The polyamine analogue N1,N11-diethylnorspermine can induce chondrocyte apoptosis independently of its ability to alter metabolism and levels of natural polyamines

Journal of Cellular Physiology

Volumn 219, Issue 1, 2009, Pages 109-116

  Stanic, Ivana ^a   Facchini, Annalisa ^a   Borzì, Rosa Maria ^b   Stefanelli, Claudio ^a   Flamigni, Flavio ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; CYCLOHEXIMIDE; ENZYME INHIBITOR; N1,N11 DIETHYLNORSPERMINE; POLYAMINE DERIVATIVE; POLYAMINE OXIDASE; RECOMBINANT TUMOR NECROSIS FACTOR; SPERMIDINE DERIVATIVE; SPERMINE DERIVATIVE; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; N(1),N(11) DIETHYLNORSPERMINE; N(1),N(11)-DIETHYLNORSPERMINE; POLYAMINE; PROTEIN SYNTHESIS INHIBITOR; SPERMINE;

APOPTOSIS; ARTICLE; CARTILAGE CELL; CATABOLISM; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; POLYAMINE METABOLISM; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; CELL LINE; CYTOLOGY; GENETICS; METABOLISM; PHYSIOLOGY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE; CHONDROCYTES; CYCLOHEXIMIDE; ENZYME ACTIVATION; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; POLYAMINES; PROTEIN SYNTHESIS INHIBITORS; SIGNAL TRANSDUCTION; SPERMINE;

EID: 60849133029     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21655     Document Type: Article

References (37)

1. Allen WL, McLean EG, Boyer J, McCulla A, Wilson PM, Coyle V, Longley DB, Casero RA, Jr., Johnston PG. 2007. The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells. Mol Cancer Ther 6:128-137.
2. Bachrach U, Wang YC, Tabib A. 2001. Polyamines: New cues in cellular signal transduction. News Physiol Sci 16:106-109.
3. Bhattacharya S, Ray RM, Johnson LR. 2006. Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. Biochem J 397:437-447.
4. Casero RA, Jr., Marton LJ. 2007. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov 6:373-390.
5. Chen Y, Kramer DL, Diegelman P, Vujcic S, Porter CW. 2001. Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells. Cancer Res 61:6437-6444.
6. Chen Y, Alm K, Vujcic S, Kramer DL, Kee K, Diegelman P, Porter CW. 2003a. The role of mitogen-activated protein kinase activation in determining cellular outcomes in polyamine analogue-treated human melanoma cells. Cancer Res 63:3619-3625.
7. Chen Y, Kramer DL, Jell J, Vujcic S, Porter CW. 2003b. Small interfering RNA suppression of polyamine analog-induced spermidine/spermine n1-acetyltransferase. Mol Pharmacol 64:1153-1159.
8. Chen Y, Kramer DL, Li F, Porter CW. 2003c. Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells. Oncogene 22:4964-4972.
9. Choi W, Gerner EW, Ramdas L, Dupart J, Carew J, Proctor L, Huang P, Zhang W, Hamilton SR. 2005. Combination of 5-fluorouracil and N1,N11- diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells. J Biol Chem 280:3295-3304.
10. Choi W, Proctor L, Xia Q, Feng Y, Gerner EW, Chiao PJ, Hamilton SR, Zhang W. 2006. Inactivation of IkappaB contributes to transcriptional activation of spermidine/spermine N(1)-acetyltransferase. Mol Carcinog 45:685-693.
11. Devereux W, Wang Y, Stewart TM, Hacker A, Smith R, Frydman B, Valasinas AL, Reddy VK, Marton LJ, Ward TD, Woster PM, Casero RA. 2003. Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. Cancer Chemother Pharmacol 52:383-390.
12. Finger F, Schorle C, Zien A, Gebhard P, Goldring MB, Aigner T. 2003. Molecular phenotyping of human chondrocyte cell lines T/C-28a2, T/C-28a4, and C-28/I2. Arthritis Rheum 48:3395-3403.
13. Flamigni F, Campana G, Carboni L, Guarnieri C, Spampinato S. 1994. Zinc is required for the expression of ornithine decarboxylase in a difluoromethylornithine-resistant cell line. Biochem J 299:515-519.
14. Flamigni F, Stanic I, Facchini A, Cetrullo S, Tantini B, Borzi RM, Guarnieri C, Caldarera CM. 2007. Polyamine biosynthesis as a target to inhibit apoptosis of non-tumoral cells. Amino Acids 33:197-202.
15. Gerner EW, Meyskens FL, Jr. 2004. Polyamines and cancer: Old molecules, new understanding. Nat Rev Cancer 4:781-792.
16. Goggs R, Carter SD, Schulze-Tanzil G, Shakibaei M, Mobasheri A. 2003. Apoptosis and the loss of chondrocyte survival signals contribute to articular cartilage degradation in osteoarthritis. Vet J 166:140-158.
17. Hegardt C, Johannsson OT, Oredsson SM. 2002. Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)- diethylnorspermine. Eur J Biochem 269:1033-1039.
18. Hu RH, Pegg AE. 1997. Rapid induction of apoptosis by deregulated uptake of polyamine analogues. Biochem J 328:307-316.
19. Jiang R, Choi W, Hu L, Gerner EW, Hamilton SR, Zhang W. 2007a. Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells. Cancer Biol Ther 6:1644-1648.
20. Jiang R, Choi W, Khan A, Hess K, Gerner EW, Casero RA, Jr., Yung WK, Hamilton SR, Zhang W. 2007b. Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma. Int J Oncol 31:431-440.
21. Kohli M, Jorgensen TJ. 1999. The influence of SV40 immortalization of human fibroblasts on p53-dependent radiation responses. Biochem Biophys Res Commun 257:168-176.
22. Kramer DL, Vujcic S, Diegelman P, Alderfer J, Miller JT, Black JD, Bergeron RJ, Porter CW. 1999. Polyamine analogue induction of the p53-p21WAF1/CIP1-Rb pathway and G1 arrest in human melanoma cells. Cancer Res 59:1278-1286.
23. Kuhn K, D'Lima DD, Hashimoto S, Lotz M. 2004. Cell death in cartilage. Osteoarthritis Cartilage 12:1-16.
24. Marverti G, Monti MG, Bettuzzi S, Caporali A, Astancolle S, Moruzzi MS. 2004. Cisplatin- resistance modulates the effect of protein synthesis inhibitors on spermidine/spermine N(1)-acetyltransferase expression. Int J Biochem Cell Biol 36:123-137.
25. Mitchell JL, Leyser A, Holtorff MS, Bates JS, Frydman B, Valasinas AL, Reddy VK, Marton LJ. 2002. Antizyme induction by polyamine analogues as a factor of cell growth inhibition. Biochem J 366:663-671.
26. Mitchell JL, Simkus CL, Thane TK, Tokarz P, Bonar MM, Frydman B, Valasinas AL, Reddy VK, Marton LJ. 2004. Antizyme induction mediates feedback limitation of the incorporation of specific polyamine analogues in tissue culture. Biochem J 384:271-279.
27. Oredsson SM, Alm K, Dahlberg E, Holst CM, Johansson VM, Myhre L, Soderstjerna E. 2007. Inhibition of cell proliferation and induction of apoptosis by N(1),N(11)- diethylnorspermine-induced polyamine pool reduction. Biochem Soc Trans 35:405-409.
28. Penning LC, Schipper RG, Vercammen D, Verhofstad AA, Denecker T, Beyaert R, Vandenabeele P. 1998. Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines. Cytokine 10:423-431.
29. Pignatti C, Tantini B, Stefanelli C, Flamigni F. 2004. Signal transduction pathways linking polyamines to apoptosis. Amino Acids 27:359-365.
30. Pledgie A, Huang Y, Hacker A, Zhang Z, Woster PM, Davidson NE, Casero RA, Jr. 2005. Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines. J Biol Chem 280:39843-39851.
31. Seiler N. 2003. Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect. Part 2. Structural analogues and derivatives. Curr Drug Targets 4:565-585.
32. Seiler N, Raul F. 2005. Polyamines and apoptosis. J Cell Mol Med 9:623-642.
33. Stanic I, Facchini A, Borzi RM, Vitellozzi R, Stefanelli C, Goldring MB, Guarnieri C, Facchini A, Flamigni F. 2006. Polyamine depletion inhibits apoptosis following blocking of survival pathways in human chondrocytes stimulated by tumor necrosis factor-alpha. J Cell Physiol 206:138-146.
34. Stanic I, Cetrullo S, Facchini A, Stefanelli C, Borzi RM, Tantini B, Guarnieri C, Caldarera CM, Flamigni F. 2008. Effect of the polyamine analogue N(1),N(11)-diethylnorspermine on cell survival and susceptibility to apoptosis of human chondrocytes. J Cell Physiol 216:153-161.
35. Stefanelli C, Pignatti C, Tantini B, Fattori M, Stanic I, Mackintosh CA, Flamigni F, Guarnieri C, Caldarera CM, Pegg AE. 2001. Effect of polyamine depletion on caspase activation: A study with spermine synthase-deficient cells. Biochem J 355:199-206.
36. Wang Y, Casero RA, Jr. 2006. Mammalian polyamine catabolism: A therapeutic target, a pathological problem, or both? J Biochem (Tokyo) 139:17-25.
37. Widmann C, Gibson S, Johnson GL. 1998. Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals. J Biol Chem 273:7141-7147.