Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores

Journal of Biological Chemistry

Volumn 285, Issue 37, 2010, Pages 28912-28923

  Al Hashimi, Ali A ^a   Caldwell, Jennifer ^a   Gonzalez Gronow, Mario ^c   Pizzo, Salvatore V ^c   Aboumrad, Danya ^a   Pozza, Lindsay ^a   Al Bayati, Hiam ^a   Weitz, Jeffrey I ^b,c   Stafford, Alan ^b   Chan, Howard ^b   Kapoor, Anil ^a   Jacobsen, Donald W ^d,e   Dickhout, Jeffrey G ^c   Austin, Richard C ^a,b  

^a ST JOSEPH S HOSPITAL   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c DUKE UNIVERSITY   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CALCIUM; CELL CULTURE; PUMPS;

AUTOANTIBODIES; CANCER CELLS; CANCER PATIENTS; CELL SURFACES; CYTOSOLIC; DOSE-DEPENDENT; ENDOPLASMIC RETICULUM; ER STRESS; HUMAN CANCER CELLS; MOLECULAR CHAPERONES; N-TERMINALS; PHOSPHATIDYLSERINE; PHOSPHOLIPASE C; PLASMA MEMBRANES; PROSTATE CANCERS; THAPSIGARGINS; TISSUE FACTORS; VENOUS THROMBOEMBOLISM;

CELL MEMBRANES;

CYCLINE; EPITOPE; GLUCOSE REGULATED PROTEIN 78; PHOSPHOLIPASE C; PROCOAGULANT; THAPSIGARGIN; THROMBOPLASTIN; AUTOANTIBODY; CALCIUM; CANCER ANTIBODY; ENZYME INHIBITOR; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; PHOSPHATIDYLSERINE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOTINYLATION; CALCIUM TRANSPORT; CANCER CELL; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; COMPLICATION; DRUG EFFECTS; IMMUNOLOGY; MALE; METABOLISM; PROSTATE TUMOR; TUMOR CELL LINE; VENOUS THROMBOEMBOLISM;

ANTIBODIES, NEOPLASM; AUTOANTIBODIES; CALCIUM; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; EPITOPES; HEAT-SHOCK PROTEINS; HUMANS; MALE; PHOSPHATIDYLSERINES; PROSTATIC NEOPLASMS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SIGNAL TRANSDUCTION; THAPSIGARGIN; THROMBOPLASTIN; TYPE C PHOSPHOLIPASES; VENOUS THROMBOEMBOLISM;

EID: 77956500946     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.119107     Document Type: Article

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