메뉴 건너뛰기




Volumn 68, Issue 1, 1998, Pages 72-81

A molecular model of human branched-chain amino acid metabolism

Author keywords

African green monkeys; Branched chain amino acid; Branched chain keto acid dehydrogenase kinase; Branched chain keto acid dehydrogenase; Branched chainamino acid aminotransferase; Essential amino acids; Human models; Metabolism; Rats

Indexed keywords

2 OXOACID; BRANCHED CHAIN AMINO ACID;

EID: 0031750339     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/68.1.72     Document Type: Article
Times cited : (328)

References (49)
  • 3
    • 0023853190 scopus 로고
    • Role of mitochondrial transamination in branched chain amino acid metabolism
    • Hutson SM, Fenstermacher D, Mahar C. Role of mitochondrial transamination in branched chain amino acid metabolism. J Biol Chem 1988;263:3618-25.
    • (1988) J Biol Chem , vol.263 , pp. 3618-3625
    • Hutson, S.M.1    Fenstermacher, D.2    Mahar, C.3
  • 4
    • 0027523237 scopus 로고
    • Identification of the mitochondrial branched chain aminotransferase as a branched chain α-keto acid transport protein
    • Hutson SM, Hall TR. Identification of the mitochondrial branched chain aminotransferase as a branched chain α-keto acid transport protein. J Biol Chem 1993;268:3084-91.
    • (1993) J Biol Chem , vol.268 , pp. 3084-3091
    • Hutson, S.M.1    Hall, T.R.2
  • 5
    • 0026664229 scopus 로고
    • Identification of mitochondrial branched chain aminotransferase and its isoforms in rat tissues
    • Hutson SM, Wallin R, Hall TR. Identification of mitochondrial branched chain aminotransferase and its isoforms in rat tissues. J Biol Chem 1992;267:15681-6.
    • (1992) J Biol Chem , vol.267 , pp. 15681-15686
    • Hutson, S.M.1    Wallin, R.2    Hall, T.R.3
  • 6
    • 0027408857 scopus 로고
    • Branched chain aminotransferase isoenzymes: Purification and characterization of the rat brain isoenzyme
    • Hall TR, Wallin R, Hutson SM. Branched chain aminotransferase isoenzymes: purification and characterization of the rat brain isoenzyme. J Biol Chem 1993;268:3092-8.
    • (1993) J Biol Chem , vol.268 , pp. 3092-3098
    • Hall, T.R.1    Wallin, R.2    Hutson, S.M.3
  • 7
    • 0001106274 scopus 로고
    • Disorders of branched chain amino acid and keto acid metabolism
    • Schriver CR, Beaudet AL, Sly WS, Valle D, eds. New York: McGraw-Hill
    • Chuang DT, Shih VE. Disorders of branched chain amino acid and keto acid metabolism. In: Schriver CR, Beaudet AL, Sly WS, Valle D, eds. The metabolic basis of inherited disease. New York: McGraw-Hill, 1995:1239-77.
    • (1995) The Metabolic Basis of Inherited Disease , pp. 1239-1277
    • Chuang, D.T.1    Shih, V.E.2
  • 8
    • 0026772495 scopus 로고
    • Branched-chain α-ketoacid dehydrogenase kinase: Molecular cloning, expression, and sequence similarity with histidine protein kinases
    • Popov KM, Zhao Y, Shimomura Y, Kuntz MJ, Harris RA. Branched-chain α-ketoacid dehydrogenase kinase: molecular cloning, expression, and sequence similarity with histidine protein kinases. J Biol Chem 1992;267:13127-30.
    • (1992) J Biol Chem , vol.267 , pp. 13127-13130
    • Popov, K.M.1    Zhao, Y.2    Shimomura, Y.3    Kuntz, M.J.4    Harris, R.A.5
  • 9
    • 0000764699 scopus 로고
    • Aminotransferases of branched-chain amino acids
    • Christen P, Metzler DE, eds. New York: John Wiley & Sons
    • Ichihara A. Aminotransferases of branched-chain amino acids. In: Christen P, Metzler DE, eds. Transaminases. Vol 2. New York: John Wiley & Sons, 1985:430-8.
    • (1985) Transaminases , vol.2 , pp. 430-438
    • Ichihara, A.1
  • 10
    • 0023243288 scopus 로고
    • Modulation of rat skeletal muscle branched-chain α-keto acid dehydrogenase
    • Block KP, Aftring RP, Buse MG. Modulation of rat skeletal muscle branched-chain α-keto acid dehydrogenase. J Clin Invest 1987;252:1349-58.
    • (1987) J Clin Invest , vol.252 , pp. 1349-1358
    • Block, K.P.1    Aftring, R.P.2    Buse, M.G.3
  • 11
    • 0024269465 scopus 로고
    • Determination of activity and activity stale of branched chain α-keto acid dehydrogenase in rat tissues
    • Goodwin GW, Zhang B, Paxton R, Harris RA. Determination of activity and activity stale of branched chain α-keto acid dehydrogenase in rat tissues. Methods Enzymol 1988;166:189-201.
    • (1988) Methods Enzymol , vol.166 , pp. 189-201
    • Goodwin, G.W.1    Zhang, B.2    Paxton, R.3    Harris, R.A.4
  • 13
    • 0017661095 scopus 로고
    • Isozyme patterns of branched-chain amino acid transaminase in human tissues and tumors
    • Goto M, Shinno H, Ichihara A. Isozyme patterns of branched-chain amino acid transaminase in human tissues and tumors. Gann 1977;68:663-7.
    • (1977) Gann , vol.68 , pp. 663-667
    • Goto, M.1    Shinno, H.2    Ichihara, A.3
  • 14
    • 0017325775 scopus 로고
    • Distribution of branched-chain α-ketoacid dehydrogenase in primate tissues
    • Khatra BS, Chawla RK, Sewell CW, Rudman D. Distribution of branched-chain α-ketoacid dehydrogenase in primate tissues, J Clin Invest 1977;59:558-64.
    • (1977) J Clin Invest , vol.59 , pp. 558-564
    • Khatra, B.S.1    Chawla, R.K.2    Sewell, C.W.3    Rudman, D.4
  • 15
    • 0019987837 scopus 로고
    • Degradation of branched-chain amino acids and their derived 2-oxo acids and fatty acids in human and rat heart and skeletal muscle
    • Wagenmakers AJ, Veerkamp JH. Degradation of branched-chain amino acids and their derived 2-oxo acids and fatty acids in human and rat heart and skeletal muscle. Biochem Med 1982;28:16-31.
    • (1982) Biochem Med , vol.28 , pp. 16-31
    • Wagenmakers, A.J.1    Veerkamp, J.H.2
  • 16
    • 16144362266 scopus 로고    scopus 로고
    • The valine catabolic pathway in human liver: Effect of cirrhosis on enzyme activities
    • Taniguchi K, Nonami T, Nakao A, et al. The valine catabolic pathway in human liver: effect of cirrhosis on enzyme activities. Hepatology 1996;24:1395-8.
    • (1996) Hepatology , vol.24 , pp. 1395-1398
    • Taniguchi, K.1    Nonami, T.2    Nakao, A.3
  • 17
    • 0028338785 scopus 로고
    • Dietary cholesterol and downregulation of cholesterol 7 α-hydroxylase and cholesterol absorption in African green monkeys
    • Rudel LL, Deckelman C, Wilson M, Scobey M, Anderson R. Dietary cholesterol and downregulation of cholesterol 7 α-hydroxylase and cholesterol absorption in African green monkeys, J Clin Invest 1994;93:2463-72.
    • (1994) J Clin Invest , vol.93 , pp. 2463-2472
    • Rudel, L.L.1    Deckelman, C.2    Wilson, M.3    Scobey, M.4    Anderson, R.5
  • 18
    • 0024207743 scopus 로고
    • Estimation of branched-chain α-ketoacid dehydrogenase activation in mammalian tissues
    • Block KP, Aftring RP, Buse MG, Harper AE. Estimation of branched-chain α-ketoacid dehydrogenase activation in mammalian tissues. Methods Enzymol 1988;166:201-13.
    • (1988) Methods Enzymol , vol.166 , pp. 201-213
    • Block, K.P.1    Aftring, R.P.2    Buse, M.G.3    Harper, A.E.4
  • 19
    • 0025057089 scopus 로고
    • Activation of branched-chain α-keto acid dehydrogenase complex by exercise: Effect of high-fat diet intake
    • Shimomura Y, Suzuki T, Saitoh S, Tasaki Y, Harris RA, Suzuki M. Activation of branched-chain α-keto acid dehydrogenase complex by exercise: effect of high-fat diet intake. J Appl Physiol 1990;68:161-5.
    • (1990) J Appl Physiol , vol.68 , pp. 161-165
    • Shimomura, Y.1    Suzuki, T.2    Saitoh, S.3    Tasaki, Y.4    Harris, R.A.5    Suzuki, M.6
  • 20
    • 0020494563 scopus 로고
    • Activation of the branched-chain α-keto acid dehydrogenase complex by a broad specific protein phosphatase
    • Harris RA, Paxton R, Parker RA. Activation of the branched-chain α-keto acid dehydrogenase complex by a broad specific protein phosphatase. Biochem Biophys Res Commun 1982;107:1497-503.
    • (1982) Biochem Biophys Res Commun , vol.107 , pp. 1497-1503
    • Harris, R.A.1    Paxton, R.2    Parker, R.A.3
  • 21
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 22
    • 0030901404 scopus 로고    scopus 로고
    • Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm)
    • Bledsoe RK, Dawson PA, Hutson SM. Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm). Biochim Biophys Acta 1997;1339:9-13.
    • (1997) Biochim Biophys Acta , vol.1339 , pp. 9-13
    • Bledsoe, R.K.1    Dawson, P.A.2    Hutson, S.M.3
  • 24
    • 0017083862 scopus 로고
    • Branched-chain amino acid oxidation by isolated rat tissue preparations
    • Shinnick FL, Harper AE. Branched-chain amino acid oxidation by isolated rat tissue preparations. Biochim Biophys Acta 1976;437:477-86.
    • (1976) Biochim Biophys Acta , vol.437 , pp. 477-486
    • Shinnick, F.L.1    Harper, A.E.2
  • 25
    • 0019813242 scopus 로고
    • Body and organ weights in relation to age and sex in Macaco, mulatta
    • Cupp CJ, Uemura E. Body and organ weights in relation to age and sex in Macaco, mulatta. J Med Primatol 1981;10:110-23.
    • (1981) J Med Primatol , vol.10 , pp. 110-123
    • Cupp, C.J.1    Uemura, E.2
  • 26
    • 0006507638 scopus 로고
    • Ober den gehalt normaler menschlicher organe an chlor, calcium, magnesium und eisen sowie an wasser, eiweiß und fett
    • in German
    • Magnus-Levy A. Ober den gehalt normaler menschlicher organe an chlor, calcium, magnesium und eisen sowie an wasser, eiweiß und fett. (Concerning the normal human organ content of chloride, calcium and iron as well as water, protein and fat.) Biochem Z 1910;24:363-80 (in German).
    • (1910) Biochem Z , vol.24 , pp. 363-380
    • Magnus-Levy, A.1
  • 27
    • 0022731676 scopus 로고
    • Mitochondrial targeting sequences may form amphiphilic helices
    • Von Heij G. Mitochondrial targeting sequences may form amphiphilic helices. EMBO J 1986;5:1335-42.
    • (1986) EMBO J , vol.5 , pp. 1335-1342
    • Von Heij, G.1
  • 28
    • 0028149769 scopus 로고
    • Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinase
    • Popov KM, Kedishvili NY, Zhao Y, Gudi R, Harris RA. Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinase. J Biol Chem 1994;269:29720-4.
    • (1994) J Biol Chem , vol.269 , pp. 29720-29724
    • Popov, K.M.1    Kedishvili, N.Y.2    Zhao, Y.3    Gudi, R.4    Harris, R.A.5
  • 30
    • 0018246928 scopus 로고
    • Regulation of leucine and α-ketoisocaproate metabolism in skeletal muscle
    • Hutson SM, Cree TC, Harper AE. Regulation of leucine and α-ketoisocaproate metabolism in skeletal muscle. J Biol Chem 1978;25:8126-33.
    • (1978) J Biol Chem , vol.25 , pp. 8126-8133
    • Hutson, S.M.1    Cree, T.C.2    Harper, A.E.3
  • 31
    • 0024956076 scopus 로고
    • Thoughts on the role of branched-chain α-keto acid dehydrogenase complex in nitrogen metabolism
    • Harper AE. Thoughts on the role of branched-chain α-keto acid dehydrogenase complex in nitrogen metabolism. Ann N Y Acad Sci 1989;573:267-73.
    • (1989) Ann N Y Acad Sci , vol.573 , pp. 267-273
    • Harper, A.E.1
  • 32
    • 0020678748 scopus 로고
    • Effects of ingested steak and infused leucine on forelimb metabolism in man and the fate of the carbon skeletons and ammo groups of branched-chain amino acids
    • Elia M, Livesey G. Effects of ingested steak and infused leucine on forelimb metabolism in man and the fate of the carbon skeletons and ammo groups of branched-chain amino acids. Clin Sci 1983;64:517-26.
    • (1983) Clin Sci , vol.64 , pp. 517-526
    • Elia, M.1    Livesey, G.2
  • 34
    • 0015186836 scopus 로고
    • Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
    • Oldendorf WH. Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am J Pysiol 1971;221:1629-39.
    • (1971) Am J Pysiol , vol.221 , pp. 1629-1639
    • Oldendorf, W.H.1
  • 35
    • 0023634699 scopus 로고
    • Kinetics of neutral amino acid transport across the blood-brain barrier
    • Smith QR, Momma S, Aoyagi M, Rapoport SI. Kinetics of neutral amino acid transport across the blood-brain barrier. J Neurochem 1987;49:1651-8.
    • (1987) J Neurochem , vol.49 , pp. 1651-1658
    • Smith, Q.R.1    Momma, S.2    Aoyagi, M.3    Rapoport, S.I.4
  • 37
    • 0028883117 scopus 로고
    • Dietary control and tissue specific expression of branched-chain α-ketoacid dehydrogenase kinase
    • Popov KM, Zhao Y, Shimomura Y, et al. Dietary control and tissue specific expression of branched-chain α-ketoacid dehydrogenase kinase. Arch Biochem Biophys 1995;316:148-54.
    • (1995) Arch Biochem Biophys , vol.316 , pp. 148-154
    • Popov, K.M.1    Zhao, Y.2    Shimomura, Y.3
  • 38
    • 0029775063 scopus 로고    scopus 로고
    • Mechanisms of activation of muscle branched-chain α-keto acid dehydrogenase during exercise in man
    • van Hall G, MacLean DA, Saltin B, Wagenmakers ATM. Mechanisms of activation of muscle branched-chain α-keto acid dehydrogenase during exercise in man. J Physiol 1996;494:899-905.
    • (1996) J Physiol , vol.494 , pp. 899-905
    • Van Hall, G.1    MacLean, D.A.2    Saltin, B.3    Atm, W.4
  • 39
    • 0025201970 scopus 로고
    • Effect of infused branched-chain amino acids on muscle and whole-body amino acid metabolism in man
    • Louard RJ, Barrett J, Gelfand RA. Effect of infused branched-chain amino acids on muscle and whole-body amino acid metabolism in man. Clin Sci 1990;79:457-66.
    • (1990) Clin Sci , vol.79 , pp. 457-466
    • Louard, R.J.1    Barrett, J.2    Gelfand, R.A.3
  • 40
    • 0028817993 scopus 로고
    • Deamination of amino acids as a source for ammonia production in human skeletal muscle during prolonged exercise
    • van Hall G, Saltin B, van der Vusse GJ, Söderlund K, Wagenmakers AJM. Deamination of amino acids as a source for ammonia production in human skeletal muscle during prolonged exercise. J Physiol 1995;489:251-61.
    • (1995) J Physiol , vol.489 , pp. 251-261
    • Van Hall, G.1    Saltin, B.2    Van der Vusse, G.J.3    Söderlund, K.4    Wagenmakers, A.J.M.5
  • 41
    • 0028873202 scopus 로고
    • Rat muscle branched-chain ketoacid dehydrogenase activity and mRNAs increase with extracellular acidemia
    • England BK, Greiber S, Mitch WE, et al. Rat muscle branched-chain ketoacid dehydrogenase activity and mRNAs increase with extracellular acidemia. Am J Physiol 1995;268:C1395-400.
    • (1995) Am J Physiol , vol.268
    • England, B.K.1    Greiber, S.2    Mitch, W.E.3
  • 42
    • 2642631417 scopus 로고
    • Effects of starvation and diabetes on leucine and valine metabolism in the perfused hindquarter
    • Hutson SM. Effects of starvation and diabetes on leucine and valine metabolism in the perfused hindquarter. Ann N Y Acad Sci 1989;18:239-44.
    • (1989) Ann N Y Acad Sci , vol.18 , pp. 239-244
    • Hutson, S.M.1
  • 43
    • 0026333405 scopus 로고
    • Effect of α-ketoacid dehydrogenase phosphorylation on branched-chain amino acid metabolism in muscle
    • Hood DA, Terjung RL. Effect of α-ketoacid dehydrogenase phosphorylation on branched-chain amino acid metabolism in muscle. Am J Physiol 1991;261:E628-34.
    • (1991) Am J Physiol , vol.261
    • Hood, D.A.1    Terjung, R.L.2
  • 44
    • 0025309167 scopus 로고
    • Metabolism of branched-chain amino acids and ammonia during exercise: Clues from McArdle's disease
    • Wagenmakers AJM, Coakley JH, Edwards RHT. Metabolism of branched-chain amino acids and ammonia during exercise: clues from McArdle's disease. Int J Sports Med 1990;11:S101-13.
    • (1990) Int J Sports Med , vol.11
    • Wagenmakers, A.J.M.1    Coakley, J.H.2    Edwards, R.H.T.3
  • 45
    • 0030015804 scopus 로고    scopus 로고
    • Stimulation of muscle ammonia production during exercise following branched-chain amino acid supplementation in humans
    • MacLean DA, Graham TE, Saltin B. Stimulation of muscle ammonia production during exercise following branched-chain amino acid supplementation in humans. J Physiol 1996;493:909-22.
    • (1996) J Physiol , vol.493 , pp. 909-922
    • MacLean, D.A.1    Graham, T.E.2    Saltin, B.3
  • 46
    • 2642661146 scopus 로고
    • Relationship of branched-chain amino acids (BCAA) to skeletal muscle gluconeogenic amino acids
    • Hutson SM. Relationship of branched-chain amino acids (BCAA) to skeletal muscle gluconeogenic amino acids. Ann N Y Acad Sci 1989;18:245-50.
    • (1989) Ann N Y Acad Sci , vol.18 , pp. 245-250
    • Hutson, S.M.1
  • 47
    • 0026494762 scopus 로고
    • Amino acid metabolism, muscular fatigue and muscle wasting
    • Wagenmakers AJM. Amino acid metabolism, muscular fatigue and muscle wasting. Int J Sports Med 1992;13:S110-3.
    • (1992) Int J Sports Med , vol.13
    • Wagenmakers, A.J.M.1
  • 48
    • 0018843753 scopus 로고
    • Early changes of muscle mitochondria in Duchenne dystrophy
    • Scholte HR, Busch FM. Early changes of muscle mitochondria in Duchenne dystrophy. J Neurol Sci 1980;45:217-34.
    • (1980) J Neurol Sci , vol.45 , pp. 217-234
    • Scholte, H.R.1    Busch, F.M.2
  • 49
    • 0022506793 scopus 로고
    • Glutamate dehydrogenase in olivopontocerebellar atrophies: Leukocytes, fibroblasts, and muscle mitochondria
    • Finocchiaro G, Taroni F, Di Donato S. Glutamate dehydrogenase in olivopontocerebellar atrophies: leukocytes, fibroblasts, and muscle mitochondria. Neurology 1986;36:550-3.
    • (1986) Neurology , vol.36 , pp. 550-553
    • Finocchiaro, G.1    Taroni, F.2    Di Donato, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.