-
1
-
-
41149107510
-
The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine
-
Eyden B. The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine. J Cell Mol Med 2008, 12:22-37.
-
(2008)
J Cell Mol Med
, vol.12
, pp. 22-37
-
-
Eyden, B.1
-
2
-
-
68549091057
-
Fibroblast activation and myofibroblast generation in obstructive nephropathy
-
Grande M.T., Lopez-Novoa J.M. Fibroblast activation and myofibroblast generation in obstructive nephropathy. Nat Rev Nephrol 2009, 5:319-328.
-
(2009)
Nat Rev Nephrol
, vol.5
, pp. 319-328
-
-
Grande, M.T.1
Lopez-Novoa, J.M.2
-
3
-
-
0036322007
-
Evidence that fibroblasts derive from epithelium during tissue fibrosis
-
Iwano M., Plieth D., Danoff T.M., Xue C., Okada H., Neilson E.G. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002, 110:341-350.
-
(2002)
J Clin Invest
, vol.110
, pp. 341-350
-
-
Iwano, M.1
Plieth, D.2
Danoff, T.M.3
Xue, C.4
Okada, H.5
Neilson, E.G.6
-
4
-
-
55249103431
-
Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
-
Zeisberg E.M., Potenta S.E., Sugimoto H., Zeisberg M., Kalluri R. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 2008, 19:2282-2287.
-
(2008)
J Am Soc Nephrol
, vol.19
, pp. 2282-2287
-
-
Zeisberg, E.M.1
Potenta, S.E.2
Sugimoto, H.3
Zeisberg, M.4
Kalluri, R.5
-
5
-
-
33845973760
-
Bone marrow-derived myofibroblasts contribute to the renal interstitial myofibroblast population and produce procollagen I after ischemia/reperfusion in rats
-
Broekema M., Harmsen M.C., van Luyn M.J., Koerts J.A., Petersen A.H., van Kooten T.G., et al. Bone marrow-derived myofibroblasts contribute to the renal interstitial myofibroblast population and produce procollagen I after ischemia/reperfusion in rats. J Am Soc Nephrol 2007, 18:165-175.
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 165-175
-
-
Broekema, M.1
Harmsen, M.C.2
van Luyn, M.J.3
Koerts, J.A.4
Petersen, A.H.5
van Kooten, T.G.6
-
6
-
-
73949096744
-
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
-
Humphreys B.D., Lin S.L., Kobayashi A., Hudson T.E., Nowlin B.T., Bonventre J.V., et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2010, 176:85-97.
-
(2010)
Am J Pathol
, vol.176
, pp. 85-97
-
-
Humphreys, B.D.1
Lin, S.L.2
Kobayashi, A.3
Hudson, T.E.4
Nowlin, B.T.5
Bonventre, J.V.6
-
7
-
-
77957252460
-
Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells
-
Koesters R., Kaissling B., Lehir M., Picard N., Theilig F., Gebhardt R., et al. Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am J Pathol 2010, 177:632-643.
-
(2010)
Am J Pathol
, vol.177
, pp. 632-643
-
-
Koesters, R.1
Kaissling, B.2
Lehir, M.3
Picard, N.4
Theilig, F.5
Gebhardt, R.6
-
8
-
-
77955602944
-
Resolved: EMT produces fibroblasts in the kidney
-
Zeisberg M., Duffield J.S. Resolved: EMT produces fibroblasts in the kidney. J Am Soc Nephrol 2010, 21:1247-1253.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 1247-1253
-
-
Zeisberg, M.1
Duffield, J.S.2
-
9
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.Y.3
Nieto, M.A.4
-
11
-
-
33746891890
-
The primary cilium as the cell's antenna: signaling at a sensory organelle
-
Singla V., Reiter J.F. The primary cilium as the cell's antenna: signaling at a sensory organelle. Science 2006, 313:629-633.
-
(2006)
Science
, vol.313
, pp. 629-633
-
-
Singla, V.1
Reiter, J.F.2
-
12
-
-
67649844614
-
Polycystins and primary cilia: primers for cell cycle progression
-
Zhou J. Polycystins and primary cilia: primers for cell cycle progression. Annu Rev Physiol 2009, 71:83-113.
-
(2009)
Annu Rev Physiol
, vol.71
, pp. 83-113
-
-
Zhou, J.1
-
13
-
-
3242728834
-
Polycystins: from mechanosensation to gene regulation
-
Delmas P. Polycystins: from mechanosensation to gene regulation. Cell 2004, 118:145-148.
-
(2004)
Cell
, vol.118
, pp. 145-148
-
-
Delmas, P.1
-
14
-
-
58149504281
-
Nephronophthisis: disease mechanisms of a ciliopathy
-
Hildebrandt F., Attanasio M., Otto E. Nephronophthisis: disease mechanisms of a ciliopathy. J Am Soc Nephrol 2009, 20:23-35.
-
(2009)
J Am Soc Nephrol
, vol.20
, pp. 23-35
-
-
Hildebrandt, F.1
Attanasio, M.2
Otto, E.3
-
15
-
-
51149118892
-
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice
-
Grigoryan T., Wend P., Klaus A., Birchmeier W. Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev 2008, 22:2308-2341.
-
(2008)
Genes Dev
, vol.22
, pp. 2308-2341
-
-
Grigoryan, T.1
Wend, P.2
Klaus, A.3
Birchmeier, W.4
-
16
-
-
53349173236
-
Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling
-
Lal M., Song X., Pluznick J.L., Di Giovanni V., Merrick D.M., Rosenblum N.D., et al. Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. Hum Mol Genet 2008, 17:3105-3117.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 3105-3117
-
-
Lal, M.1
Song, X.2
Pluznick, J.L.3
Di Giovanni, V.4
Merrick, D.M.5
Rosenblum, N.D.6
-
17
-
-
41549092173
-
Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia
-
Bergmann C., Fliegauf M., Bruchle N.O., Frank V., Olbrich H., Kirschner J., et al. Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet 2008, 82:959-970.
-
(2008)
Am J Hum Genet
, vol.82
, pp. 959-970
-
-
Bergmann, C.1
Fliegauf, M.2
Bruchle, N.O.3
Frank, V.4
Olbrich, H.5
Kirschner, J.6
-
18
-
-
20944435539
-
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways
-
Simons M., Gloy J., Ganner A., Bullerkotte A., Bashkurov M., Kronig C., et al. Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet 2005, 37:537-543.
-
(2005)
Nat Genet
, vol.37
, pp. 537-543
-
-
Simons, M.1
Gloy, J.2
Ganner, A.3
Bullerkotte, A.4
Bashkurov, M.5
Kronig, C.6
-
19
-
-
37749054886
-
Kif3a constrains beta-catenin-dependent Wnt signaling through dual ciliary and non-ciliary mechanisms
-
Corbit K.C., Shyer A.E., Dowdle W.E., Gaulden J., Singla V., Chen M.H., et al. Kif3a constrains beta-catenin-dependent Wnt signaling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol 2008, 10:70-76.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 70-76
-
-
Corbit, K.C.1
Shyer, A.E.2
Dowdle, W.E.3
Gaulden, J.4
Singla, V.5
Chen, M.H.6
-
20
-
-
65249134946
-
Wnt/beta-catenin signaling promotes renal interstitial fibrosis
-
He W., Dai C., Li Y., Zeng G., Monga S.P., Liu Y. Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 2009, 20:765-776.
-
(2009)
J Am Soc Nephrol
, vol.20
, pp. 765-776
-
-
He, W.1
Dai, C.2
Li, Y.3
Zeng, G.4
Monga, S.P.5
Liu, Y.6
-
21
-
-
28444468088
-
Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis
-
Surendran K., Schiavi S., Hruska K.A. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol 2005, 16:2373-2384.
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 2373-2384
-
-
Surendran, K.1
Schiavi, S.2
Hruska, K.A.3
-
22
-
-
77749246063
-
Macrophage Wnt7b is critical for kidney repair and regeneration
-
Lin S.L., Li B., Rao S., Yeo E.J., Hudson T.E., Nowlin B.T., et al. Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci USA 2010, 107:4194-4199.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 4194-4199
-
-
Lin, S.L.1
Li, B.2
Rao, S.3
Yeo, E.J.4
Hudson, T.E.5
Nowlin, B.T.6
-
23
-
-
69949172478
-
Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy
-
Lancaster M.A., Louie C.M., Silhavy J.L., Sintasath L., Decambre M., Nigam S.K., et al. Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat Med 2009, 15:1046-1054.
-
(2009)
Nat Med
, vol.15
, pp. 1046-1054
-
-
Lancaster, M.A.1
Louie, C.M.2
Silhavy, J.L.3
Sintasath, L.4
Decambre, M.5
Nigam, S.K.6
-
24
-
-
33746037296
-
Wnt/PCP signaling: a veritable polar star in establishing patterns of polarity in embryonic tissues
-
Barrow J.R. Wnt/PCP signaling: a veritable polar star in establishing patterns of polarity in embryonic tissues. Semin Cell Dev Biol 2006, 17:185-193.
-
(2006)
Semin Cell Dev Biol
, vol.17
, pp. 185-193
-
-
Barrow, J.R.1
-
25
-
-
29444450890
-
Defective planar cell polarity in polycystic kidney disease
-
Fischer E., Legue E., Doyen A., Nato F., Nicolas J.F., Torres V., et al. Defective planar cell polarity in polycystic kidney disease. Nat Genet 2006, 38:21-23.
-
(2006)
Nat Genet
, vol.38
, pp. 21-23
-
-
Fischer, E.1
Legue, E.2
Doyen, A.3
Nato, F.4
Nicolas, J.F.5
Torres, V.6
-
26
-
-
67649878597
-
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
-
Karner C.M., Chirumamilla R., Aoki S., Igarashi P., Wallingford J.B., Carroll T.J. Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet 2009, 41:793-799.
-
(2009)
Nat Genet
, vol.41
, pp. 793-799
-
-
Karner, C.M.1
Chirumamilla, R.2
Aoki, S.3
Igarashi, P.4
Wallingford, J.B.5
Carroll, T.J.6
-
27
-
-
48349125616
-
Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease
-
Saburi S., Hester I., Fischer E., Pontoglio M., Eremina V., Gessler M., et al. Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet 2008, 40:1010-1015.
-
(2008)
Nat Genet
, vol.40
, pp. 1010-1015
-
-
Saburi, S.1
Hester, I.2
Fischer, E.3
Pontoglio, M.4
Eremina, V.5
Gessler, M.6
-
28
-
-
50849100989
-
Loss of polycystin-1 causes centrosome amplification and genomic instability
-
Battini L., Macip S., Fedorova E., Dikman S., Somlo S., Montagna C., et al. Loss of polycystin-1 causes centrosome amplification and genomic instability. Hum Mol Genet 2008, 17:2819-2833.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 2819-2833
-
-
Battini, L.1
Macip, S.2
Fedorova, E.3
Dikman, S.4
Somlo, S.5
Montagna, C.6
-
29
-
-
52949115290
-
Centrosome overduplication and mitotic instability in PKD2 transgenic lines
-
Burtey S., Riera M., Ribe E., Pennenkamp P., Rance R., Luciani J., et al. Centrosome overduplication and mitotic instability in PKD2 transgenic lines. Cell Biol Int 2008, 32:1193-1198.
-
(2008)
Cell Biol Int
, vol.32
, pp. 1193-1198
-
-
Burtey, S.1
Riera, M.2
Ribe, E.3
Pennenkamp, P.4
Rance, R.5
Luciani, J.6
-
30
-
-
58149333235
-
The primary cilium at the crossroads of mammalian hedgehog signaling
-
Wong S.Y., Reiter J.F. The primary cilium at the crossroads of mammalian hedgehog signaling. Curr Top Dev Biol 2008, 85:225-260.
-
(2008)
Curr Top Dev Biol
, vol.85
, pp. 225-260
-
-
Wong, S.Y.1
Reiter, J.F.2
-
31
-
-
58749105340
-
Modeling ciliopathies: primary cilia in development and disease
-
Quinlan R.J., Tobin J.L., Beales P.L. Modeling ciliopathies: primary cilia in development and disease. Curr Top Dev Biol 2008, 84:249-310.
-
(2008)
Curr Top Dev Biol
, vol.84
, pp. 249-310
-
-
Quinlan, R.J.1
Tobin, J.L.2
Beales, P.L.3
-
33
-
-
33746597117
-
Control of murine kidney development by sonic hedgehog and its GLI effectors
-
Gill P.S., Rosenblum N.D. Control of murine kidney development by sonic hedgehog and its GLI effectors. Cell Cycle 2006, 5:1426-1430.
-
(2006)
Cell Cycle
, vol.5
, pp. 1426-1430
-
-
Gill, P.S.1
Rosenblum, N.D.2
-
34
-
-
70350217255
-
GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells
-
Cain J.E., Islam E., Haxho F., Chen L., Bridgewater D., Nieuwenhuis E., et al. GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells. PLoS One 2009, 4:e7313.
-
(2009)
PLoS One
, vol.4
-
-
Cain, J.E.1
Islam, E.2
Haxho, F.3
Chen, L.4
Bridgewater, D.5
Nieuwenhuis, E.6
-
35
-
-
33244463281
-
GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
-
Hu M.C., Mo R., Bhella S., Wilson C.W., Chuang P.T., Hui C.C., et al. GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 2006, 133:569-578.
-
(2006)
Development
, vol.133
, pp. 569-578
-
-
Hu, M.C.1
Mo, R.2
Bhella, S.3
Wilson, C.W.4
Chuang, P.T.5
Hui, C.C.6
-
36
-
-
0036860686
-
Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney
-
Yu J., Carroll T.J., McMahon A.P. Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 2002, 129:5301-5312.
-
(2002)
Development
, vol.129
, pp. 5301-5312
-
-
Yu, J.1
Carroll, T.J.2
McMahon, A.P.3
-
37
-
-
0036566575
-
Pallister-Hall syndrome phenotype in mice mutant for Gli3
-
Bose J., Grotewold L., Ruther U. Pallister-Hall syndrome phenotype in mice mutant for Gli3. Hum Mol Genet 2002, 11:1129-1135.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1129-1135
-
-
Bose, J.1
Grotewold, L.2
Ruther, U.3
-
38
-
-
74049138338
-
The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth
-
Dormoy V., Danilin S., Lindner V., Thomas L., Rothhut S., Coquard C., et al. The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth. Mol Cancer 2009, 8:123.
-
(2009)
Mol Cancer
, vol.8
, pp. 123
-
-
Dormoy, V.1
Danilin, S.2
Lindner, V.3
Thomas, L.4
Rothhut, S.5
Coquard, C.6
-
39
-
-
0141905900
-
GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc finger proteins with repressor and activation functions
-
Kim Y.S., Nakanishi G., Lewandoski M., Jetten A.M. GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc finger proteins with repressor and activation functions. Nucleic Acids Res 2003, 31:5513-5525.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 5513-5525
-
-
Kim, Y.S.1
Nakanishi, G.2
Lewandoski, M.3
Jetten, A.M.4
-
40
-
-
0035664006
-
Genomic structure of the gene encoding the human GLI-related, Kruppel-like zinc finger protein GLIS2
-
Zhang F., Jetten A.M. Genomic structure of the gene encoding the human GLI-related, Kruppel-like zinc finger protein GLIS2. Gene 2001, 280:49-57.
-
(2001)
Gene
, vol.280
, pp. 49-57
-
-
Zhang, F.1
Jetten, A.M.2
-
41
-
-
0037155801
-
Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis
-
Zhang F., Nakanishi G., Kurebayashi S., Yoshino K., Perantoni A., Kim Y.S., et al. Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis. J Biol Chem 2002, 277:10139-10149.
-
(2002)
J Biol Chem
, vol.277
, pp. 10139-10149
-
-
Zhang, F.1
Nakanishi, G.2
Kurebayashi, S.3
Yoshino, K.4
Perantoni, A.5
Kim, Y.S.6
-
42
-
-
34547547119
-
Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis
-
Attanasio M., Uhlenhaut N.H., Sousa V.H., O'Toole J.F., Otto E., Anlag K., et al. Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis. Nat Genet 2007, 39:1018-1024.
-
(2007)
Nat Genet
, vol.39
, pp. 1018-1024
-
-
Attanasio, M.1
Uhlenhaut, N.H.2
Sousa, V.H.3
O'Toole, J.F.4
Otto, E.5
Anlag, K.6
-
43
-
-
66349117479
-
Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease
-
Kang H.S., Beak J.Y., Kim Y.S., Herbert R., Jetten A.M. Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease. Mol Cell Biol 2009, 29:2556-2569.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2556-2569
-
-
Kang, H.S.1
Beak, J.Y.2
Kim, Y.S.3
Herbert, R.4
Jetten, A.M.5
-
44
-
-
41149163110
-
Kruppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions
-
Kim Y.S., Kang H.S., Herbert R., Beak J.Y., Collins J.B., Grissom S.F., et al. Kruppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions. Mol Cell Biol 2008, 28:2358-2367.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 2358-2367
-
-
Kim, Y.S.1
Kang, H.S.2
Herbert, R.3
Beak, J.Y.4
Collins, J.B.5
Grissom, S.F.6
-
45
-
-
33745268851
-
Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism
-
Senee V., Chelala C., Duchatelet S., Feng D., Blanc H., Cossec J.C., et al. Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. Nat Genet 2006, 38:682-687.
-
(2006)
Nat Genet
, vol.38
, pp. 682-687
-
-
Senee, V.1
Chelala, C.2
Duchatelet, S.3
Feng, D.4
Blanc, H.5
Cossec, J.C.6
-
46
-
-
33847238440
-
The Kruppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway
-
Kim Y.S., Kang H.S., Jetten A.M. The Kruppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway. FEBS Lett 2007, 581:858-864.
-
(2007)
FEBS Lett
, vol.581
, pp. 858-864
-
-
Kim, Y.S.1
Kang, H.S.2
Jetten, A.M.3
-
47
-
-
34248175228
-
The transcriptional repressor Glis2 is a novel binding partner for p120 catenin
-
Hosking C.R., Ulloa F., Hogan C., Ferber E.C., Figueroa A., Gevaert K., et al. The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol Biol Cell 2007, 18:1918-1927.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 1918-1927
-
-
Hosking, C.R.1
Ulloa, F.2
Hogan, C.3
Ferber, E.C.4
Figueroa, A.5
Gevaert, K.6
-
49
-
-
77950365906
-
Nonresolving inflammation
-
Nathan C., Ding A. Nonresolving inflammation. Cell 2010, 140:871-882.
-
(2010)
Cell
, vol.140
, pp. 871-882
-
-
Nathan, C.1
Ding, A.2
-
50
-
-
55849103960
-
Macrophage diversity in renal injury and repair
-
Ricardo S.D., van Goor H., Eddy A.A. Macrophage diversity in renal injury and repair. J Clin Invest 2008, 118:3522-3530.
-
(2008)
J Clin Invest
, vol.118
, pp. 3522-3530
-
-
Ricardo, S.D.1
van Goor, H.2
Eddy, A.A.3
-
51
-
-
68949207806
-
IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis
-
Bani-Hani A.H., Leslie J.A., Asanuma H., Dinarello C.A., Campbell M.T., Meldrum D.R., et al. IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis. Kidney Int 2009, 76:500-511.
-
(2009)
Kidney Int
, vol.76
, pp. 500-511
-
-
Bani-Hani, A.H.1
Leslie, J.A.2
Asanuma, H.3
Dinarello, C.A.4
Campbell, M.T.5
Meldrum, D.R.6
-
52
-
-
33749024991
-
Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis
-
Sakai N., Wada T., Yokoyama H., Lipp M., Ueha S., Matsushima K., et al. Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis. Proc Natl Acad Sci USA 2006, 103:14098-14103.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 14098-14103
-
-
Sakai, N.1
Wada, T.2
Yokoyama, H.3
Lipp, M.4
Ueha, S.5
Matsushima, K.6
-
53
-
-
48849099770
-
Interleukin-20 targets renal cells and is associated with chronic kidney disease
-
Wei C.C., Li H.H., Hsu Y.H., Hsing C.H., Sung J.M., Chang M.S. Interleukin-20 targets renal cells and is associated with chronic kidney disease. Biochem Biophys Res Commun 2008, 374:448-453.
-
(2008)
Biochem Biophys Res Commun
, vol.374
, pp. 448-453
-
-
Wei, C.C.1
Li, H.H.2
Hsu, Y.H.3
Hsing, C.H.4
Sung, J.M.5
Chang, M.S.6
-
54
-
-
77952556246
-
Suppressors of cytokine signaling abrogate diabetic nephropathy
-
Ortiz-Munoz G., Lopez-Parra V., Lopez-Franco O., Fernandez-Vizarra P., Mallavia B., Flores C., et al. Suppressors of cytokine signaling abrogate diabetic nephropathy. J Am Soc Nephrol 2010.
-
(2010)
J Am Soc Nephrol
-
-
Ortiz-Munoz, G.1
Lopez-Parra, V.2
Lopez-Franco, O.3
Fernandez-Vizarra, P.4
Mallavia, B.5
Flores, C.6
-
55
-
-
77952394844
-
Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations
-
Lin S.L., Castano A.P., Nowlin B.T., Lupher M.L., Duffield J.S. Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations. J Immunol 2009, 183:6733-6743.
-
(2009)
J Immunol
, vol.183
, pp. 6733-6743
-
-
Lin, S.L.1
Castano, A.P.2
Nowlin, B.T.3
Lupher, M.L.4
Duffield, J.S.5
-
56
-
-
0030960574
-
Cytokine profile in autosomal dominant polycystic kidney disease
-
Merta M., Tesar V., Zima T., Jirsa M., Rysava R., Zabka J. Cytokine profile in autosomal dominant polycystic kidney disease. Biochem Mol Biol Int 1997, 41:619-624.
-
(1997)
Biochem Mol Biol Int
, vol.41
, pp. 619-624
-
-
Merta, M.1
Tesar, V.2
Zima, T.3
Jirsa, M.4
Rysava, R.5
Zabka, J.6
-
57
-
-
33644638349
-
Renal fibrosis: new insights into the pathogenesis and therapeutics
-
Liu Y. Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int 2006, 69:213-217.
-
(2006)
Kidney Int
, vol.69
, pp. 213-217
-
-
Liu, Y.1
-
58
-
-
75149174337
-
NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts
-
Bondi C.D., Manickam N., Lee D.Y., Block K., Gorin Y., Abboud H.E., et al. NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts. J Am Soc Nephrol 2010, 21:93-102.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 93-102
-
-
Bondi, C.D.1
Manickam, N.2
Lee, D.Y.3
Block, K.4
Gorin, Y.5
Abboud, H.E.6
-
59
-
-
0029953788
-
Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease
-
Kopp J.B., Factor V.M., Mozes M., Nagy P., Sanderson N., Bottinger E.P., et al. Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease. Lab Invest 1996, 74:991-1003.
-
(1996)
Lab Invest
, vol.74
, pp. 991-1003
-
-
Kopp, J.B.1
Factor, V.M.2
Mozes, M.3
Nagy, P.4
Sanderson, N.5
Bottinger, E.P.6
-
60
-
-
0347993932
-
Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention
-
Liu Y. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004, 15:1-12.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 1-12
-
-
Liu, Y.1
-
61
-
-
0035907240
-
Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach
-
Verrecchia F., Chu M.L., Mauviel A. Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem 2001, 276:17058-17062.
-
(2001)
J Biol Chem
, vol.276
, pp. 17058-17062
-
-
Verrecchia, F.1
Chu, M.L.2
Mauviel, A.3
-
62
-
-
70349409438
-
Positive feedback loop between plasminogen activator inhibitor-1 and transforming growth factor-beta1 during renal fibrosis in diabetes
-
Seo J.Y., Park J., Yu M.R., Kim Y.S., Ha H., Lee H.B. Positive feedback loop between plasminogen activator inhibitor-1 and transforming growth factor-beta1 during renal fibrosis in diabetes. Am J Nephrol 2009, 30:481-490.
-
(2009)
Am J Nephrol
, vol.30
, pp. 481-490
-
-
Seo, J.Y.1
Park, J.2
Yu, M.R.3
Kim, Y.S.4
Ha, H.5
Lee, H.B.6
-
63
-
-
0033736396
-
Transforming growth factor-beta 1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction
-
Isaka Y., Tsujie M., Ando Y., Nakamura H., Kaneda Y., Imai E., et al. Transforming growth factor-beta 1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction. Kidney Int 2000, 58:1885-1892.
-
(2000)
Kidney Int
, vol.58
, pp. 1885-1892
-
-
Isaka, Y.1
Tsujie, M.2
Ando, Y.3
Nakamura, H.4
Kaneda, Y.5
Imai, E.6
-
64
-
-
0034608948
-
Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice
-
Ziyadeh F.N., Hoffman B.B., Han D.C., Iglesias-De La Cruz M.C., Hong S.W., Isono M., et al. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. Proc Natl Acad Sci USA 2000, 97:8015-8020.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 8015-8020
-
-
Ziyadeh, F.N.1
Hoffman, B.B.2
Han, D.C.3
Iglesias-De La Cruz, M.C.4
Hong, S.W.5
Isono, M.6
-
65
-
-
2942535966
-
Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
-
Fukasawa H., Yamamoto T., Togawa A., Ohashi N., Fujigaki Y., Oda T., et al. Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proc Natl Acad Sci USA 2004, 101:8687-8692.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8687-8692
-
-
Fukasawa, H.1
Yamamoto, T.2
Togawa, A.3
Ohashi, N.4
Fujigaki, Y.5
Oda, T.6
-
66
-
-
65249099522
-
Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice
-
Chung A.C., Huang X.R., Zhou L., Heuchel R., Lai K.N., Lan H.Y. Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice. Nephrol Dial Transplant 2009, 24:1443-1454.
-
(2009)
Nephrol Dial Transplant
, vol.24
, pp. 1443-1454
-
-
Chung, A.C.1
Huang, X.R.2
Zhou, L.3
Heuchel, R.4
Lai, K.N.5
Lan, H.Y.6
-
67
-
-
0037566734
-
Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy
-
Fujimoto M., Maezawa Y., Yokote K., Joh K., Kobayashi K., Kawamura H., et al. Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy. Biochem Biophys Res Commun 2003, 305:1002-1007.
-
(2003)
Biochem Biophys Res Commun
, vol.305
, pp. 1002-1007
-
-
Fujimoto, M.1
Maezawa, Y.2
Yokote, K.3
Joh, K.4
Kobayashi, K.5
Kawamura, H.6
-
69
-
-
67650085171
-
TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN
-
Kato M., Putta S., Wang M., Yuan H., Lanting L., Nair I., et al. TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. Nat Cell Biol 2009, 11:881-889.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 881-889
-
-
Kato, M.1
Putta, S.2
Wang, M.3
Yuan, H.4
Lanting, L.5
Nair, I.6
-
70
-
-
58149239731
-
Ski and SnoN, potent negative regulators of TGF-beta signaling
-
Deheuninck J., Luo K. Ski and SnoN, potent negative regulators of TGF-beta signaling. Cell Res 2009, 19:47-57.
-
(2009)
Cell Res
, vol.19
, pp. 47-57
-
-
Deheuninck, J.1
Luo, K.2
-
71
-
-
33646709433
-
Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury
-
Fukasawa H., Yamamoto T., Togawa A., Ohashi N., Fujigaki Y., Oda T., et al. Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury. Kidney Int 2006, 69:1733-1740.
-
(2006)
Kidney Int
, vol.69
, pp. 1733-1740
-
-
Fukasawa, H.1
Yamamoto, T.2
Togawa, A.3
Ohashi, N.4
Fujigaki, Y.5
Oda, T.6
-
72
-
-
77952174830
-
Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
-
1p following 143
-
Yang L., Besschetnova T.Y., Brooks C.R., Shah J.V., Bonventre J.V. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 2010, 16:535-543. 1p following 143.
-
(2010)
Nat Med
, vol.16
, pp. 535-543
-
-
Yang, L.1
Besschetnova, T.Y.2
Brooks, C.R.3
Shah, J.V.4
Bonventre, J.V.5
-
73
-
-
27844595882
-
BMP7 signaling in renal development and disease
-
Patel S.R., Dressler G.R. BMP7 signaling in renal development and disease. Trends Mol Med 2005, 11:512-518.
-
(2005)
Trends Mol Med
, vol.11
, pp. 512-518
-
-
Patel, S.R.1
Dressler, G.R.2
-
74
-
-
69449084178
-
BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition in human renal proximal tubular epithelial cells
-
Xu Y., Wan J., Jiang D., Wu X. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition in human renal proximal tubular epithelial cells. J Nephrol 2009, 22:403-410.
-
(2009)
J Nephrol
, vol.22
, pp. 403-410
-
-
Xu, Y.1
Wan, J.2
Jiang, D.3
Wu, X.4
-
75
-
-
2542441495
-
Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells
-
Wang S., Hirschberg R. Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells. J Biol Chem 2004, 279:23200-23206.
-
(2004)
J Biol Chem
, vol.279
, pp. 23200-23206
-
-
Wang, S.1
Hirschberg, R.2
-
76
-
-
59649093679
-
Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type I transforming growth factor-beta receptors
-
Yang Y.L., Liu Y.S., Chuang L.Y., Guh J.Y., Lee T.C., Liao T.N., et al. Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type I transforming growth factor-beta receptors. Endocrinology 2009, 150:727-740.
-
(2009)
Endocrinology
, vol.150
, pp. 727-740
-
-
Yang, Y.L.1
Liu, Y.S.2
Chuang, L.Y.3
Guh, J.Y.4
Lee, T.C.5
Liao, T.N.6
-
77
-
-
17644378679
-
Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease
-
Lin J., Patel S.R., Cheng X., Cho E.A., Levitan I., Ullenbruch M., et al. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat Med 2005, 11:387-393.
-
(2005)
Nat Med
, vol.11
, pp. 387-393
-
-
Lin, J.1
Patel, S.R.2
Cheng, X.3
Cho, E.A.4
Levitan, I.5
Ullenbruch, M.6
-
78
-
-
33745024718
-
The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia
-
Lin J., Patel S.R., Wang M., Dressler G.R. The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia. Mol Cell Biol 2006, 26:4577-4585.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 4577-4585
-
-
Lin, J.1
Patel, S.R.2
Wang, M.3
Dressler, G.R.4
-
79
-
-
77949745693
-
Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome
-
Tanaka M., Asada M., Higashi A.Y., Nakamura J., Oguchi A., Tomita M., et al. Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome. J Clin Invest 2010, 120:768-777.
-
(2010)
J Clin Invest
, vol.120
, pp. 768-777
-
-
Tanaka, M.1
Asada, M.2
Higashi, A.Y.3
Nakamura, J.4
Oguchi, A.5
Tomita, M.6
-
80
-
-
76049128716
-
Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models
-
Cao Y., Semanchik N., Lee S.H., Somlo S., Barbano P.E., Coifman R., et al. Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. Proc Natl Acad Sci USA 2009, 106:21819-21824.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 21819-21824
-
-
Cao, Y.1
Semanchik, N.2
Lee, S.H.3
Somlo, S.4
Barbano, P.E.5
Coifman, R.6
-
81
-
-
69449107940
-
Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury
-
Noh H., Oh E.Y., Seo J.Y., Yu M.R., Kim Y.O., Ha H., et al. Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. Am J Physiol Renal Physiol 2009, 297:F729-F739.
-
(2009)
Am J Physiol Renal Physiol
, vol.297
-
-
Noh, H.1
Oh, E.Y.2
Seo, J.Y.3
Yu, M.R.4
Kim, Y.O.5
Ha, H.6
-
82
-
-
66049156204
-
Renal ischemia-reperfusion injury upregulates histone-modifying enzyme systems and alters histone expression at proinflammatory/profibrotic genes
-
Zager R.A., Johnson A.C. Renal ischemia-reperfusion injury upregulates histone-modifying enzyme systems and alters histone expression at proinflammatory/profibrotic genes. Am J Physiol Renal Physiol 2009, 296:F1032-F1041.
-
(2009)
Am J Physiol Renal Physiol
, vol.296
-
-
Zager, R.A.1
Johnson, A.C.2
-
83
-
-
77952116121
-
Methylation determines fibroblast activation and fibrogenesis in the kidney
-
Bechtel W., McGoohan S., Zeisberg E.M., Muller G.A., Kalbacher H., Salant D.J., et al. Methylation determines fibroblast activation and fibrogenesis in the kidney. Nat Med 2010.
-
(2010)
Nat Med
-
-
Bechtel, W.1
McGoohan, S.2
Zeisberg, E.M.3
Muller, G.A.4
Kalbacher, H.5
Salant, D.J.6
-
84
-
-
77955205559
-
Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus
-
Bell C.G., Teschendorff A.E., Rakyan V.K., Maxwell A.P., Beck S., Savage D.A. Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus. BMC Med Genomics 2010, 3:33.
-
(2010)
BMC Med Genomics
, vol.3
, pp. 33
-
-
Bell, C.G.1
Teschendorff, A.E.2
Rakyan, V.K.3
Maxwell, A.P.4
Beck, S.5
Savage, D.A.6
-
85
-
-
34247863920
-
PVHL and GSK3beta are components of a primary cilium-maintenance signaling network
-
Thoma C.R., Frew I.J., Hoerner C.R., Montani M., Moch H., Krek W. pVHL and GSK3beta are components of a primary cilium-maintenance signaling network. Nat Cell Biol 2007, 9:588-595.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 588-595
-
-
Thoma, C.R.1
Frew, I.J.2
Hoerner, C.R.3
Montani, M.4
Moch, H.5
Krek, W.6
-
86
-
-
67349203626
-
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
-
van Haaften G., Dalgliesh G.L., Davies H., Chen L., Bignell G., Greenman C., et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet 2009, 41:521-523.
-
(2009)
Nat Genet
, vol.41
, pp. 521-523
-
-
van Haaften, G.1
Dalgliesh, G.L.2
Davies, H.3
Chen, L.4
Bignell, G.5
Greenman, C.6
-
87
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
Dalgliesh G.L., Furge K., Greenman C., Chen L., Bignell G., Butler A., et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 2010, 463:360-363.
-
(2010)
Nature
, vol.463
, pp. 360-363
-
-
Dalgliesh, G.L.1
Furge, K.2
Greenman, C.3
Chen, L.4
Bignell, G.5
Butler, A.6
-
88
-
-
71449100603
-
Strategies for TGF-beta modulation: a review of recent patents
-
Bonafoux D., Lee W.C. Strategies for TGF-beta modulation: a review of recent patents. Expert Opin Ther Pat 2009, 19:1759-1769.
-
(2009)
Expert Opin Ther Pat
, vol.19
, pp. 1759-1769
-
-
Bonafoux, D.1
Lee, W.C.2
|