Progressive structuring of a branched antimicrobial peptide on the path to the inner membrane target

Journal of Biological Chemistry

Volumn 287, Issue 32, 2012, Pages 26606-26617

  Bai, Yang ^a,b   Liu, Shouping ^a   Li, Jianguo ^c   Lakshminarayanan, Rajamani ^a   Sarawathi, Padmanabhan ^a   Tang, Charles ^d   Ho, Duncun ^b   Verma, Chandra ^b,c,e   Beuerman, Roger W ^a,e   Pervushin, Konstantin ^b  

^a SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c BIOINFORMATICS INSTITUTE   (Singapore)

^d SINGAPORE GENERAL HOSPITAL   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIPHILICS; ANTIMICROBIAL PEPTIDE; ANTIMICROBIAL PROPERTY; BACTERIAL LYSIS; BRANCH POINTS; CONDENSED STATE; ENHANCED MOBILITY; ENVIRONMENT-SENSITIVE; FLUORESCENT PROBES; GRAM-NEGATIVE PATHOGENS; HIGH RESOLUTION; INNER MEMBRANES; LIPOPOLYSACCHARIDES; MEMBRANE LIPIDS; MEMBRANE PERMEABILITY; MEMBRANE-WATER INTERFACE; MOLECULAR DYNAMICS SIMULATIONS; OUTER MEMBRANE; PEPTIDE DESIGN; SPATIAL STRUCTURE; STRUCTURAL COMPACTION; STRUCTURAL MOTIFS; STRUCTURAL TRANSITIONS; STRUCTURE ACTIVITY RELATIONSHIPS;

BIOCOMPATIBILITY; ELECTRON MICROSCOPY; LIPIDS; MOLECULAR DYNAMICS; PEPTIDES; POLYPEPTIDES;

MEMBRANES;

ANTIMICROBIAL PEPTIDE B2088; BACTERIUM LIPOPOLYSACCHARIDE; FLUORESCENT DYE; LIPID; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; WATER;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INNER MEMBRANE; BACTERIAL MEMBRANE; BACTERIAL OUTER MEMBRANE; BACTERIOLYSIS; CULTURE MEDIUM; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG TARGETING; DRUG TRANSPORT; ELECTRON MICROSCOPY; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHYSICAL PHASE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; CELL MEMBRANE; FLUORESCENT DYES; HEMOLYSIS; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN CONFORMATION;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 84864556578     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.363259     Document Type: Article

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