Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes

British Journal of Pharmacology

Volumn 167, Issue 1, 2012, Pages 67-79

  Kaneva, Magdalena K ^a   Kerrigan, Mark J P ^b   Grieco, Paolo ^c   Curley, G Paul ^a   Locke, Ian C ^a   Getting, Stephen J ^a  

^a UNIVERSITY OF WESTMINSTER   (United Kingdom)

^b UNIVERSITY OF GREENWICH   (United Kingdom)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

anti inflammatory; apoptosis; caspases; chemokines; chondrocyte; chondroprotective; cytokines; GPCR; melanocortins; MMPs

Indexed keywords

[DTRP8] GAMMA INTERMEDIN; ALPHA INTERMEDIN; CASPASE 3; CASPASE 7; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MATRIX METALLOPROTEINASE; MELANOCORTIN; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 3 RECEPTOR; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; PEPTIDE DERIVATIVE; PROTEINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL DEATH; CHONDROPROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MMP1 GENE; MMP13 GENE; MMP3 GENE; PRIORITY JOURNAL; PROTEIN FUNCTION;

ALPHA-MSH; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CASPASE 3; CASPASE 7; CELL LINE; CELL SURVIVAL; CHONDROCYTES; CYCLIC AMP; CYTOKINES; DINOPROSTONE; GAMMA-MSH; HUMANS; MATRIX METALLOPROTEINASES; MELANOCYTE-STIMULATING HORMONES; PROTECTIVE AGENTS; RECEPTOR, MELANOCORTIN, TYPE 1; RECEPTOR, MELANOCORTIN, TYPE 3;

EID: 84864652059     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01968.x     Document Type: Article

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