TDAG51 mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium

American Journal of Physiology - Renal Physiology

Volumn 303, Issue 3, 2012, Pages

  Dickhout, Jeffrey G ^a   Carlisle, Rachel E ^a   Heffernan, Alana ^a   Brimble, Elise ^a   Liu, Limin ^a   Jerome, Danielle ^a   Collins, Celeste A ^a   Mohammed Ali, Zahraa ^a   Margetts, Peter J ^a   Austin, Richard C ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Chronic kidney disease; Endoplasmic reticulum stress; Fibrosis; TGF 1; catenin

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; CALCIUM ION; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; INITIATION FACTOR 2ALPHA; REGULATOR PROTEIN; T CELL DEATH ASSOCIATED GENE 51 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VINCULIN; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN CELL; KIDNEY FIBROSIS; KIDNEY PROXIMAL TUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 84864742240     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00481.2011     Document Type: Article

References (56)

1. +)ATPase of rat kidney: purification, biosynthesis, and processing. Cell Struct Funct 11: 259-271, 1986.
2. Al-Hashimi AA, Caldwell J, Gonzalez-Gronow M, Pizzo SV, Aboum-rad D, Pozza L, Al-Bayati H, Weitz JI, Stafford A, Chan H, Kapoor A, Jacobsen DW, Dickhout JG, Austin RC. Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores. J Biol Chem 285: 28912-28923, 2010.
3. Araki S, Eitel JA, Batuello CN, Bijangi-Vishehsaraei K, Xie XJ, Danielpour D, Pollok KE, Boothman DA, Mayo LD. TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. J Clin Invest 120: 290-302, 2010.
4. Berglund L, Bjorling E, Oksvold P, Fagerberg L, Asplund A, Szig-yarto CA, Persson A, Ottosson J, Wernerus H, Nilsson P, Lundberg E, Sivertsson A, Navani S, Wester K, Kampf C, Hober S, Ponten F, Uhlen M. A genecentric Human Protein Atlas for expression profiles based on antibodies. Mol Cell Proteomics 7: 2019-2027, 2008.
5. Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2: 326-332, 2000.
6. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 307: 935-939, 2005.
7. Cannito S, Novo E, Di Bonzo LV, Busletta C, Colombatto S, Parola M. Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and disease. Antioxid Redox Signal 12: 1383-1430, 2010.
8. Chiurchiu C, Remuzzi G, Ruggenenti P. Angiotensin-converting enzyme inhibition and renal protection in nondiabetic patients: the data of the meta-analyses. J Am Soc Nephrol 16, Suppl 1: S58-S63, 2005.
9. Coresh J, Wei GL, McQuillan G, Brancati FL, Levey AS, Jones C, Klag MJ. Prevalence of high blood pressure and elevated serum creatinine level in the United States: findings from the third National Health and Nutrition Examination Survey (1988-1994). Arch Intern Med 161: 1207-1216, 2001.
10. Cunard R, Sharma K. The endoplasmic reticulum stress response and diabetic kidney disease. Am J Physiol Renal Physiol 300: F1054-F1061, 2011.
11. Cybulsky AV. Endoplasmic reticulum stress in proteinuric kidney disease. Kidney Int 77: 187-193, 2010.
12. Dickhout JG, Carlisle RE, Austin RC. Inter-relationship between cardiac hypertrophy, heart failure and chronic kidney disease- endoplasmic reticulum stress as a mediator of pathogenesis. Circ Res 108: 629-642, 2011.
13. Dickhout JG, Colgan SM, Lhotak S, Austin RC. Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome-a balancing act between plaque stability and rupture. Circulation 116: 1214-1216, 2007.
14. Dickhout JG, Hossain GS, Pozza LM, Zhou J, Lhotak S, Austin RC. Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis. Arterioscler Thromb Vasc Biol 25: 2623-2629, 2005.
15. Dickhout JG, Krepinsky JC. Endoplasmic reticulum stress and renal disease. Antioxid Redox Signal 11: 2341-2352, 2009.
16. Dickhout JG, Lhotak S, Hilditch BA, Basseri S, Colgan SM, Lynn EG, Carlisle RE, Zhou J, Sood SK, Ingram AJ, Austin RC. Induction of the unfolded protein response after monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions. FASEB J 25: 576-589, 2011.
17. Dickhout JG, Sood SK, Austin RC. Role of endoplasmic reticulum calcium disequilibria in the mechanism of homocysteine-induced ER stress. Antioxid Redox Signal 9: 1863-1873, 2007.
18. El Kossi M, El Nahas M. Epidemiology and pathophysiology of chronic kidney disease: natural history, risk factors, and management. In: Comprehensive Clinical Nephrology, edited by Feehally J and Johnson RJ. Philadelphia, PA: Elsevier, 2007, p. 813-821.
19. El-Nahas AM. Plasticity of kidney cells: role in kidney remodeling and scarring. Kidney Int 64: 1553-1563, 2003.
20. Fellstrom B. Cyclosporine nephrotoxicity. Transplant Proc 36: 220S- 223S, 2004.
21. Fioretto P, Najafian B, Sutherland DE, Mauer M. Tacrolimus and cyclosporine nephrotoxicity in native kidneys of pancreas transplant recipients. Clin J Am Soc Nephrol 6: 101-106, 2010.
22. Frank D, Mendelsohn CL, Ciccone E, Svensson K, Ohlsson R, Tycko B. A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. Mamm Genome 10: 1150-1159, 1999.
23. Garriock RJ, Krieg PA. Wnt11-R signaling regulates a calcium sensitive EMT event essential for dorsal fin development of Xenopus. Dev Biol 304: 127-140, 2007.
24. Gaspar C, Cardoso J, Franken P, Molenaar L, Morreau H, Moslein G, Sampson J, Boer JM, de Menezes RX, Fodde R. Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. Am J Pathol 172: 1363-1380, 2008.
25. Goldmann WH, Ingber DE. Intact vinculin protein is required for control of cell shape, cell mechanics, and rac-dependent lamellipodia formation. Biochem Biophys Res Commun 290: 749-755, 2002.
26. Gomes I, Xiong W, Miki T, Rosner MR. A proline- and glutamine-rich protein promotes apoptosis in neuronal cells. J Neurochem 73: 612-622, 1999.
27. Grande MT, Lopez-Novoa JM. Fibroblast activation and myofibroblast generation in obstructive nephropathy. Nat Rev Nephrol 5: 319-328, 2009.
28. Haslam RJ, Koide HB, Hemmings BA. Pleckstrin domain homology. Nature 363: 309-310, 1993.
29. He W, Dai C, Li Y, Zeng G, Monga SP, Liu Y. Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 20: 765-776, 2009.
30. Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, Saito Y, Johnson RS, Kretzler M, Cohen CD, Eckardt KU, Iwano M, Haase VH. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 117: 3810-3820, 2007.
31. Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D. Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product. Cell Signal 13: 345-352, 2001.
32. Hossain GS, van Thienen JV, Werstuck GH, Zhou J, Sood SK, Dickhout JG, de Koning AB, Tang D, Wu D, Falk E, Poddar R, Jacobsen DW, Zhang K, Kaufman RJ, Austin RC. TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the development of atherosclerosis in hyperhomocys-teinemia. J Biol Chem 278: 30317-30327, 2003.
33. Ingley E, Hemmings BA. Pleckstrin homology (PH) domains in signal transduction. J Cell Biochem 56: 436-443, 1994.
34. Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110: 341-350, 2002.
35. Jafar TH, Stark PC, Schmid CH, Landa M, Maschio G, Marcantoni C, de Jong PE, de Zeeuw D, Shahinfar S, Ruggenenti P, Remuzzi G, Levey AS. Proteinuria as a modifiable risk factor for the progression of non-diabetic renal disease. Kidney Int 60: 1131-1140, 2001.
36. James MT, Hemmelgarn BR, Tonelli M. Early recognition and preven tion of chronic kidney disease. Lancet 375: 1296-1309, 2010.
37. Joo JH, Liao G, Collins JB, Grissom SF, Jetten AM. Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum stress response. Cancer Res 67: 7929-7936, 2007.
38. Liu Y. New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 21: 212-222, 2010.
39. Margetts PJ, Bonniaud P, Liu L, Hoff CM, Holmes CJ, West-Mays JA, Kelly MM. Transient overexpression of TGF-beta1 induces epithelial mesenchymal transition in the rodent peritoneum. J Am Soc Nephrol 16: 425-436, 2005.
40. Masszi A, Fan L, Rosivall L, McCulloch CA, Rotstein OD, Mucsi I, Kapus A. Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin. Am J Pathol 165: 1955-1967, 2004.
41. Mathew A, Cunard R, Sharma K. Antifibrotic treatment and other new strategies for improving renal outcomes. Contrib Nephrol 170: 217-227, 2011.
42. McMorrow T, Gaffney MM, Slattery C, Campbell E, Ryan MP. Cyclosporine A induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells. Nephrol Dial Transplant 20: 2215-2225, 2005.
43. Metcalfe W. How does early chronic kidney disease progress? A background paper prepared for the UK Consensus Conference on early chronic kidney disease. Nephrol Dial Transplant 22 Suppl 9: ix26-ix30, 2007.
44. Oloumi A, McPhee T, Dedhar S. Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase. Biochim Biophys Acta 1691: 1-15, 2004.
45. Pallet N, Bouvier N, Bendjallabah A, Rabant M, Flinois JP, Hertig A, Legendre C, Beaune P, Thervet E, Anglicheau D. Cyclosporine-induced endoplasmic reticulum stress triggers tubular phenotypic changes and death. Am J Transplant 8: 2283-2296, 2008.
46. Park CG, Lee SY, Kandala G, Choi Y. A novel gene product that couples TCR signaling to Fas(CD95) expression in activation-induced cell death. Immunity 4: 583-591, 1996.
47. Pichler RH, Franceschini N, Young BA, Hugo C, Andoh TF, Burd-mann EA, Shankland SJ, Alpers CE, Bennett WM, Couser WG. Pathogenesis of cyclosporine nephropathy: roles of angiotensin II and osteopontin. J Am Soc Nephrol 6: 1186-1196, 1995.
48. Rho J, Gong S, Kim N, Choi Y. TDAG51 is not essential for Fas/CD95 regulation and apoptosis in vivo. Mol Cell Biol 21: 8365-8370, 2001.
49. Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM. PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. Cancer Res 71: 3709-3719, 2011.
50. Schroder M, Kaufman RJ. ER stress and the unfolded protein response. Mutat Res 569: 29-63, 2005.
51. Segditsas S, Sieber O, Deheragoda M, East P, Rowan A, Jeffery R, Nye E, Clark S, Spencer-Dene B, Stamp G, Poulsom R, Suraweera N, Silver A, Ilyas M, Tomlinson I. Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice. Hum Mol Genet 17: 3864-3875, 2008.
52. Slattery C, Campbell E, McMorrow T, Ryan MP. Cyclosporine A-in-duced renal fibrosis: a role for epithelial-mesenchymal transition. Am J Pathol 167: 395-407, 2005.
53. Ulianich L, Garbi C, Treglia AS, Punzi D, Miele C, Raciti GA, Beguinot F, Consiglio E, Di Jeso B. ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like pheno-type in PC Cl3 thyroid cells. J Cell Sci 121: 477-486, 2008.
54. Vasyutina E, Treier M. Molecular mechanisms in renal degenerative disease. Semin Cell Dev Biol 21: 831-837, 2010.
55. Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 19: 2282-2287, 2008.
56. Zeisberg M, Neilson EG. Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 21: 1819-1834, 2010.