A novel tetrabranched antimicrobial peptide that neutralizes bacterial lipopolysaccharide and prevents septic shock in vivo

FASEB Journal

Volumn 24, Issue 4, 2010, Pages 1015-1022

  Pini, Alessandro ^a   Falciani, Chiara ^a   Mantengoli, Elisabetta ^a   Bindi, Stefano ^a   Brunetti, Jlenia ^a   Iozzi, Sara ^a   Maria Rossolini, Gian ^a   Bracci, Luisa ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

Antibacterial; Cystic fibrosis; Dendrimers; Gram negative bacteria; LPS

Indexed keywords

LIPOPOLYSACCHARIDE; LYSYLLYSYLISOLEUCYLARGINYLVALYLARGINYLLEUCYLSERYLALANINE; POLYMYXIN B; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; PEPTIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; IN VIVO STUDY; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; REPEATED DRUG DOSE; SEPTIC SHOCK; SINGLE DRUG DOSE; ANIMAL; ANTIBIOTIC RESISTANCE; BAGG ALBINO MOUSE; DRUG ANTAGONISM; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; MACROPHAGE; MACROPHAGE ACTIVATION; METABOLISM; MULTIDRUG RESISTANCE;

ANIMALS; ANTI-INFECTIVE AGENTS; DRUG RESISTANCE, BACTERIAL; DRUG RESISTANCE, MULTIPLE; GRAM-NEGATIVE BACTERIA; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED BALB C; PEPTIDES; SHOCK, SEPTIC; TUMOR NECROSIS FACTOR-ALPHA;

ACINETOBACTER BAUMANNII; ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

EID: 77951626660     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-145474     Document Type: Article

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