oxf) 192(1):11-17. doi:10.1111/j.1748-1716. 2007.01785.x
    • (2008) Acta Physiol (Oxf) , vol.192 , Issue.1 , pp. 11-17
    • Lawrence, M.1    Shao, C.2    Duan, L.3    McGlynn, K.4    Cobb, M.H.5
  • 16
    • 33749344947 scopus 로고    scopus 로고
    • ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: A key role in glucose-mediated pancreatic beta-cell survival
    • Costes S, Broca C, Bertrand G, Lajoix AD, Bataille D, Bockaert J, Dalle S (2006) ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: a key role in glucose-mediated pancreatic beta-cell survival. Diabetes 55(8): 2220-2230
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2220-2230
    • Costes, S.1    Broca, C.2    Bertrand, G.3    Lajoix, A.D.4    Bataille, D.5    Bockaert, J.6    Dalle, S.7
  • 17
    • 33645239679 scopus 로고    scopus 로고
    • Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways
    • Friedrichsen BN, Neubauer N, Lee YC, Gram VK, Blume N, Petersen JS, Nielsen JH, Moldrup A (2006) Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways. J Endocrinol 188(3):481-492
    • (2006) J Endocrinol , vol.188 , Issue.3 , pp. 481-492
    • Friedrichsen, B.N.1    Neubauer, N.2    Lee, Y.C.3    Gram, V.K.4    Blume, N.5    Petersen, J.S.6    Nielsen, J.H.7    Moldrup, A.8
  • 18
    • 12344265667 scopus 로고    scopus 로고
    • Extracellularly regulated kinases 1/2 (p44/42 mitogenactivated protein kinases) phosphorylate synapsin i and regulate insulin secretion in the MIN6 beta-cell line and islets of Langerhans
    • Longuet C, Broca C, Costes S, Hani EH, Bataille D, Dalle S (2005) Extracellularly regulated kinases 1/2 (p44/42 mitogenactivated protein kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 beta-cell line and islets of Langerhans. Endocrinology 146(2):643-654
    • (2005) Endocrinology , vol.146 , Issue.2 , pp. 643-654
    • Longuet, C.1    Broca, C.2    Costes, S.3    Hani, E.H.4    Bataille, D.5    Dalle, S.6
  • 19
    • 41149118021 scopus 로고    scopus 로고
    • A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic beta-cells
    • Gomez E, Powell ML, Bevington A, Herbert TP (2008) A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic beta-cells. Biochem J 410(3):485-493
    • (2008) Biochem J , vol.410 , Issue.3 , pp. 485-493
    • Gomez, E.1    Powell, M.L.2    Bevington, A.3    Herbert, T.P.4
  • 20
    • 10644234677 scopus 로고    scopus 로고
    • Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor
    • Palmer AE, Jin C, Reed JC, Tsien RY (2004) Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor. Proc Natl Acad Sci USA 101(50):17404-17409
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.50 , pp. 17404-17409
    • Palmer, A.E.1    Jin, C.2    Reed, J.C.3    Tsien, R.Y.4
  • 21
    • 0037799269 scopus 로고    scopus 로고
    • Protein kinase C isoform-specific differences in the spatial-temporal regulation and decoding of metabotropic glutamate receptor1a-stimulated second messenger responses
    • Babwah AV, Dale LB, Ferguson SS (2003) Protein kinase C isoform-specific differences in the spatial-temporal regulation and decoding of metabotropic glutamate receptor1a-stimulated second messenger responses. J Biol Chem 278(7):5419-5426
    • (2003) J Biol Chem , vol.278 , Issue.7 , pp. 5419-5426
    • Babwah, A.V.1    Dale, L.B.2    Ferguson, S.S.3
  • 22
    • 0031014997 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of dominant negative ras(asn17) in 3T3L1 adipocytes does not alter insulin-stimulated P13-kinase activity or glucose transport
    • Gnudi L, Frevert EU, Houseknecht KL, Erhardt P, Kahn BB (1997) Adenovirus-mediated gene transfer of dominant negative ras(asn17) in 3T3L1 adipocytes does not alter insulin-stimulated P13-kinase activity or glucose transport. Mol Endocrinol 11(1):67-76
    • (1997) Mol Endocrinol , vol.11 , Issue.1 , pp. 67-76
    • Gnudi, L.1    Frevert, E.U.2    Houseknecht, K.L.3    Erhardt, P.4    Kahn, B.B.5
  • 23
    • 0037073717 scopus 로고    scopus 로고
    • CAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells
    • Gomez E, Pritchard C, Herbert TP (2002) cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells. J Biol Chem 277(50):48146-48151
    • (2002) J Biol Chem , vol.277 , Issue.50 , pp. 48146-48151
    • Gomez, E.1    Pritchard, C.2    Herbert, T.P.3
  • 24
    • 65649090185 scopus 로고    scopus 로고
    • Identification of cAMP-dependent kinase as a third in vivo ribosomal protein S6 kinase in pancreatic beta-cells
    • Moore CE, Xie J, Gomez E, Herbert TP (2009) Identification of cAMP-dependent kinase as a third in vivo ribosomal protein S6 kinase in pancreatic beta-cells. J Mol Biol 389(3):480-494
    • (2009) J Mol Biol , vol.389 , Issue.3 , pp. 480-494
    • Moore, C.E.1    Xie, J.2    Gomez, E.3    Herbert, T.P.4
  • 25
    • 0032570702 scopus 로고    scopus 로고
    • Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells
    • Willars GB, Nahorski SR, Challiss RA (1998) Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells. J Biol Chem 273(9):5037-5046
    • (1998) J Biol Chem , vol.273 , Issue.9 , pp. 5037-5046
    • Willars, G.B.1    Nahorski, S.R.2    Challiss, R.A.3
  • 26
    • 0021750054 scopus 로고
    • Inositol trisphosphate, a novel second messenger in cellular signal transduction
    • Berridge MJ, Irvine RF (1984) Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312(5992):315-321
    • (1984) Nature , vol.312 , Issue.5992 , pp. 315-321
    • Berridge, M.J.1    Irvine, R.F.2
  • 27
    • 0031907117 scopus 로고    scopus 로고
    • Activation of protein kinase C triggers its ubiquitination and degradation
    • Lu Z, Liu D, Hornia A, Devonish W, Pagano M, Foster DA (1998) Activation of protein kinase C triggers its ubiquitination and degradation. Mol Cell Biol 18(2):839-845
    • (1998) Mol Cell Biol , vol.18 , Issue.2 , pp. 839-845
    • Lu, Z.1    Liu, D.2    Hornia, A.3    Devonish, W.4    Pagano, M.5    Foster, D.A.6
  • 28
    • 0027248964 scopus 로고
    • Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
    • Wilkinson SE, Parker PJ, Nixon JS (1993) Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J 294(Pt 2):335-337
    • (1993) Biochem J , vol.294 , Issue.PART 2 , pp. 335-337
    • Wilkinson, S.E.1    Parker, P.J.2    Nixon, J.S.3
  • 31
    • 0035133762 scopus 로고    scopus 로고
    • 2-Aminoethoxydiphenyl borate affects the inositol 1, 4, 5-trisphosphate receptor, the intracellular Ca2+ pump and the nonspecific Ca2+ leak from the non-mitochondrial Ca2+ stores in permeabilized A7r5 cells
    • doi: 10.1054/ceca.2000.0163
    • Missiaen L, Callewaert G, De Smedt H, Parys JB (2001) 2-Aminoethoxydiphenyl borate affects the inositol 1, 4, 5-trisphosphate receptor, the intracellular Ca2+ pump and the nonspecific Ca2+ leak from the non-mitochondrial Ca2+ stores in permeabilized A7r5 cells. Cell Calcium 29(2):111-116. doi: 10.1054/ceca.2000.0163
    • (2001) Cell Calcium , vol.29 , Issue.2 , pp. 111-116
    • Missiaen, L.1    Callewaert, G.2    De Smedt, H.3    Parys, J.B.4
  • 32
    • 0023923543 scopus 로고
    • Muscarinic control of pancreatic B cell function involves sodium-dependent depolarization and calcium influx
    • Henquin JC, Garcia MC, Bozem M, Hermans MP, Nenquin M (1988) Muscarinic control of pancreatic B cell function involves sodium-dependent depolarization and calcium influx. Endocrinology 122(5):2134-2142
    • (1988) Endocrinology , vol.122 , Issue.5 , pp. 2134-2142
    • Henquin, J.C.1    Garcia, M.C.2    Bozem, M.3    Hermans, M.P.4    Nenquin, M.5
  • 33
    • 0032491439 scopus 로고    scopus 로고
    • Membrane phospholipid control of nucleotide sensitivity of KATP channels
    • Shyng SL, Nichols CG (1998) Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science 282(5391): 1138-1141
    • (1998) Science , vol.282 , Issue.5391 , pp. 1138-1141
    • Shyng, S.L.1    Nichols, C.G.2
  • 34
    • 0036155789 scopus 로고    scopus 로고
    • Intracellular Ca2+ modulation of ATP-sensitive K(+) channel activity in acetylcholine-induced activation of rat pancreatic beta-cells
    • Nakano K, Suga S, Takeo T, Ogawa Y, Suda T, Kanno T, Wakui M (2002) Intracellular Ca2+ modulation of ATP-sensitive K(+) channel activity in acetylcholine-induced activation of rat pancreatic beta-cells. Endocrinology 143(2):569-576
    • (2002) Endocrinology , vol.143 , Issue.2 , pp. 569-576
    • Nakano, K.1    Suga, S.2    Takeo, T.3    Ogawa, Y.4    Suda, T.5    Kanno, T.6    Wakui, M.7
  • 35
    • 25844434827 scopus 로고    scopus 로고
    • Membrane phosphoinositides control insulin secretion through their effects on ATP-sensitive K + channel activity
    • Lin CW, Yan F, Shimamura S, Barg S, Shyng SL (2005) Membrane phosphoinositides control insulin secretion through their effects on ATP-sensitive K + channel activity. Diabetes 54(10):2852-2858
    • (2005) Diabetes , vol.54 , Issue.10 , pp. 2852-2858
    • Lin, C.W.1    Yan, F.2    Shimamura, S.3    Barg, S.4    Shyng, S.L.5
  • 37
    • 0033612242 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of inositol 1, 4, 5-trisphosphate that underlies complex Ca2+ mobilization patterns
    • Hirose K, Kadowaki S, Tanabe M, Takeshima H, Iino M (1999) Spatiotemporal dynamics of inositol 1, 4, 5-trisphosphate that underlies complex Ca2+ mobilization patterns. Science 284(5419):1527-1530
    • (1999) Science , vol.284 , Issue.5419 , pp. 1527-1530
    • Hirose, K.1    Kadowaki, S.2    Tanabe, M.3    Takeshima, H.4    Iino, M.5
  • 38
    • 0035960037 scopus 로고    scopus 로고
    • Intracellular signaling.Receptor-specific messenger oscillations
    • doi:10.1038/35096643
    • Nash MS, Young KW, Challiss RA, Nahorski SR (2001) Intracellular signalling. Receptor-specific messenger oscillations. Nature 413(6854):381-382. doi:10.1038/35096643
    • (2001) Nature , vol.413 , Issue.6854 , pp. 381-382
    • Nash, M.S.1    Young, K.W.2    Challiss, R.A.3    Nahorski, S.R.4
  • 39
    • 0034783667 scopus 로고    scopus 로고
    • Visualization of IP (3) dynamics reveals a novel AMPA receptor-triggered IP (3) production pathway mediated by voltage-dependent Ca2+ influx in purkinje cells
    • Okubo Y, Kakizawa S, Hirose K, Iino M (2001) Visualization of IP(3) dynamics reveals a novel AMPA receptor-triggered IP(3) production pathway mediated by voltage-dependent Ca2+ influx in Purkinje cells. Neuron 32(1):113-122
    • (2001) Neuron , vol.32 , Issue.1 , pp. 113-122
    • Okubo, Y.1    Kakizawa, S.2    Hirose, K.3    Iino, M.4
  • 40
    • 2442569919 scopus 로고    scopus 로고
    • Oscillations of phospholipase C activity triggered by depolarization and Ca2+ influx in insulin-secreting cells
    • doi:10.1074/jbc.C400088200
    • Thore S, Dyachok O, Tengholm A (2004) Oscillations of phospholipase C activity triggered by depolarization and Ca2+ influx in insulin-secreting cells. J Biol Chem 279(19):19396-19400. doi:10.1074/jbc.C400088200
    • (2004) J Biol Chem , vol.279 , Issue.19 , pp. 19396-19400
    • Thore, S.1    Dyachok, O.2    Tengholm, A.3
  • 41
    • 33644680546 scopus 로고    scopus 로고
    • Inositol (1, 4, 5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells
    • Tamarina NA, Kuznetsov A, Rhodes CJ, Bindokas VP, Philipson LH (2005) Inositol (1, 4, 5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells. Diabetes 54(11):3073-3081
    • (2005) Diabetes , vol.54 , Issue.11 , pp. 3073-3081
    • Tamarina, N.A.1    Kuznetsov, A.2    Rhodes, C.J.3    Bindokas, V.P.4    Philipson, L.H.5
  • 42
    • 2642585010 scopus 로고    scopus 로고
    • Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis
    • doi:10.1074/jbc. M314314200
    • Xia F, Gao X, Kwan E, Lam PP, Chan L, Sy K, Sheu L, Wheeler MB, Gaisano HY, Tsushima RG (2004) Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis. J Biol Chem 279(23):24685-24691. doi:10.1074/jbc. M314314200
    • (2004) J Biol Chem , vol.279 , Issue.23 , pp. 24685-24691
    • Xia, F.1    Gao, X.2    Kwan, E.3    Lam, P.P.4    Chan, L.5    Sy, K.6    Sheu, L.7    Wheeler, M.B.8    Gaisano, H.Y.9    Tsushima, R.G.10
  • 44
    • 0030810066 scopus 로고    scopus 로고
    • Store depletion and calcium influx
    • Parekh AB, Penner R (1997) Store depletion and calcium influx. Physiol Rev 77(4):901-930
    • (1997) Physiol Rev , vol.77 , Issue.4 , pp. 901-930
    • Parekh, A.B.1    Penner, R.2
  • 46
    • 1242314690 scopus 로고    scopus 로고
    • Muscarinic agonists activate Ca2+ store-operated and-independent ionic currents in insulinsecreting HIT-T15 cells and mouse pancreatic beta-cells
    • doi:10.1007/s00232-003-0642-y
    • Mears D, Zimliki CL (2004) Muscarinic agonists activate Ca2+ store-operated and-independent ionic currents in insulinsecreting HIT-T15 cells and mouse pancreatic beta-cells. J Membr Biol 197(1):59-70. doi:10.1007/s00232- 003-0642-y
    • (2004) J Membr Biol , vol.197 , Issue.1 , pp. 59-70
    • Mears, D.1    Zimliki, C.L.2
  • 47
    • 0030609153 scopus 로고    scopus 로고
    • Store-operated Ca2+ entry in insulinreleasing pancreatic beta-cells
    • Liu YJ, Gylfe E (1997) Store-operated Ca2+ entry in insulinreleasing pancreatic beta-cells. Cell Calcium 22(4):277-286
    • (1997) Cell Calcium , vol.22 , Issue.4 , pp. 277-286
    • Liu, Y.J.1    Gylfe, E.2
  • 48
    • 0028358833 scopus 로고
    • Endoplasmic reticulum calcium store regulates membrane potential in mouse islet beta-cells
    • Worley JF III, McIntyre MS, Spencer B, Mertz RJ, Roe MW, Dukes ID (1994) Endoplasmic reticulum calcium store regulates membrane potential in mouse islet beta-cells. J Biol Chem 269(20):14359-14362
    • (1994) J Biol Chem , vol.269 , Issue.20 , pp. 14359-14362
    • Worley III, J.F.1    McIntyre, M.S.2    Spencer, B.3    Mertz, R.J.4    Roe, M.W.5    Dukes, I.D.6
  • 49
    • 0029024670 scopus 로고
    • A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells
    • Bertram R, Smolen P, Sherman A, Mears D, Atwater I, Martin F, Soria B (1995) A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells. Biophys J 68(6):2323-2332
    • (1995) Biophys J , vol.68 , Issue.6 , pp. 2323-2332
    • Bertram, R.1    Smolen, P.2    Sherman, A.3    Mears, D.4    Atwater, I.5    Martin, F.6    Soria, B.7
  • 50
    • 0033575141 scopus 로고    scopus 로고
    • Uptake and release of Ca2+ by the endoplasmic reticulum contribute to the oscillations of the cytosolic Ca2+ concentration triggered by Ca2+ influx in the electrically excitable pancreatic B-cell
    • Gilon P, Arredouani A, Gailly P, Gromada J, Henquin JC (1999) Uptake and release of Ca2+ by the endoplasmic reticulum contribute to the oscillations of the cytosolic Ca2+ concentration triggered by Ca2+ influx in the electrically excitable pancreatic B-cell. J Biol Chem 274(29):20197-20205
    • (1999) J Biol Chem , vol.274 , Issue.29 , pp. 20197-20205
    • Gilon, P.1    Arredouani, A.2    Gailly, P.3    Gromada, J.4    Henquin, J.C.5
  • 51
    • 0032524389 scopus 로고    scopus 로고
    • RasGRP, a Ras guanyl nucleotide-releasing protein with calcium-and diacylglycerol-binding motifs
    • Ebinu JO, Bottorff DA, Chan EY, Stang SL, Dunn RJ, Stone JC (1998) RasGRP, a Ras guanyl nucleotide-releasing protein with calcium-and diacylglycerol-binding motifs. Science 280(5366): 1082-1086
    • (1998) Science , vol.280 , Issue.5366 , pp. 1082-1086
    • Ebinu, J.O.1    Bottorff, D.A.2    Chan, E.Y.3    Stang, S.L.4    Dunn, R.J.5    Stone, J.C.6
  • 53
    • 0037382719 scopus 로고    scopus 로고
    • Differential activation mechanisms of Erk-1/2 and p70(S6 K) by glucose in pancreatic beta-cells
    • Briaud I, Lingohr MK, Dickson LM, Wrede CE, Rhodes CJ (2003) Differential activation mechanisms of Erk-1/2 and p70(S6 K) by glucose in pancreatic beta-cells. Diabetes 52(4): 974-983
    • (2003) Diabetes , vol.52 , Issue.4 , pp. 974-983
    • Briaud, I.1    Lingohr, M.K.2    Dickson, L.M.3    Wrede, C.E.4    Rhodes, C.J.5
  • 54
    • 32144454340 scopus 로고    scopus 로고
    • Muscarinic M1 and M3 receptor binding alterations in pancreas during pancreatic regeneration of young rats
    • Renuka TR, Savitha B, Paulose CS (2005) Muscarinic M1 and M3 receptor binding alterations in pancreas during pancreatic regeneration of young rats. Endocr Res 31(4):259-270
    • (2005) Endocr Res , vol.31 , Issue.4 , pp. 259-270
    • Renuka, T.R.1    Savitha, B.2    Paulose, C.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.