Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach

Environmental Health Perspectives

Volumn 120, Issue 8, 2012, Pages 1150-1156

  Shukla, Sunita J ^a   Huang, Ruili ^a   Simmons, Steven O ^b   Tice, Raymond R ^c   Witt, Kristine L ^c   Vanleer, Danielle ^a   Ramabhadran, Ram ^b   Austin, Christopher P ^a   Xia, Menghang ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

ARE; Nrf2; Oxidative stress; QHTS; Tox21; Toxicity

Indexed keywords

ENVIRONMENTAL CHEMICAL; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BIOLOGICAL ACTIVITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; REPORTER GENE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; UPREGULATION;

ANTIOXIDANTS; CELL LINE; ENVIRONMENTAL POLLUTANTS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864746527     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1104709     Document Type: Article

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