In situ nucleic acid detection of PDC-E2, BCOADC-E2, OGDC-E2, PDC-E1α, BCOADC-E1α, OGDC-E1, and the E3 binding protein (protein X) in primary biliary cirrhosis

Hepatology

Volumn 30, Issue 1, 1999, Pages 36-45

  Harada, Kenichi ^a   Sudo, Yoshiko ^a   Kono, Naoko ^a   Ozaki, Satoru ^a   Tsuneyama, Koichi ^a   Eric Gershwin, M ^b   Nakanuma, Yasuni ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOISOVALERATE DEHYDROGENASE (LIPOAMIDE); BINDING PROTEIN; OXOGLUTARATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE COMPLEX;

ARTICLE; BILE DUCT; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CROSS REACTION; EPITHELIUM CELL; HEPATOBILIARY DISEASE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; NUCLEIC ACID ANALYSIS; NUCLEIC ACID SYNTHESIS; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

3-METHYL-2-OXOBUTANOATE DEHYDROGENASE (LIPOAMIDE); AGED; BILE DUCTS; BLOTTING, NORTHERN; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE; FEMALE; HUMANS; IN SITU HYBRIDIZATION; KETOGLUTARATE DEHYDROGENASE COMPLEX; KETONE OXIDOREDUCTASES; LIVER; LIVER CIRRHOSIS, BILIARY; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MULTIENZYME COMPLEXES; PEPTIDES; PYRUVATE DEHYDROGENASE COMPLEX; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0033063029     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510300145     Document Type: Article

References (23)

1. Scheuer PJ. Liver biopsy interpretation. 3rd ed. London: Bailliere Tindall, 1980.
2. Rubin E, Schaffner F, Popper H. Primary biliary cirrhosis. Am J Pathol 1965;46:387-407.
3. Kaplan MM. Primary biliary cirrhosis. N Engl J Med 1996;335:1570-1580.
4. Fussey SP, Guest JR, James OF, Basendine MF, Yeaman SJ. Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis. Proc Natl Acad Sci U S A 1988;85:8654-8658.
5. Van de Water J, Fregeau D, Davis P, Ansari A, Danner D, Leung P, Coppel R, et al. Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function. J Immunol 1998;141:2321-2324.
6. Coppel RL, McNeilage LJ, Surh CD, Van de Water J, Spithill TW, Whittingham S, Gershwin ME. Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase. Proc Natl Acad Sci U S A 1988;85:7317-7321.
7. Kaplan MM, Gandolfo JV, Quaroni EG. An enzyme-linked immunosorbent assay (ELISA) for detecting antimitochondrial antibody. HEPATOLOGY 1984;4:727-730.
8. Gershwin ME, Mackay IR. Primary biliary cirrhosis: paradigm or paradox for autoimmunity. Gastroenterology 1991;100:822-833.
9. Gershwin ME, Coppel RL, Mackay IR. Primary biliary cirrhosis and mitochondrial autoantigens-insights from molecular biology. HEPATOLOGY 1998;8:147-151.
10. Yeaman SJ, Fussey SP, Danner DJ, James OF, Mutimer DJ, Bassendine ME Primary biliary cirrhosis: identification of two major M2 mitochondrial autoantigens. Lancet 1988;1:1067-1070.
11. Fregeau DR, Davis PA, Danner DJ, Ansari A, Coppel RL, Dickson ER, Gershwin ME. Antimitochondrial antibodies of primary biliary cirrhosis recognize dehydrolipoamide acyltransferase and inhibit enzyme function of the branched chain alpha-ketoacid dehydrogenase complex. J Immunol 1989;142:3815-3820.
12. Fregeau DR, Prindiville T, Coppel RL, Kaplan M, Dickson ER, Gershwin ME. Inhibition of alpha-ketoglutarate dehydrogenase activity by a distinct population of autoantibodies recognizing dihydrolipoamide succinyltransferase in primary biliary cirrhosis. HEPATOLOGY 1990;11;975-981.
13. Surh CD, Roche TE, Danner DJ, Ansari A, Coppel RL, Prindiville T, Dickson ER, et al. Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross-reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex. HEPATOLOGY 1989;10:127-133.
14. Fussey SP, Bassendine MF, Fittes D, Turner IB, James OF, Yeaman SJ. The El alpha and beta subunits of the pyruvate dehydrogenase complex are M2'd' and M2'e' autoantigens in primary biliary cirrhosis. Clin Sci 1989;77:365-368.
15. Fregeau DR, Roche TE, Davis PA, Coppel R, Gershwin ME. Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for El alpha, a non-lipoic acid containing mitochondrial enzyme. J Immunol 1990;144:1671-1676.
16. Nakanuma Y, Ohta G. Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis. Gastroenterology 1979;76:1326-1332.
17. Nakanuma Y, Tsuneyama K, Kono N, Hoso M, Van de Water J, Gershwin ME. Biliary epithelial expression of pyruvate dehydrogenase complex in primary biliary cirrhosis: an immunohistochemical and immunoelectron microscopic study. Hum Pathol 1995;26:92-98.
18. Joplin R, Lindsay JG, Hubscher SG, Johnson GD, Shaw JC, Strain AJ, Neuberger JM. Distribution of dihydrolipoamide acetyltransferase (E2) in the liver and portal lymph nodes of patients with primary biliary cirrhosis: an immunohistochemical study. HEPATOLOGY 1991;14:442-447.
19. Joplin RE, Johnson GD, Matthews JB, Hamburger J, Lindsay JG, Hubscher SG, Strain AJ, et al. Distribution of pyruvate dehydrogenase dihydrolipoamide acetyltransferase (PDC-E2) and another mitochondrial marker in salivary gland and biliary epithelium from patients with primary biliary cirrhosis. HEPATOLOGY 1994;19:1375-1380.
20. Joplin R, Lindsay JG, Johnson GD, Strain A, Neuberger J. Membrane dihydrolipoamide acetyltransferase (E2) on human biliary epithelial cells in primary biliary cirrhosis. Lancet 1992;339:93-94.
21. Tsuneyama K, Van de Water J, Leung PS, Cha S, Nakanuma Y, Kaplan M, De Lellis R, et al. Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatibility complex class II and BB1/B7 expression. HEPATOLOGY 1995;21:1031-1037.
22. Van de Water J, Turchany J, Leung PS, Lake J, Munoz S, Surh CD, Coppel R, et al. Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2. J Clin Invest 1993;91:2653-2664.
23. Van de Water J, Gerson LB, Ferrell LD, Lake JR, Coppel RL, Batts KP, Wiesner RH, et al. Immunohistochemical evidence of disease recurrence after liver transplantation for primary biliary cirrhosis. HEPATOLOGY 1996;24:1079-1084.