Subtle but progressive cognitive deficits in the female tgHD hemizygote rat as demonstrated by operant SILT performance

Brain Research Bulletin

Volumn 79, Issue 5, 2009, Pages 310-315

  Brooks, Simon ^a   Fielding, Steven ^a   Döbrössy, Màtè ^b   von Hörsten, Stephan ^c   Dunnett, Stephen ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Huntington's disease; Implicit learning; Operant; SILT; tgHD rat

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENTION DEFICIT DISORDER; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE MODEL; FEMALE; HEMIZYGOTE; HUNTINGTON CHOREA; LEARNING DISORDER; MENTAL PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; STIMULUS RESPONSE; TRANSGENIC RAT;

ANIMALS; COGNITION; COGNITION DISORDERS; CONDITIONING, OPERANT; DISEASE MODELS, ANIMAL; FEMALE; GENOTYPE; HUMANS; HUNTINGTON DISEASE; LEARNING DISORDERS; LONGITUDINAL STUDIES; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RATS; RATS, TRANSGENIC; REACTION TIME;

EID: 67349224632     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2009.03.003     Document Type: Article

References (46)

1. Bauer A., Zilles K., Matusch A., Holzmann C., Riess O., and von Horsten S. Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation. J. Neurochem. 94 (2005) 639-650
2. + neurons in males. Hum. Mol. Genet. 17 (2008) 2595-2609
3. Brooks S.P., Betteridge H., Trueman R.C., Jones L., and Dunnett S.B. Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease. Brain Res. Bull. 69 (2006) 452-457
4. Brooks S.P., Trueman R.C., and Dunnett S.B. Striatal lesions in the mouse disrupt acquisition and retention, but not implicit learning, in the SILT procedural motor learning task. Brain Res. 1185 (2007) 179-188
5. Cao C., Temel T., Blokland A., Ozen H., Steinbusch H.W.M., Vlamings R., Nguyen H.P., von Horsten S., Schmitz C., and Visser-Vandewalle V. Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic rat model. Behav. Brain Res. 170 (2006) 257-261
6. Carter R.J., Lione L.A., Humby T., Mangiarini L., Mahal A., Bates G.P., Dunnett S.B., and Morton A.J. Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J. Neurosci. 19 (1999) 3248-3257
7. Chudasama Y., and Robbins T.W. Psychopharmacological approaches to modulating attention in the five-choice serial reaction time task: implications for schizophrenia. Psychopharmacology 174 (2004) 86-98
8. De la Monte S.M., Vonsattel J.P., and Richardson Jr. E.P. Morphametric demonstration of atrophic changes in the cerebral cortex, white matter and neostriatum in Huntington's disease. J. Neuropath. Exp. Neurol. 47 (1988) 516-552
9. DiFiglia M., Sapp E., Chase K.O., Davis S.W., Bates G.P., Vonsattel J.P., and Aronin N. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neuritis in brain. Science 277 (1997) 1990-1993
10. Dunnett S.B., Meldrum A., and Muir J.L. Frontal-striatal disconnection disrupts cognitive performance of the frontal-type in the rat. Neuroscience 135 (2005) 1055-1065
11. Gutekunst C.-A., Li S.-H., Yi H., Mulroy J.S., Kuemmerle S., Jones R., Rye D., Ferrante R.J., Hersch S.M., and Li X.-J. Nuclear and neurophil aggregates in Huntington's disease: relationship to neuropathology. J. Neurosci. 19 (1999) 2522-2534
12. Harper P.S. Huntington's Disease (1996), W.B. Saunders, London
13. Hedreen J.C., and Folstein S.E. Early loss of neostriatal neurons in Huntington's disease. J. Neuropath. Exp. Neurol. 54 (1995) 105-120
14. Heindel W.C., Salmon D.P., Shults C.W., Walicke P.A., and Butters N. Neuropsychological evidence for multiple implicit memory systems: a comparison of Alzheimer's, Huntington's, and Parkinson's disease patients. J. Neurosci. 9 (1989) 582-587
15. Hickey M.A., Kosmalska A., Enayati J., Cohen R., Zeitlin S., Levine M.S., and Chesselet M.F. Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice. Neuroscience 157 (2008) 280-295
16. Humby T., Laird F.M., Davies W., and Wilkinson L.S. Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype. Eur. J. Neurosci. 11 (1999) 2813-2823
17. Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72 (1993) 971-983
18. Jay J.R., and Dunnett S.B. An operant serial implicit learning task (SILT) in rats: task acquisition, performance and the effects of striatal lesions. J. Neurosci. Methods 163 (2007) 235-244
19. Josiassen R.C., Curry L.M., and Mancall E.L. Development of neuropsychological deficits in Huntington's disease. Arch. Neurol. 40 (1983) 91-796
20. Kàntor O., Temel Y., Holzmann C., Raber K., Nguyen H.-P., Cao C., Turkoglu H.O., Rutten B.P.F., Visser-Vanderwalle V., Steinbusch H.W.M., Blokland A., Korr H., Reiss O., von Horsten S., and Schmitz C. Selective striatal neuron loss and alterations in behaviour correlate with impaired striatal function in Huntington's disease transgenic rats. Neurobiol. Dis. 22 (2006) 538-547
21. Kim J.S., Reading S.A., Brashers-Krug T., Calhoun V.D., Ross C.A., and Pearlson G.D. Functional MRI study of a serial reaction time task in Huntington's disease. Psychiat. Res. 131 (2004) 23-30
22. Knopman D., and Nissen M.J. Procedural learning is impaired in Huntington's disease: evidence from the serial reaction time task. Neuropsychologia 29 (1991) 245-254
23. Lawrence A.D., Sahakian B.J., Hodges J.R., Rosser A.E., Lange K.W., and Robbins T.W. Executive and mnemonic functions in early Huntington's disease. Brain 119 (1996) 1633-1645
24. Lawrence A.D., Sahakian B.J., Rogers R.D., Hodges J.R., and Robbins T.W. Discrimination, reversal, and shift learning in Huntington's disease: mechanisms of impaired response selection. Neuropsychologia 37 (1999) 1359-1374
25. Lawrence A.D., Watkins L.H., Sahakian B.J., Hodges J.R., and Robbins T.W. Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits. Brain 123 (2000) 1349-1364
26. Lin C.-H., Tallaksen-Greene S., Chien W.M., Cearley J.A., Jackson W.S., Crouse A.B., Ren S., Li X.-J., Albin R.L., and Detloff P.J. Neurological abnormalities in a knock-in mouse model of Huntington's disease. Hum. Mol. Genet. 10 (2001) 137-144
27. Lione L.A., Carter R.J., Hunt M.J., Bates G.P., Morton A.J., and Dunnett S.B. Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation. J. Neurosci. 19 (1999) 10428-10437
28. Mangiarini L., Sathasivam K., Seller M., Cozens B., Harper A., Hetherington C., Lawton M., Trottier Y., Lehrach H., Davies S.W., and Bates G.P. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87 (1996) 493-506
29. Menalled L.B., Sison J.D., Wu Y., Olivieri M., Li X.J., Li H., Zeitlin S., and Chesselet M.F. Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice. J. Neurosci. 22 (2002) 8266-8276
30. Muir J.L., Everitt B.J., and Robbins T.W. The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulated, anterior dorsolateral, and parietal cortex lesions on a five choice serial reaction time task. Cereb. Cortex 6 (1996) 470-481
31. Nguyen H.-P., Kobbe P., Rahne H., Wörpol T., Jäger B., Stephan M., Pabst R., Holzmann C., Riess O., Korr H., Kantor O., Petrasch-Parwez E., Wetzel E.R., Osmand A., and von Hörsten S. Behavioural abnormalities precede neuropathological markers in rats transgenic for Huntington's disease. Hum. Mol. Genet. 15 (2006) 3177-3194
32. Petrasch-Parwez E., Nguyen H.-P., Löbbecke-Schumacher M., Habbes H.-W., Wieczorek S., Riess O., Andres K.-H., Dermietzel R., and von Hörsten S. Cellular and subcellular localization of Huntington aggregates in the brain of a rat transgenic for Huntington disease. J. Comp. Neurol. 501 (2007) 716-730
33. Robbins T.W., Muir J.L., Killcross A.S., and Pretsell D. Methods of assessing attention and stimulus control in the rat. In: Sahgal A. (Ed). Behavioural Neuroscience, A Practical Approach vol. 1 (1993), IRL Press, Oxford pp. 13-47
34. Rogers R., Baunez C., Everitt B.J., and Robbins T.W. Lesions of the medial and lateral striatum in the rat produce dissociable deficits in attentional performance. Behav. Neurosci. 115 (2001) 799-815
35. Schilling G., Becher M.W., Sharp A.H., Jinnah H.A., Duan K., Kotzuk J.A., Slunt H.H., Ratovitski T., Cooper J.K., Jenkins N.A., Copeland N.G., Price D.L., Ross C.A., and Borchelt D.R. Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutuan N-terminal fragment of huntingtin. Hum. Mol. Genet. 8 (1999) 397-407
36. Shelbourne P.F., Killeen N., Hevner R.F., Johnston H.M., Tecott L., Lewandoski M., Ennis M., Ramirez L., Li Z., Iannicola C., Littman D.R., and Myers R.M. A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice. Hum. Mol. Genet. 8 (1999) 763-774
37. Slow E.J., van Raamsdonk J., Rogers D., Coleman S.H., Graham R.K., Deng Y., Oh R., Bissada N., Hossain S.M., Yang Y.Z., Li X.J., Simpson E.M., Gutekunst C.A., Leavitt B.R., and Hayden M.R. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum. Mol. Genet. 12 (2003) 1555-1567
38. Temel Y., Cao C., Vlamings R., Blokland A., Ozen H., Steinbusch H.W.M., Michelsen K.A., von Horsten S., Schmitz C., and Visser-Vandewalle V. Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease. Neurosci. Lett. 406 (2006) 138-141
39. Trueman R.C., Brooks S.P., and Dunnett S.B. Implicit learning in a serial choice visual discrimination task in the operant 9-hole box by intact and striatal lesioned mice. Behav. Brain Res. 159 (2005) 313-322
40. Trueman R.C., Brooks S.P., Jones L., and Dunnett S.B. The operant serial implicit learning task reveals early onset motor learning deficits in the Hdh knock-in mouse model of Huntington's disease. Eur. J. Neurosci. 25 2007 (2007) 551-558
41. Turmaine M., Raza A., Mahal A., Mangiarini L., Bates G.P., and Davies S.W. Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 8093-8097
42. von Hörsten S., Schmitt I., Nguyen H.P., Holzmann C., Schmidt T., Walther T., Bader M., Pabst R., Kobbe P., Krotova J., Stiller D., Kask A., Vaarman A., Rathke-Hartlieb S., Schulz J.B., Grasshoff U., Bauer I., Menezes Vieira-Saecker A.M., Paul M., Jones L., Lindenberg K.S., Landwehrmeyer B., Bauer A., Li X.-J., and Riess O. Transgenic rat model of Huntington's disease. Hum. Mol. Genet. 12 (2003) 617-624
43. Vonsattel J.-P., Myers R.H., Stevens T.J., Ferrante R.J., Bird E.D., and Richardson Jr. E.P. Neuropathological classification of Huntington's disease. J. Neuropathol. Exp. Neurol. 44 (1985) 559-577
44. Willingham D.B., and Peterson E.W. Motor skills have diverse neural bases: spared and impaired skill acquisition in Huntington's disease. Neuropsychology 10 (1996) 315-321
45. Q111 knock-in mice. Hum. Mol. Genet. 9 (2000) 503-513
46. White A., and Dunnett S.B. Fronto-striatal disconnection disrupts operant delayed alternation performance in the rat. Neuroreport 17 (2006) 435-441