Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: Searching for a mimic

Journal of Autoimmunity

Volumn 15, Issue 1, 2000, Pages 51-60

  Sasaki, Motoko ^a   Ansari, Aftab ^b   Pumford, Neil ^c   Van De Water, Judy ^a   Leung, Patrick S C ^a   Humphries, Ken M ^d   Szweda, Luke I ^d   Nakanuma, Yasuni ^e   Roche, Thomas E ^f   Coppel, Ross L ^g   Bach, Jean Francois ^h   Gershwin, M Eric ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ARKANSAS   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e KANAZAWA UNIVERSITY   (Japan)

^f KANSAS STATE UNIVERSITY   (United States)

^g MONASH UNIVERSITY   (Australia)

^h HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Anti mitochondrial autoantibody; Halothane; Lipoic acid; Liver; Primary biliary cirrhosis; Trifluoroacetylated protein

Indexed keywords

HALOTHANE; MITOCHONDRION ANTIBODY; THIOCTIC ACID; TRIFLUOROACETIC ACID;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT; CONTROLLED STUDY; CROSS REACTION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER CELL; MOLECULAR MIMICRY; NONHUMAN; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; RAT;

EID: 0034456203     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.2000.0390     Document Type: Article

References (36)

1. Primary biliary cirrhosis
2. Pathology and immunopathology of primary biliary cirrhosis with emphasis on bile duct lesions: Recent progress
3. Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis
4. Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function
5. Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis
6. Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross-reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex
7. Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme
8. Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, the major autoantigen of primary biliary cirrhosis. Implication for a conformational autoepitope
9. Autoantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope
10. Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies
11. PBC and AMA - What is the connection?
12. Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid
13. The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis
14. Molecular basis of halothane hepatitis
15. Halothane metabolism: Immunochemical evidence for molecular mimicry of trifluoroacetylated liver protein adducts by constitutive polypeptides
16. Investigation of the immunological basis of halothane-induced hepatotoxicity
17. Inhibition of alpha-ketoglutarate dehydrogenase activity by a distinct population of autoantibodies recognizing dihydrolipoamide succinyltransferase in primary biliary cirrhosis
18. Monoclonal antibodies to mitochondrial E2 components define autoepitopes in primary biliary cirrhosis
19. Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2
20. Exposure to the chlorofiuorocarbon substitute 2,2-dichloro-1,1,1-trifluoroethane and the anesthetic agent halothane is associated with transient protein adduct formation in the heart
21. Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: Reaction of lipoic acid with 4-hydroxy-2-nonenal
22. Pyruvate dehydrogenase complex from bovine kidney and heart
23. The EnVision++ system: A new immunohistochemical method for diagnostics and research. Critical comparison with the APAAP, ChemMate, CSA, LABC, and SABC techniques
24. Synthesis and nephrotoxicity of 6-bromo-2,5-dihydroxy-thiophenol
25. Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals
26. Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroacetylated carboxylesterase
27. Serum antibodies from halothane hepatitis patients react with the rat endoplasmic reticulum protein ERp72
28. Halothane metabolism: The dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex molecularly mimics trifluoroacetyl-protein adducts
29. Metabolism of the hydrochlorofluorocarbon 1,2-dichloro-1,1-difluoroethane
30. Site-directed mutagenesis of lysine within the immunodominant autoepitope of PDC-E2
31. Lipoylated and unlipoylated domains of human PDC-E2 as autoantigens in primary biliary cirrhosis: Significance of lipoate attachment
32. Alpha-lipoic acid in liver metabolism and disease
33. Elucidation of antioxidant activity of alpha-lipoic acid toward hydroxyl radical
34. Alpha-lipoic acid as a biological antioxidant
35. Molecular mimicry in halothane hepatitis: Biochemical and structural characterization of lipoylated autoantigens