Expression of cytosolic branched chain aminotransferase (BCATc) mRNA in the developing mouse brain

Gene Expression Patterns

Volumn 7, Issue 4, 2007, Pages 485-490

  Castellano, Stefania ^a   Casarosa, Simona ^b   Sweatt, Andrew J ^c   Hutson, Susan M ^c   Bozzi, Yuri ^a  

^a CNR Consiglio Nazionale delle Ricerche   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Brainstem; Branched chain aminoacid; Central nervous system; Cerebellum; Cerebral cortex; GABA; Glutamate; Habenula; Hippocampus; Interneuron; Pontine nuclei; Precerebellar system; Pyramidal neurons; Raphe; Substantia nigra; Thalamus

Indexed keywords

BRANCHED CHAIN AMINO ACID AMINOTRANSFERASE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; CEREBELLUM CORTEX; CONTROLLED STUDY; CYTOSOL; DEVELOPMENTAL STAGE; EMBRYO; ENZYME ANALYSIS; ENZYME LOCALIZATION; FEMALE; GENE EXPRESSION PROFILING; GENETIC CODE; GESTATIONAL AGE; HIPPOCAMPUS; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAPHE NUCLEUS; THALAMUS;

ANIMALS; BRAIN; CYTOSOL; EMBRYO; FEMALE; GENE EXPRESSION; MALE; MICE; MICE, INBRED C57BL; RNA, MESSENGER; TRANSAMINASES;

RODENTIA;

EID: 33846595684     PISSN: 1567133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.modgep.2006.10.010     Document Type: Article

References (19)

1. Casarosa S., Fode C., and Guillemot F. Mash1 regulates neurogenesis in the ventral telencephalon. Development 126 (1999) 525-534
2. Castellano S., Macchi F., Scali M., Huang J.Z., and Bozzi Y. Cytosolic branched chain aminotransferase (BCATc) mRNA is up-regulated in restricted brain areas of BDNF transgenic mice. Brain Res. 1108 (2006) 12-18
3. Daikhin Y., and Yudkoff M. Compartmentation of brain glutamate metabolism in neurons and glia. J. Nutr. 130 (2000) 1026S-1031S
4. Franklin K.B.J., and Paxinos G. The Mouse Brain in Stereotaxic Coordinates (1997), Academic Press Inc., San Diego
5. Garcia-Espinosa, M.A., Wallin, R., Hutson, S.M., Sweatt, A.J., in press. Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signalling by amino acids. J. Neurochem.
6. Hall T.R., Wallin R., Reinhart G.D., and Hutson S.M. Branched chain aminotransferase isoenzymes. Purification and characterization of the rat brain isoenzyme. J. Biol. Chem. 268 (1993) 3092-3098
7. Hutson S.M. Subcellular distribution of branched-chain aminotransferase activity in rat tissues. J. Nutr. 118 (1988) 1475-1481
8. Hutson S.M., Berkich D., Drown P., Xu B., and LaNoue F. Role of branched chain aminotransferase isoenzymes and gabapentin in neurotransmitter metabolism. J. Neurochem. 71 (1998) 863-874
9. Hutson S.M., Lieth E., and LaNoue K.F. Function of leucine in excitatory neurotransmitter metabolism in the central nervous system. J. Nutr. 131 (2001) 846S-850S
10. Hutson S.M., Wallin R., and Hall T.R. Identification of mitochondrial branched chain aminotransferase and its isoforms in rat tissues. J. Biol. Chem. 267 (1992) 15681-15686
11. Ichihara A. Aminotransferases of branched-chain amino acids. In: Christen P., and Metzler D.E. (Eds). Transaminases (1985), Wiley and Sons, New York 430-438
12. Ichihara A., and Koyama E. Transaminase of branched chain amino acids. I. Branched chain amino acids-alpha-ketoglutarate transaminase. J. Biochem. 59 (1966) 160-169
13. Jacobowitz D.M., and Abbott L.C. Chemoarchitectonic Atlas of the Developing Mouse Brain (1998), CRC Press, Boca Raton
14. Kholodilov N.G., Neystat M., Oo T.F., Hutson S.M., and Burke R.E. Upregulation of cytosolic branched chain aminotransferase in substantia nigra following developmental striatal target injury. Brain Res. Mol. Brain Res. 75 (2000) 281-286
15. LaNoue K.F., Berkich D.A., Conway M., Barber A.J., Hu L.-Y., Taylor C., and Hutson S.M. Role of specific aminotransferases in de novo glutamate synthesis and redox shuttling in the retina. J. Neurosci. Res. 66 (2001) 914-922
16. Madeddu F., Naska S., Menna E., Chiellini C., Sweatt A.J., Hutson S.M., Benzi L., Maffei M., Maffei L., and Bozzi Y. Intraocular delivery of BDNF following visual cortex lesion up-regulates cytosolic branched chain aminotransferase (BCATc) in the rat dorsal lateral geniculate nucleus. Eur. J. Neurosci. 20 (2004) 580-586
17. Schambra U.B., Lauder J.M., and Silver J. Atlas of the Prenatal Mouse Brain (1992), Academic Press Inc., San Diego
18. Sweatt A.J., Garcia-Espinosa M.A., Wallin R., and Hutson S.M. Branched-chain amino acids and neurotransmitter metabolism: expression of cytosolic branched-chain aminotransferase (BCATc) in the cerebellum and hippocampus. J. Comp. Neurol. 477 (2004) 360-370
19. Yudkoff M. Brain metabolism of branched-chain amino acids. Glia 21 (1997) 92-98