Lessons learned from the transgenic Huntington's disease rats

Neural Plasticity

Volumn 2012, Issue , 2012, Pages

  Vlamings, Rinske ^a   Zeef, Dagmar H ^a   Janssen, Marcus L F ^a   Oosterloo, Mayke ^a   Schaper, FreDeric ^a   Jahanshahi, Ali ^a   Temel, Yasin ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; HUNTINGTIN; HTT PROTEIN, HUMAN; NERVE PROTEIN;

BEHAVIOR; CAG REPEAT; HISTOPATHOLOGY; HUMAN; HUNTINGTON CHOREA; NEUROPHYSIOLOGY; NONHUMAN; PHENOTYPE; REVIEW; TRANSGENIC RAT; ANIMAL; ANIMAL BEHAVIOR; GENETICS; NERVOUS SYSTEM; NERVOUS SYSTEM FUNCTION; NUCLEOTIDE REPEAT; PATHOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; RAT;

ANIMALS; BEHAVIOR, ANIMAL; DNA, COMPLEMENTARY; HUMANS; HUNTINGTON DISEASE; NERVE TISSUE PROTEINS; NERVOUS SYSTEM; NERVOUS SYSTEM PHYSIOLOGICAL PHENOMENA; PHENOTYPE; RATS; RATS, TRANSGENIC; REPETITIVE SEQUENCES, NUCLEIC ACID;

EID: 84864937741     PISSN: 20905904     EISSN: 16875443     Source Type: Journal    
DOI: 10.1155/2012/682712     Document Type: Review

References (72)

1. Walker F. O., Huntington's disease The Lancet 2007 369 9557 218 228 (Pubitemid 46107685)
2. Bonelli R. M., Hofmann P., A systematic review of the treatment studies in Huntington's disease since 1990 Expert Opinion on Pharmacotherapy 2007 8 2 141 153 (Pubitemid 46206617)
3. Myers R. H., Huntington's disease genetics NeuroRx 2004 1 2 255 262 (Pubitemid 46589355)
4. Andresen J. M., Gayan J., Djousse L., Roberts S., Brocklebank D., Cherny S.S., Cardon L. R., Gusella J. F., Macdonald M. E., Myers R. H., Housman D. E., Wexler N.S., Lorimer J., Porter J., Gomez F., Moskowitz C., Gerstenhaber K. P., Shackell E., MarDer K., Penchaszadeh G., Roberts S. A., Brickman A., Brocklebank D., Gray J., Dlouhy S. R., Wiktorski S., Hodes M. E., Conneally P. M., Penney J. B., Gusella J.F., Cha J.-H., Irizarry M., Rosas D., Hersch S., Hollingsworth Z., Young A.B., Housman D. E., De Young M. M., Bonilla E., Stillings T., Negrette A., Snodgrass S. R., Martinez-Jaurrieta M. D., Ramos-Arroyoh M. A., Bickham J., Ramos J. S., Marshall F., Shoulson I., Rey G.J., Feigin A., Arnheim N., Acevedo-Cruz A., Acosta L., Alvir J., Fischbeck K., Thompson L. M., Young A., Dure L., O'Brien C. J., Paulsen J., Moran S. P., Krch D., Hogarth P., Higgins D. S., Landwehrmeyer B., HayDen M. R., Almqvist E. W., Brinkman R. R., Suchowersky O., Durr A., Dodé C., Squitieri F., Morrison P. J., Nance M., Ross C. A., Margolis R. L., Rosenblatt A., Estrella G.-T., Cabrero D.M., Trent R. J. A., McCusker E., Novelletto A., Frontali M., Paulsen J. S., Jones R., Zanko A., Ashizawa T., Lazzarini A., Li J.-L., Wheeler V. C., Russ A. L., Xu G., Mysore J. S., Gillis T., Hakky M., Cupples L. A., Saint-Hilaire M., Hersch S. M., The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset Annals of Human Genetics 2007 71 3 295 301 (Pubitemid 46585671)
5. Andrew S. E., Goldberg Y. P., Kremer B., Telenius H., Theilmann J., Adam S., Starr E., Squitieri F., Lin B., Kalchman M. A., Graham R. K., HayDen M. R., The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease Nature Genetics 1993 4 4 398 403 (Pubitemid 23231490)
6. Gusella J. F., Wexler N. S., Conneally P. M., A polymorphic DNA marker genetically linked to Huntington's disease Nature 1983 306 5940 234 238 (Pubitemid 14232350)
7. MacDonald M. E., Ambrose C. M., Duyao M. P., Myers R. H., Lin C., Srinidhi L., Barnes G., Taylor S. A., James M., Groot N., MacFarlane H., Jenkins B., AnDerson M. A., Wexler N. S., Gusella J. F., Bates G. P., Baxendale S., Hummerich H., Kirby S., A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes Cell 1993 72 6 971 983 (Pubitemid 23110238)
8. Vlamings R., Benazzouz A., Chetrit J., Metabolic and electrophysiological changes in the basal ganglia of transgenic Huntington's disease rats. Neurobiology of Disease. In press
9. Kantor O., Temel Y., Holzmann C., Raber K., Nguyen H. P., Cao C., Trkoglu H.., Rutten B. P. F., Visser-Vandewalle V., Steinbusch H. W. M., Blokland A., Korr H., Riess O., Von Hrsten S., Schmitz C., Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats Neurobiology of Disease 2006 22 3 538 547 (Pubitemid 43832125)
10. Jahanshahi A., Vlamings R., Kaya A. H., Lim L. W., Janssen M. L. F., Tan S., Visser-Vandewalle V., Steinbusch H. W. M., Temel Y., Hyperdopaminergic status in experimental Huntington disease Journal of Neuropathology and Experimental Neurology 2010 69 9 910 917
11. Jackson G. R., Salecker I., Dong X., Yao X., Arnheim N., Faber P. W., MacDonald M. E., Zipursky S. L., Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons Neuron 1998 21 3 633 642 (Pubitemid 28475514)
12. Faber P. W., Voisine C., King D. C., Bates E. A., Hart A. C., Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity Proceedings of the National Academy of Sciences of the United States of America 2002 99 26 17131 17136 (Pubitemid 36034110)
13. Jacobsen J. C., BawDen C. S., Rudiger S. R., McLaughlan C. J., Reid S. J., Waldvogel H. J., MacDonald M. E., Gusella J. F., Walker S. K., Kelly J. M., Webb G. C., Faull R. L. M., Rees M. I., Snell R. G., An ovine transgenic Huntington's disease model Human Molecular Genetics 2010 19 10 1873 1882
14. Morton A. J., Avanzo L. , Executive Decision-making in the domestic sheep PloS one 2011 6 1 e15752
15. Yang D., Wang C. E., Zhao B., Li W., Ouyang Z., Liu Z., Yang H., Fan P., O'Neill A., Gu W., Yi H., Li S., Lai L., Li X. J., Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs Human Molecular Genetics 2010 19 20 3983 3994
16. Yang S. H., Cheng P. H., Banta H., Piotrowska-Nitsche K., Yang J. J., Cheng E. C. H., SnyDer B., Larkin K., Liu J., Orkin J., Fang Z. H., Smith Y., Bachevalier J., Zola S. M., Li S. H., Li X. J., Chan A. W. S., Towards a transgenic model of Huntington's disease in a non-human primate Nature 2008 453 7197 921 924 (Pubitemid 351832563)
17. Von Horsten S., Schmitt I., Nguyen H. P., Holzmann C., Schmidt T., Walther T., BaDer M., Pabst R., Kobbe P., Krotova J., Stiller D., Kask A., Vaarmann A., Rathke-Hartlieb S., Schulz J. B., Grasshoff U., Bauer I., Vieira-Saecker A. M. M., Paul M., Jones L., LinDenberg K. S., Landwehrmeyer B., Bauer A., Li X.-J., Riess O., Transgenic rat model of Huntington's disease Human Molecular Genetics 2003 12 6 617 624 (Pubitemid 36372488)
18. Huntington G., On Chorea The Medical and Surgical Reporter 1872 26 4
19. Paulsen J. S., Ready R. E., Hamilton J. M., Mega M. S., Cummings J. L., Neuropsychiatric aspects of Huntington's disease Journal of Neurology Neurosurgery and Psychiatry 2001 71 3 310 314 (Pubitemid 32772526)
20. Reedeker N., Van Der Mast R. C., Giltay E. J., Van Duijn E., Roos R. A. C., Hypokinesia in Huntington's disease co-occurs with cognitive and global dysfunctioning Movement DisorDers 2010 25 11 1612 1618
21. File S. E., Mahal A., Mangiarini L., Bates G. P., Striking changes in anxiety in Huntington's disease transgenic mice Brain Research 1998 805 1-2 234 240 (Pubitemid 29005139)
22. Nguyen H. P., Kobbe P., Rahne H., Wrpel T., Jger B., Stephan M., Pabst R., Holzmann C., Riess O., Korr H., Kntor O., Petrasch-Parwez E., Wetzel R., Osmand A., Von Hrsten S., Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease Human Molecular Genetics 2006 15 21 3177 3194 (Pubitemid 44605498)
23. Zeef D. H., Vlamings R., Lim L. W., Tan S., Janssen M. L. F., Jahanshahi A., Hoogland G., Prickaerts J., Steinbusch H. W. M., Temel Y., Motor and non-motor behaviour in experimental Huntington's disease Behavioural Brain Research 2012 226 2 435 439
24. Zeef D. H., Van Goethem N. P., Vlamings R., Schaper F., Jahanshahi A., Hescham S., Von Horsten S., Prickaerts J., Temel Y., Memory Deficits in the transgenic rat model of Huntington's disease Behavioural Brain Research 2012 227 1 194 198
25. Ciamei A., Jennifer Morton A., Progressive imbalance in the interaction between spatial and procedural memory systems in the R6/2 mouse model of Huntington's disease Neurobiology of Learning and Memory 2009 92 3 417 428
26. Grahn J. A., Parkinson J. A., Owen A. M., The role of the basal ganglia in learning and memory: neuropsychological studies Behavioural Brain Research 2009 199 1 53 60
27. Ghiglieri V., Sgobio C., Costa C., Picconi B., Calabresi P., Striatum-hippocampus balance: from physiological behavior to interneuronal pathology Progress in Neurobiology 2011 94 2 102 114
28. Mumby D. G., Piterkin P., Lecluse V., Lehmann H., Perirhinal cortex damage and anterograde object-recognition in rats after long retention intervals Behavioural Brain Research 2007 185 2 82 87 (Pubitemid 350011107)
29. Eichenbaum H., Yonelinas A. P., Ranganath C., The medial temporal lobe and recognition memory Annual Review of Neuroscience 2007 30 123 152 (Pubitemid 47224758)
30. Abe H., Ishida Y., Nonaka H., Iwasaki T., Functional difference between rat perirhinal cortex and hippocampus in object and place discrimination tasks Behavioural Brain Research 2009 197 2 388 397
31. Giralt A., Rodrigo T., Martn E. D., Gonzalez J. R., Mil M., Cea V., Dierssen M., Canals J. M., Alberch J., Brain-Derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseC activity and glutamate receptor expression Neuroscience 2009 158 4 1234 1250
32. Murphy K. P. S. J., Carter R. J., Lione L. A., Mangiarini L., Mahal A., Bates G. P., Dunnett S. B., Jennifer Morton A., Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation Journal of Neuroscience 2000 20 13 5115 5123 (Pubitemid 30421714)
33. Milnerwood A. J., Raymond L. A., Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load Journal of Physiology 2007 585 3 817 831
34. Simmons D. A., Rex C. S., Palmer L., Pandyarajan V., Fedulov V., Gall C. M., Lynch G., Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice Proceedings of the National Academy of Sciences of the United States of America 2009 106 12 4906 4911
35. Hhn S., Dallérac G., Faure A., Urbach Y. K., Nguyen H. P., Riess O., Von Hrsten S., le Blanc P., Desvignes N., EL-Massioui N., Brown B. L., Doyére V., Behavioral and in vivo electrophysiological eviDence for presymptomatic alteration of prefrontostriatal processing in the transgenic rat model for huntington disease Journal of Neuroscience 2011 31 24 8986 8997
36. Cao C., Temel Y., Blokland A., Ozen H., Steinbusch H. W. M., Vlamings R., Nguyen H. P., Von Hrsten S., Schmitz C., Visser-Vandewalle V., Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel Behavioural Brain Research 2006 170 2 257 261
37. Dostrovsky J. O., Lozano A. M., Mechanisms of deep brain stimulation Movement DisorDers 2002 17 supplement 3 S63 S68
38. Urbain N., Rentéro N., Gervasoni D., Renaud B., Chouvet G., The switch of subthalamic neurons from an irregular to a bursting pattern does not solely depend on their GABAergic inputs in the anesthetic-free rat Journal of Neuroscience 2002 22 19 8665 8675 (Pubitemid 35387607)
39. Magill P. J., Bolam J. P., BeVan M. D., Relationship of activity in the subthalamic nucleus-globus pallidus network to cortical electroencephalogram Journal of Neuroscience 2000 20 2 820 833 (Pubitemid 30225585)
40. Benazzouz A., Hallett M., Mechanism of action of deep brain stimulation Neurology 2000 55 12 S13 S16
41. Liu X., Ford-Dunn H. L., Hayward G. N., Nandi D., Miall R. C., Aziz T. Z., Stein J. F., The oscillatory activity in the Parkinsonian subthalamic nucleus investigated using the macro-electrodes for deep brain stimulation Clinical Neurophysiology 2002 113 11 1667 1672 (Pubitemid 35335454)
42. BeVan M. D., Magill P. J., Terman D., Bolam J. P., Wilson C. J., Move to the rhythm: oscillations in the subthalamic nucleus-external globus pallidus network Trends in Neurosciences 2002 25 10 525 531 (Pubitemid 35246323)
43. Miller W. C., deLong M. R., Carpenter M. B., Jayaraman A., Altered tonic activity of neurons in the globus pallidus and subthalamic nucleus in the primate model of parkinsonism The Basal Ganglia II: Structure and Function 1987 New York, NY, USA Plenum 415 427
44. Bergman H., Wichmann T., deLong M. R., Reversal of experimental Parkinsonism by lesions of the subthalamic nucleus Science 1990 249 4975 1436 1438
45. Benabid A. L., Pollak P., Louveau A., Henry S., De Rougemont J., Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease Applied Neurophysiology 1987 50 16 344 346 (Pubitemid 18043161)
46. Benazzouz A., Gross C., Feger J., Boraud T., Bioulac B., Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys European Journal of Neuroscience 1993 5 4 382 389 (Pubitemid 23108592)
47. Pollak P., Benabid A. L., Gross C., Gao D. M., Laurent A., Benazzouz A., Hoffmann D., Gentil M., Perret J., Effects of subthalamic nucleus stimulation in Parkinson's disease Revue Neurologique 1993 149 3 175 176 (Pubitemid 23126192)
48. Limousin P., Pollak P., Benazzouz A., Hoffmann D., Le Bas J. F., Broussolle E., Perret J. E., Benabid A. L., Effect on parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation The Lancet 1995 345 8942 91 95
49. Puigserver P., Spiegelman B. M., Peroxisome proliferator-activated receptor- coactivator 1 (PGC-1 ): transcriptional coactivator and metabolic regulator Endocrine Reviews 2003 24 1 78 90 (Pubitemid 36223280)
50. Joel D., Open interconnected model of basal ganglia-thalamocortical circuitry and its releVance to the clinical syndrome of Huntington's disease Movement DisorDers 2001 16 3 407 423 (Pubitemid 36041145)
51. Temel Y., Blokland A., Steinbusch H. W. M., Visser-Vandewalle V., The functional role of the subthalamic nucleus in cognitive and limbic circuits Progress in Neurobiology 2005 76 6 393 413 (Pubitemid 41636778)
52. Zhu Z., Bartol M., Shen K., Johnson S. W., Excitatory effects of dopamine on subthalamic nucleus neurons: In vitro study of rats pretreated with 6-hydroxydopamine and levodopa Brain Research 2002 945 1 31 40 (Pubitemid 34756574)
53. Heinsen H., Strik M., Bauer M., Luther K., Ulmar G., Gangnus D., Jungkunz G., Eisenmenger W., Gotz M., Cortical and striatal neurone number in Huntington's disease Acta Neuropathologica 1994 88 4 320 333 (Pubitemid 24309396)
54. Beal M. F., Ferrante R. J., Experimental therapeutics in transgenic mouse models of Huntington's disease Nature Reviews Neuroscience 2004 5 5 373 384 (Pubitemid 38568498)
55. Slow E. J., Van Raamsdonk J., Rogers D., Coleman S. H., Graham R. K., Deng Y., Oh R., Bissada N., Hossain S. M., Yang Y. Z., Li X. J., Simpson E. M., Gutekunst C. A., Leavitt B. R., HayDen M. R., Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease Human Molecular Genetics 2003 12 13 1555 1567 (Pubitemid 36857303)
56. Vonsattel J. P., Myers R. H., Stevens T. J., Neuropathological classification of Huntington's disease Journal of Neuropathology and Experimental Neurology 1985 44 6 559 577 (Pubitemid 16196286)
57. Miller B. R., Walker A. G., Fowler S. C., Von Hrsten S., Riess O., Johnson M. A., Rebec G. V., Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease Neurobiology of Disease 2010 37 1 106 113
58. MacDonald V., Halliday G. M., Selective loss of pyramidal neurons in the pre-supplementary motor cortex in Parkinson's disease Movement DisorDers 2002 17 6 1166 1173 (Pubitemid 36041329)
59. Bird E. D., Chemical pathology of Huntington's disease Annual Review of Pharmacology and Toxicology 1980 20 533 551
60. Bird E. D., Spokes E. G., Iversen L. L., Dopamine and noradrenaline in post-mortem brain in Huntington's disease and schizophrenic illness Acta Psychiatrica Scandinavica 1980 280 63 73 (Pubitemid 10055006)
61. Spokes E. G. S., Neurochemical alterations in Huntington's chorea. A study of post mortem brain tissue Brain 1980 103 1 179 210 (Pubitemid 10009481)
62. Mason S. L., Barker R. A., Emerging drug therapies in Huntington's disease Expert Opinion on Emerging Drugs 2009 14 2 273 297
63. Haber S. N., Fudge J. L., The primate substantia Nigra and VTA: integrative circuitry and function Critical Reviews in Neurobiology 1997 11 4 323 342 (Pubitemid 127509145)
64. Joel D., Weiner I., The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum Neuroscience 2000 96 3 451 474 (Pubitemid 30136312)
65. Yohrling G. J., Jiang G. C. T., deJohn M. M., Miller D. W., Young A. B., Vrana K. E., Cha J. H. J., Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology Molecular Brain Research 2003 119 1 28 36 (Pubitemid 37324795)
66. Mann D. M. A., Subcortical afferent projection systems in Huntington's chorea Acta Neuropathologica 1989 78 5 551 554 (Pubitemid 19218291)
67. Temel Y., Visser-Vandewalle V., Kaplan S., Kozan R., Daemen M. A. R. C., Blokland A., Schmitz C., Steinbusch H. W. M., Protection of nigral cell death by bilateral subthalamic nucleus stimulation Brain Research 2006 1120 1 100 105 (Pubitemid 44648015)
68. Aumann T. D., Gantois I., Egan K., Vais A., Tomas D., Drago J., Horne M. K., SK channel function regulates the dopamine phenotype of neurons in the substantia nigra pars compacta Experimental Neurology 2008 213 2 419 430
69. Paul G., Meissner W., Rein S., Harnack D., Winter C., Hosmann K., Morgenstern R., Kupsch A., Ablation of the subthalamic nucleus protects dopaminergic phenotype but not cell survival in a rat model of Parkinson's disease Experimental Neurology 2004 185 2 272 280 (Pubitemid 38084853)
70. Bode F. J., Stephan M., Suhling H., Pabst R., Straub R. H., Raber K. A., Bonin M., Nguyen H. P., Riess O., Bauer A., Sjoberg C., Petersén. D., Von Hrsten S., Sex differences in a transgenic rat model of Huntington's disease: Decreased 17 -estradiol levels correlate with reduced numbers of DARPP32+ neurons in males Human Molecular Genetics 2008 17 17 2595 2609
71. Fielding S. A., Brooks S. P., Klein A., Bayram-Weston Z., Jones L., Dunnett S. B., Profiles of motor and cognitive impairment in the transgenic rat model of Huntington's disease Brain Research Bulletin 2012 88 2-3 223 236
72. Brooks S., Fielding S., Dbrssy M., Von Hrsten S., Dunnett S., Subtle but progressive cognitive Deficits in the female tgHD hemizygote rat as demonstrated by operant SILT performance Brain Research Bulletin 2009 79 5 310 315