Anti-Helicobacter pylori antibody responses specific for VacA do not trigger primary biliary cirrhosis-specific antimitochondrial antibodies

European Journal of Gastroenterology and Hepatology

Volumn 21, Issue 10, 2009, Pages 1220-

  Koutsoumpas, Andreas ^a,c   Mytilinaiou, Maria ^a   Polymeros, Dimitrios ^b   Dalekos, George N ^c,d   Bogdanos, Dimitrios Petrou ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^c UNIVERSITY OF THESSALY   (Greece)

^d INSTITUTE OF HUMAN PERFORMANCE AND REHABILITATION   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN G ANTIBODY; MITOCHONDRION ANTIBODY; PYRUVATE DEHYDROGENASE COMPLEX E 2 AUTOANTIBODY; UNCLASSIFIED DRUG; VACUOLATING TOXIN; BACTERIAL PROTEIN; BACTERIUM ANTIBODY; DIHYDROLIPOAMIDE ACETYLTRANSFERASE; VACA PROTEIN, HELICOBACTER PYLORI;

ANTIBODY RESPONSE; ANTIGEN BINDING; CONTROLLED STUDY; CROSS REACTION; HELICOBACTER PYLORI; HUMAN; IMMUNOBLOTTING; IMMUNOREACTIVITY; LETTER; MAJOR CLINICAL STUDY; MOLECULAR MIMICRY; PATHOGENESIS; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; ANIMAL; BILIARY CIRRHOSIS; BIOSYNTHESIS; BLOOD; IMMUNOLOGY; LIVER MITOCHONDRION; MOUSE;

ANIMALS; ANTIBODIES, BACTERIAL; AUTOANTIBODIES; BACTERIAL PROTEINS; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE; HELICOBACTER PYLORI; HUMANS; LIVER CIRRHOSIS, BILIARY; MICE; MITOCHONDRIA, LIVER; MOLECULAR MIMICRY;

EID: 70349747358     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MEG.0b013e32831a4807     Document Type: Letter

References (5)

1. Goo MJ, Ki MR, Lee HR, Hong IH, Park JK, Yang HJ, et al. Primary biliary cirrhosis, similar to that in human beings, in a male C57BL/6 mouse infected with Helicobacter Pylori. Eur J Gastroenterol Hepatol 2008; 20:1045-1048.
2. Bogdanos DP, Baum H, Grasso A, Okamoto M, Butler P, Ma Y, et al. Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis. J Hepatol 2004; 40:31-39. (Pubitemid 38064710)
3. Bogdanos DP, Baum H, Gunsar F, Arioli D, Polymeros D, Ma Y, et al. Extensive homology between the major immunodominant mitochondrial antigen in primary biliary cirrhosis and Helicobacter pylori does not lead to immunological cross-reactivity. Scand J Gastroenterol 2004; 39: 981-987. (Pubitemid 39388463)
4. Bogdanos DP, Baum H, Okamoto M, Montalto P, Sharma UC, Rigopoulou EI, et al. Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its Lactobacillus mimic. Hepatology 2005; 42:458-465. (Pubitemid 41061099)
5. Bogdanos D, Pusl T, Rust C, Vergani D, Beuers U. Primary biliary cirrhosis following lactobacillus vaccination for recurrent vaginitis. J Hepatol 2008; 49:466-473.