Synthesis of pyrrole-imidazole polyamide seco -1-chloromethyl-5-hydroxy-1, 2-dihydro-3 H -benz[ e ]indole conjugates with a vinyl linker recognizing a 7 bp DNA sequence

Journal of the American Chemical Society

Volumn 134, Issue 31, 2012, Pages 13074-13081

  Takagaki, Toshiki ^a   Bando, Toshikazu ^a   Sugiyama, Hiroshi ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING ACTIVITY; CYCLOPROPANE RING; DISTORTED GEOMETRY; DNA FRAGMENT; GEL ELECTROPHORESIS; HIGH RESOLUTION; LIQUID PHASE; MOLECULAR MODELING STUDIES; N-METHYLIMIDAZOLE; N-METHYLPYRROLE; NANOMOLAR CONCENTRATION; PRODUCT ANALYSIS; PYRROLE RING; PYRROLE-IMIDAZOLE POLYAMIDES; S-ENANTIOMERS; SOLID PHASE PEPTIDE SYNTHESIS; STERIC HINDRANCES; SUBSTITUENT EFFECT; SYNTHETIC ROUTES; VINYL GROUP;

ALKYLATION; DENSITY FUNCTIONAL THEORY; DNA; DNA SEQUENCES; ELECTROPHORESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; OLIGOMERS; OLIGONUCLEOTIDES; PROPANE;

BROMINE COMPOUNDS;

IMIDAZOLE DERIVATIVE; POLYAMIDE; PYRROLE DERIVATIVE; SECO 1 CHLOROMETHYL 5 HYDROXY 1,2 DIHYDRO 3H BENZ[E]INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DENATURING GRADIENT GEL ELECTROPHORESIS; DENSITY FUNCTIONAL THEORY; DNA ALKYLATION; DNA SEQUENCE; DRUG ACTIVITY; DRUG SYNTHESIS; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR MODEL; RACEMIC MIXTURE; STEREOSPECIFICITY;

ALKYLATING AGENTS; ALKYLATION; BASE PAIRING; BASE SEQUENCE; DNA; DNA ADDUCTS; IMIDAZOLES; INDOLES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NYLONS; OLIGONUCLEOTIDES; SOLID-PHASE SYNTHESIS TECHNIQUES; VINYL COMPOUNDS;

EID: 84864657711     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3044294     Document Type: Article

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