Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel

Behavioural Brain Research

Volumn 170, Issue 2, 2006, Pages 257-261

  Cao, Chunyan ^a,b,c   Temel, Yasin ^a,c,f   Blokland, Arjan ^a,f   Ozen, Hatice ^a,c,f   Steinbusch, Harry W M ^a,f   Vlamings, Rinske ^a,c,f   Nguyen, Huu Phuc ^d   von Hörsten, Stephan ^e   Schmitz, Christoph ^a,f   Visser Vandewalle, Veerle ^b,f  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f European Graduate School of Neuroscience   (Netherlands)

Author keywords

Choice reaction time; Gene dose; Huntington's disease; Transgenic rat

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CHOREA; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENOTYPE; HUNTINGTON CHOREA; NONHUMAN; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; RAT; REACTION TIME; RESPONSE TIME; SYMPTOMATOLOGY; WILD TYPE;

AGE FACTORS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CHOICE BEHAVIOR; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EXPLORATORY BEHAVIOR; GENOTYPE; HUNTINGTON DISEASE; NUCLEAR PROTEINS; PSYCHOMOTOR PERFORMANCE; RATS; REACTION TIME; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 33646524704     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2006.02.028     Document Type: Article

References (20)

1. The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded, unstable on Huntington's disease chromosomes. Cell 72 (1993) 971-983
2. Anderson K.E., Louis E.D., Stern Y., and Marder K.S. Cognitive correlates of obsessive and compulsive symptoms in Huntington's disease. Am J Psychiatry 158 (2001) 799-801
3. Aron A.R., Sahakian B.J., and Robbins T.W. Distractibility during selection-for-action: differential deficits in Huntington's disease and following frontal lobe damage. Neuropsychologia 41 (2003) 1137-1147
4. Ayalon L., Doron R., Weiner I., and Joel D. Amelioration of behavioral deficits in a rat model of Huntington's disease by an excitotoxic lesion to the globus pallidus. Exp Neurol 186 (2004) 46-58
5. Beal M.F., and Ferrante R.J. Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat Rev Neurosci 5 (2004) 373-384
6. Blokland A. Reaction time responding in rats. Neurosci Biobehav Rev 22 (1998) 847-864
7. Borlongan C.V., Koutouzis T.K., and Sanberg P.R. 3-Nitropropionic acid animal model and Huntington's disease. Neurosci Biobehav Rev 21 (1997) 289-293
8. Desbonnet L., Temel Y., Visser-Vandewalle V., Blokland A., Hornikx V., and Steinbusch H.W. Premature responding following bilateral stimulation of the rat subthalamic nucleus is amplitude and frequency dependent. Brain Res 1008 (2004) 198-204
9. Ellison D.W., Beal M.F., Mazurek M.F., Malloy J.R., Bird E.D., and Martin J.B. Amino acid neurotransmitter abnormalities in Huntington's disease and the quinolinic acid animal model of Huntington's disease. Brain 110 Pt 6 (1987) 1657-1673
10. Gardian G., and Vecsei L. Huntington's disease: pathomechanism and therapeutic perspectives. J Neural Transm 111 (2004) 1485-1494
11. Helmlinger D., Yvert G., Picaud S., Merienne K., Sahel J., Mandel J.L., et al. Progressive retinal degeneration and dysfunction in R6 Huntington's disease mice. Hum Mol Genet 11 (2002) 3351-3359
12. Ho AK, Nestor PJ, Williams GB, Bradshaw JL, Sahakian BJ, Robbins TW, Barker RA, Pseudo-neglect in Huntington's disease correlates with decreased angular gyrus density, 2004; 1061-4.
13. Hodgson J.G., Smith D.J., McCutcheon K., Koide H.B., Nishiyama K., Dinulos M.B., et al. Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype. Hum Mol Genet 5 (1996) 1875-1885
14. Kantor O, Temel Y, Holzmann C, Raber K, Nguyen H.P., Cao C, et al. Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats. Neurobiol Dis, in press.
15. Karnath H.O., Himmelbach M., and Rorden C. The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar. Brain 125 (2002) 350-360
16. MacMillan J.C., Morrison P.J., Nevin N.C., Shaw D.J., Harper P.S., Quarrell O.W., et al. Identification of an expanded CAG repeat in the Huntington's disease gene (IT15) in a family reported to have benign hereditary chorea. J Med Genet 30 (1993) 1012-1013
17. Popovic N., Maingay M., Kirik D., and Brundin P. Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes. Exp Neurol 193 (2005) 65-74
18. Tabrizi S.J., Workman J., Hart P.E., Mangiarini L., Mahal A., Bates G., et al. Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse. Ann Neurol 47 (2000) 80-86
19. Temel Y., Visser-Vandewalle V., Aendekerk B., Rutten B., Tan S., Scholtissen B., et al. Acute and separate modulation of motor and cognitive performance in parkinsonian rats by bilateral stimulation of the subthalamic nucleus. Exp Neurol 193 (2005) 43-52
20. von Horsten S., Schmitt I., Nguyen H.P., Holzmann C., Schmidt T., Walther T., et al. Transgenic rat model of Huntington's disease. Hum Mol Genet 12 (2003) 617-624