Myricetin protects against cytokine-induced cell death in RIN-m5f β cells

Journal of Medicinal Food

Volumn 15, Issue 8, 2012, Pages 733-740

  Ding, Ye ^a   Zhang, Zhao Feng ^a   Dai, Xiao Qian ^a   Li, Yong ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

cytokines; mitochondrial death pathway; myricetin; nuclear factor B; RIN m5f cells

Indexed keywords

CYTOCHROME C; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MYRICETIN; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL LINE; CELL PROTECTION; CELL VIABILITY; CONCENTRATION (PARAMETERS); INSULIN RELEASE; MITOCHONDRION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN SUBUNIT;

APOPTOSIS; CELL LINE, TUMOR; CYTOCHROMES C; FLAVONOIDS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; MITOCHONDRIA; NITRIC OXIDE; PROTECTIVE AGENTS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84864597323     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2011.2033     Document Type: Article

References (39)

1. Eizirik DL, Mandrup-Poulsen T: A choice of death: The signaltransduction of immune-mediated b-cell apoptosis. Diabetologia 2001;44:2115-2133.
2. Delaney CA, Pavlovic D, Hoorens A, Pipeleers DG, Eizirik DL: Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 1997;138:2610-2614.
3. Mandrup-Poulsen T: Apoptotic signal transduction pathways in diabetes. Biochem Pharmacol 2003;66:1433-1440.
4. Guest CB, Park MJ, Johnson DR, Freund GG: The implication of proinflammatory cytokines in type 2 diabetes. Front Biosci 2008; 13:5187-5194.
5. Eizirik DL, Moore F, Flamez D, Ortis F: Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes. Biochem Soc Trans 2008;36:321-327.
6. Corbett JA, Wang JL, Sweetland MA, Lancaster JR Jr, McDaniel ML: Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide. J Clin Invest 1992;90:2384-2391.
7. Szabadkai G, Duchen MR: Mitochondria mediated cell death in diabetes. Apoptosis 2009;14:1405-1423.
8. Harnly JM, Doherty RF, Beecher GR, et al.: Flavonoid content of U.S. fruits, vegetables, and nuts. J Agric Food Chem 2006;54: 9966-9977.
9. Mira L, Fernandez MT, Santos M, Rocha R, Florencio MH, Jennings KR: Interactions of flavonoids with iron and copper ions: A mechanism for their antioxidant activity. Free Radic Res 2002;36:1199-1120.
10. Cushnie TP, Lamb AJ: Antimicrobial activity of flavonoids. Int J Antimicrob Agents 2005;26:343-356.
11. Kang NJ, Jung SK, Lee KW, Lee HJ: Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis. Ann NY Acad Sci 2011;1229:124-132.
12. Ong KC, Khoo HE: Effects of myricetin on glycemia and glycogen metabolism in diabetic rats. Life Sci 2000;67: 1695-1705.
13. Liu IM, Tzeng TF, Liou SS, Lan TW: Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats. Life Sci 2007;81:1479-1488.
14. Liu IM, Tzeng TF, Liou SS, Lan TW: Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta Med 2007;73:1054-1060.
15. Ahrens MJ, Thompson DL: Composition and method for treating diabetes and metabolic disorders. U.S. Patent Application 2008/0234364 A1. September 25, 2008.
16. Mazed MA, Linda Y, Mazed S: Nutritional supplement for the prevention of cardiovascular disease, Alzheimer's disease, diabetes, and regulation and reduction of blood sugar and insulin resistance. U.S. Patent Application 2009/0252796 A1. October 8, 2009.
17. Blonska M, Czuba ZP, Krol W: Effect of flavone derivatives on interleukin-1b (IL-1b) mRNA expression and IL-1b protein synthesis in stimulated RAW 264.7 macrophages. Scand J Immunol 2003;57:162-166.
18. Lee YS, Choi EM: Myricetin inhibits IL-1beta-induced inflammatory mediators in SW982 human synovial sarcoma cells. Int Immunopharmacol 2010;10:812-814.
19. Kuo PL: Myricetin inhibits the induction of anti-Fas IgM-, tumor necrosis factor-a- and interleukin-1b-mediated apoptosis by Fas pathway inhibition in human osteoblastic cell line MG-63. Life Sci 2005;77:2964-2976.
20. Zhang Z, Ding Y, Dai X, Wang J, Li Y: Epigallocatechin-3- gallate protects pro-inflammatory cytokine induced injuries in insulin-producing cells through the mitochondrial pathway. Eur J Pharmacol 2011;670:311-316.
21. Aherne SA, O'Brien NM: Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and HepG2 cells. Nutr Cancer 1999;34: 160-166.
22. Wang LW, Liu FZ, Lu JK, Liu YC, Yang BF: Effect of flavonols on caspase-3, Bcl-2 and Bax expression in cardiomyocytes apoptosis. Chin Pharm J 2007;42:749-753.
23. Zwolak P, Borja-Cacho D, Phillips PA, et al.: Myricetin induces apoptosis via caspase activation and inhibition of PI-3 kinase/Akt and Erk pathways in human pancreatic cells. Pancreas 2007; 35:439.
24. Phillips PA, Sangwan V, Borja-Cacho D, Dudeja V, Vickers SM, Saluja AK: Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway. Cancer Lett 2011;308:181-188.
25. Heimberg H, Heremans Y, Jobin C, et al.: Inhibition of cytokineinduced NF-jB activation by adenovirus-mediated expression of a NF-jB super-repressor prevents b-cell apoptosis. Diabetes 2001;50:2219-2224.
26. Eldor R, Yeffet A, Baum K, et al.: Conditional and specific NFjB blockade protects pancreatic b cells from diabetogenic agents. Proc Natl Acad Sci USA 2006;103:5072-5077.
27. Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL: Free fatty acids and cytokines induce pancreatic bcell apoptosis by different mechanisms: Role of nuclear factor-jB and endoplasmic reticulum stress. Endocrinology 2004;145: 5087-5096.
28. Darville MI, Eizirik DL: Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Diabetologia 1998;41:1101-1108.
29. Rostoka E, Baumane L, Isajevs S, et al.: Effects of kaempferol and myricetin on inducible nitric oxide synthase expression and nitric oxide production in rats. Basic Clin Pharmacol Toxicol 2010;106:461-466.
30. Kanitkar M, Gokhale K, Galande S, Bhonde RR: Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo. Br J Pharmacol 2008;155:702-713.
31. Chen F, Zhou XH, Lin Y, et al.: Resveratrol prevents interleukin- 1b-induced dysfunction of pancreatic b-cells. J Biomed Res 2010;24:381-388.
32. Song MY, Jeong GS, Kwon KB, et al.: Sulfuretin protects against cytokine-induced b-cell damage and prevents streptozotocininduced diabetes. Exp Mol Med 2010;42:628-638.
33. Grunnet LG, Aikin R, Tonnesen MF, et al.: Proinflammatory cytokines activate the intrinsic apoptotic pathway in b-cells. Diabetes 2009;58:1807-1815.
34. Kim WH, Lee JW, Gao B, Jung MH: Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: Apoptosis of pancreatic beta-cells via the p53 and ROS pathway. Cell Signal 2005;17:1516-1532.
35. Pandey KB, Mishra N, Rizvi SI: Myricetin may provide protection against oxidative stress in type 2 diabetic erythrocytes. Z Naturforsch C 2009;64:626-630.
36. Lee KH, Choi EM: Myricetin, a naturally occurring flavonoid, prevents 2-deoxy-d-ribose induced dysfunction and oxidative damage in osteoblastic MC3T3-E1 cells. Eur J Pharmacol 2008; 591:1-6.
37. Zhang K, Ma Z, Wang J, Xie A, Xie J: Myricetin attenuated MPP+ -induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK activation in MES23.5 cells. Neuropharmacology 2011;61:329-335.
38. Pandey KB, Mishra N, Rizvi SI: Myricetin can mitigate altered redox status in type 2 diabetic erythrocytes. http://pubcouncil .kuniv.edu.kw (accessed May 2010)
39. Nirmala P, Ramanathan M: Effect of myricetin on 1,2 dimethylhydrazine induced rat colon carcinogenesis. J Exp Ther Oncol 2011;9:101-108.